Patient-Oriented Research and Mentoring in the Translational Neurobiology/Genetic

描述（由申请人提供）：Midcareer professionator AWARD IN PATIENT-ORIENTED RESEARCH（K24）此K24申请寻求对候选人作为独立的，以患者为导向的研究人员和导师的持续职业发展至关重要的支持。候选人在兴奋剂成瘾的临床神经生物学方面获得了相当多的专业知识，采用收敛方法（神经影像学，精神药理学，药物自我管理，最近，遗传学）。他已经表现出相当高的生产力，这一点可以通过同行评审的出版物（作为主要和高级作者）和校外研究支持（6 R 01 s，1 R 03，2研究培训赠款，2中心补助金部分，一个主要中心的科学共同董事，和6个基金会补助金）来证明。然而，候选人的K 02到期导致其不得不承担与本研究无关的主要（>50%）临床和管理职责。这是在一个关键时刻发生的，因为这个新领域（遗传学）需要高度专业化的培训，而且受训者越来越依赖这一专门知识。因此，K24奖对于维持候选人以患者为导向的研究和与研究相关的指导活动至关重要。此外，该奖项将使候选人沉浸在一个快速变化的领域，从而促进他在物质依赖遗传学的新的独立研究技能的掌握。该奖项的理由是由一个全面的5年职业发展计划提供的，该计划1）允许候选人提高复杂性状的遗传学/药物遗传学技能，2）使候选人能够继续指导临床研究中的初级研究者。强化培训是由校内课程，校外教学法，个性化的preceptorships，互动研讨会和研究相关的组织会议的综合课程。详细介绍了两项具有代表性的研究-包括1）一项在隔离人群中进行的药物依赖性研究（活动）和2）一项可卡因、双硫仑和多巴胺β-羟化酶（DBH）基因遗传变异（C-1021 T）的药物遗传学研究。

DESCRIPTION (provided by applicant): MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEARCH (K24) This K24 application seeks support that is essential for the candidate's continued career development as an independent, patient-oriented researcher and mentor. The candidate has attained considerable expertise in the clinical neurobiology of stimulant addiction, employing convergent methodologies (neuroimaging, psychopharmacology, drug self-administration, and most recently, genetics). He has demonstrated considerable productivity as evidenced by peer-reviewed publications (both as principal and senior author) and extramural research support (6 R01s, 1 R03, 2 research training grants, 2 center grant sections, scientific co-directorship of a major center, and 6 foundation grant awards). However, expiration of the candidate's K02 has resulted in him having to assume major (>50%) clinical and administrative responsibilities unrelated to this research. This occurs at a critical time, as this new area (genetics) requires highly specialized training and increasing reliance of trainees on this expertise. Thus, the K24 award is vital for sustaining the candidate's patient-oriented research and research-related mentoring activates. Moreover, the award will enable the candidate's immersion in an area of rapid change, thereby facilitating his mastery of newly independent research skills in substance dependence genetics. Justification for the award is provided by a comprehensive 5-year career development plan which 1) allows the candidate to enhance skills in the genetics / pharmacogenetics of complex traits, and 2) enables the candidate to continue his mentoring of beginning investigators in clinical research. Intensive training is provided by an integrated curriculum of intramural coursework, extramural didactics, individualized preceptorships, interactive symposia, and research-related organizational meetings. Two representative research studies are presented in detail - including 1) a study of drug dependence in an isolated population (active) and 2) a pharmacogenetic study of cocaine, disulfiram and genetic variation (C-1021T) in the gene for dopamine beta-hydroxylase (DBH).