Administrative Core

这个行政核心(核心A)将有两个主要功能。首先，它将提供行政支持 并为这个项目的调查人员提供智力上的丰富。由于该方案包括5个 来自两个机构(加州大学圣地亚哥分校和伯纳姆研究所)的高级调查人员 系：儿科、内科、神经科学、药理学、外科(加州大学圣迭戈分校医学院)、 生物医学工程(UCSD)、计算机科学和伯纳姆研究所。正因为如此 而且该计划的多学科性质，一个中央行政核心是必不可少的。核心将起作用 与两大院校的行政部门以及行政人员、业务管理人员、 以及参与其中的各个部门的科学家。行政核心将协助个人调查员 预算以及协调差旅、采购、会议和研讨会。的第二个功能 管理核心将是提供和鼓励 计划项目、大学内部的教职员工(不是此计划项目的成员)和外部 顾问。核心中心将通过两种方式实现这些目标：a)我们将每月举办两个小时的研讨会 为本计划中的所有调查人员。研究进展将由该计划的一个 每次研讨会期间都有调查人员参加。这将平均每年约10-12次研讨会，每年约2-3次 项目/年。我们还将让B和C核的董事提出新的数据分析技术， 系统生物学重建分子研究、代谢物通量分析等。B)计划 项目计划每年有外部专家作为顾问访问，至少有一个项目组。这个 顾问的作用将是直接与东道主合作，就他们的进展提供意见，提出建议 可能为个别项目和潜在的整个计划指明新的方向。此外，我们 还建议举办中期全天研讨会，在此期间我们邀请正在进行工作的顾问 对每个项目的研究进行了一些方面的研究。在这些工作坊期间，每一位专业人员都介绍了他们的 过去两年的进展，并请外部专家批判性地评估 每个项目。

This Administrative Core (Core A) will have two major functions. First, it will provide administrative support and intellectual enrichment for the investigators in this program. Due to the fact that the Program includes 5 senior investigators from two institutions (UCSD and the Burnham Institute) belonging to several Departments: Pediatrics, Medicine, Neuroscience, Pharmacology, Surgery (School of Medicine at UCSD), Biomedical Engineering (UCSD), Computer Science and the Burnham Research Institute. Because of this and the multi-disciplinary nature of the Program, a central administrative core is essential. The Core will work closely with the Administration of the two major institutions, as well as administrators, business managers, and scientists in each Department involved. The Administrative Core will assist individual investigators in budgeting as well as coordinate travel, purchasing, meetings and seminars. The second function of the Administrative Core will be to provide and encourage intellectual collaboration between members of the Program Project, faculty within the University (who are not members of this Program Project), and outside consultants. The Core will achieve these objectives in two ways: A) We will have a monthly two-hour seminar for all investigators in this Program. Research progress will be presented by one of the Program's investigators during each seminar. This will average about 10-12 seminars per year and about 2-3 per Project/year. We will also have the Directors of Cores B and C present new data analytical techniques, systems biology re-construction of molecular studies, flux analysis of metabolites etc.... B) The Program Project plans to have outside experts' visit each year as consultants, at least one of the Project groups. The role of the consultant will be to work directly with his/her host, to advise regarding their progress, to suggest possible new directions for both the individual Projects and potentially the overall Program. In addition, we propose also to have mid-term whole day symposium during which we invite consultants whose work is on some aspects of the research of each Project. During these workshops, each of the Pis presents their progress over the preceding 2 years and the outside experts are asked to critically evaluate the progress of each project.