Histopathology

组织病理学核心将为所有3个项目提供完整的支持。这一核心将集中 PPG所有项目的病理学资源。这将节省成本，提高质量 控制和项目结果之间的最大可比性。 核心的主要功能包括：1)在实验设计的免疫组织学方面的专家建议 优化结果；2)均匀的组织处理；3)组织切片(冰冻切片和石蜡包埋 切片；4)组织切片和免疫组织化学染色；5)病理 裂隙切片的解释；6)用高质量的数字显微镜进行病理记录 摄影；7)手稿图形的准备；8)每一张染色幻灯片的储存和检索 这些项目。 此外，该中心将负责所有抗体的订购、质量保证和控制研究 以及病理学方法中使用的试剂。新试剂将被开发和评估为 应3个项目调查人员的要求。

The Histopathology Core will provide integral support for all 3 projects. This core will centralize the pathology resources for all of the projects of the PPG. This will result in cost savings, increased quality control and maximal comparability between the results of the projects. Key funcfions of the Core include: 1) expert advise in immunohistological aspects of experimental design to optimize results; 2) uniform tissue processing; 3) tissue secfioning (frozen sections and paraffin-embedded sections); 4) histochemical and immunohistochemical staining of tissue secfions; 5) pathological interpretation of fissue sections; 6) documentafion of the pathology by high quality digital microscopic photography; 7) preparation of figures for manuscripts; 8) storage and retrieval of stained slides for each of the projects. In addifion, this Core will be responsible for ordering, quality assurance and control studies of all anfibodies and reagents for use in the pathology methods. New reagents will be developed and evealuated as requested by investigators in the 3 projects.