Clinical and Educational Core

临床和教育核心

• 批准号: 7797222
• 负责人: ROBERT T MALISON
• 金额: $ 18.8万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797222
• 关键词: Behavioral; Clinical; Clinical Research; Cocaine; Corpus striatum structure; Diagnostic; Drug Addiction; Education; Eligibility Determination; Goals; Human; Individual; Methylphenidate; Mission; Neurobiology; Neurocognitive; Participant; Pharmaceutical Preparations; Research; Screening procedure; Self Administration; Training; Translational Research; career development; clinical care; meetings; programs; psychopharmacologic; response

The Clinical and Educational Core (CEC; Core 2) will assume Center-wide responsibility for four major components of the ExCITRA (P20), including: 1) the recruitment, screening, diagnostic assessment, and clinical care of all human research participants; 2) the comprehensive neurocognitive assessment of all subjects successfully meeting eligibility criteria; 3) the concurrent psychopharmacologic characterization of individuals' subjective, behavioral, and neurocognitive responses to stimulant self-administration (cocaine in cocaine dependent subjects) and/or administration (methylphenidate in cocaine dependent and healthy control subjects); and, 4) the coordination of research career development of affiliated trainees in the interdisciplinary and translational neurobiology of drug addicfion.

临床和教育核心（CEC;核心2）将承担整个中心范围内ExCITRA（P20）四个主要组成部分的责任，包括：1）所有人类研究参与者的招募、筛选、诊断评估和临床护理; 2）成功满足合格标准的所有受试者的综合神经认知评估; 3）同时进行的精神药理学表征 个体对兴奋剂自我给药（可卡因依赖受试者中的可卡因）和/或给药（可卡因依赖和健康对照受试者中的哌醋甲酯）的主观、行为和神经认知反应;以及，4）协调附属受训人员在研究中的职业发展。 药物成瘾跨学科和转化神经生物学。