Patient-Oriented Research and Mentoring in the Translational Neurobiology/Genetic

描述（由申请人提供）：面向患者研究的职业中期研究者奖（K24）此K24申请寻求支持，对于候选人作为独立的，面向患者的研究人员和导师的持续职业发展至关重要。候选人在兴奋剂成瘾的临床神经生物学方面获得了相当多的专业知识，采用了趋同的方法（神经影像学、精神药理学、药物自我给药，以及最近的遗传学）。他表现出相当高的生产力，这证明了同行评审的出版物（无论是作为主要作者还是资深作者）和校外研究支持（6个r01, 1个R03, 2个研究培训资助，2个中心资助部分，一个主要中心的科学联合主任和6个基金会资助奖项）。然而，候选人的K02到期导致他不得不承担与本研究无关的主要（bbb50 %）临床和行政责任。这发生在一个关键时刻，因为这个新的领域（遗传学）需要高度专业化的培训，并且受训人员越来越依赖于这方面的专业知识。因此，K24奖对于维持候选人以患者为导向的研究和与研究相关的指导活动至关重要。此外，该奖项将使候选人沉浸在一个快速变化的领域，从而促进他在物质依赖遗传学方面掌握新的独立研究技能。该奖项的理由是提供了一个全面的5年职业发展计划，其中1)允许候选人提高复杂性状的遗传学/药物遗传学技能，2)使候选人能够继续指导临床研究的初级研究人员。强化培训由校内课程、校外教学、个性化指导、互动式专题讨论会和与研究相关的组织会议等综合课程提供。详细介绍了两项具有代表性的研究-包括1)孤立人群（活跃）的药物依赖研究和2)可卡因，双硫醚和多巴胺β -羟化酶（DBH）基因遗传变异（C-1021T）的药理学研究。

DESCRIPTION (provided by applicant): MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEARCH (K24) This K24 application seeks support that is essential for the candidate's continued career development as an independent, patient-oriented researcher and mentor. The candidate has attained considerable expertise in the clinical neurobiology of stimulant addiction, employing convergent methodologies (neuroimaging, psychopharmacology, drug self-administration, and most recently, genetics). He has demonstrated considerable productivity as evidenced by peer-reviewed publications (both as principal and senior author) and extramural research support (6 R01s, 1 R03, 2 research training grants, 2 center grant sections, scientific co-directorship of a major center, and 6 foundation grant awards). However, expiration of the candidate's K02 has resulted in him having to assume major (>50%) clinical and administrative responsibilities unrelated to this research. This occurs at a critical time, as this new area (genetics) requires highly specialized training and increasing reliance of trainees on this expertise. Thus, the K24 award is vital for sustaining the candidate's patient-oriented research and research-related mentoring activates. Moreover, the award will enable the candidate's immersion in an area of rapid change, thereby facilitating his mastery of newly independent research skills in substance dependence genetics. Justification for the award is provided by a comprehensive 5-year career development plan which 1) allows the candidate to enhance skills in the genetics / pharmacogenetics of complex traits, and 2) enables the candidate to continue his mentoring of beginning investigators in clinical research. Intensive training is provided by an integrated curriculum of intramural coursework, extramural didactics, individualized preceptorships, interactive symposia, and research-related organizational meetings. Two representative research studies are presented in detail - including 1) a study of drug dependence in an isolated population (active) and 2) a pharmacogenetic study of cocaine, disulfiram and genetic variation (C-1021T) in the gene for dopamine beta-hydroxylase (DBH).