Mechanisms of Deficient Innate Immune Responses in Asthma

哮喘先天免疫反应缺陷的机制

• 批准号: G0601236/1
• 负责人: Sebastian Johnston
• 金额: $ 155.42万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601236%2F1
• 关键词: Mechanisms; Deficient; Innate; Immune; Responses

Asthma is the most common chronic respiratory disease in the UK. The majority of healthcare costs are related to acute attacks. Acute attacks are also dreaded by asthma sufferers, as they lead to severe breathlessness, hospitalisation or death. Current therapies are not good at either treatment or prevention of acute attacks. New approaches to therapy are therefore urgently needed. Asthma attacks are caused by common cold viruses, which ?go to the chest?, some are also made worse by chronic bacterial colonisation which can be ?reactivated? during acute attacks. We have discovered asthmatics have weak immune responses to viral and bacterial infections, accounting for their increased susceptibility to these infections. We plan to carry out detailed studies of anti-viral and anti-bacterial immunity in lung cells from adults with asthma, to identify the molecules deficient in switching on immune responses in the lung during these attacks. We will also study different forms of asthma to see how widespread these deficiencies are, and will study children through from birth to 6 years of age, to see when these deficiencies develop. Finally we will see if the deficiencies are detected in blood tests so they can be more easily identified.By identifying the molecules that are deficient during these attacks, we should be able to identify targets for the development of new therapies for both prevention and treatment of acute attack of asthma. So doing would greatly reduce distress suffered by asthma patients, as well as reducing mortality and health care costs.

哮喘是英国最常见的慢性呼吸道疾病。大部分医疗费用与急性发作有关。哮喘患者也害怕急性发作，因为它们会导致严重的呼吸困难，住院治疗或死亡。目前的疗法既不擅长治疗也不擅长预防急性发作。因此，迫切需要新的治疗方法。哮喘发作是由普通感冒病毒引起的，哪种？去胸部？有些人还恶化的慢性细菌定植，这可能是？重新激活？急性发作时。我们发现哮喘患者对病毒和细菌感染的免疫反应较弱，这是他们对这些感染易感性增加的原因。我们计划在成人哮喘患者的肺细胞中进行抗病毒和抗细菌免疫的详细研究，以确定在这些攻击期间肺中启动免疫反应的分子缺陷。我们还将研究不同形式的哮喘，看看这些缺陷有多普遍，并将研究从出生到6岁的儿童，看看这些缺陷何时发展。最后，我们将看看是否在血液测试中检测到这些缺陷，以便更容易地识别它们。通过识别在这些发作期间缺乏的分子，我们应该能够确定开发新疗法的目标，用于预防和治疗哮喘急性发作。这样做将大大减少哮喘患者所遭受的痛苦，并降低死亡率和医疗保健费用。