The Spatiotemporal Vibratory Characteristics Of Pathological Vocal Folds

病理性声带的时空振动特征

• 批准号: 7826744
• 负责人: Jack J Jiang
• 金额: $ 29.84万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7826744
• 关键词: Achievement; Acoustics; Acute Laryngitis; Aftercare; Age; Behavior Disorders; Biomechanics; Carcinoma; Characteristics; Cicatrix; Clinical; Clinical Research; Complex; Data; Databases; Development; Diagnosis; Disease; Functional disorder; Gender; Goals; Heart; Human; Image; Individual; Laryngeal Diseases; Laryngeal Paralysis; Larynx; Lasers; Lead; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modeling; Nodule; Pathology; Patients; Pattern; Physiological; Physiology; Polyps; Principal Investigator; Process; Production; Property; Receiver Operating Characteristics; Request for Applications; Research; Sensitivity and Specificity; Series; Speed; System; Techniques; Testing; Training; Visual Cortex; Voice; Voice Disorders; base; clinical application; human subject; image processing; improved; planetary Atmosphere; pressure; programs; spatiotemporal; tool; treatment effect; vibration; vocal cord

DESCRIPTION (provided by applicant): In the last decade, the temporal properties of voice production have been explored extensively in laryngeal physiology studies. However, these studies display a lack of information concerning the spatial aspect of disordered voice production. Disordered voice production involves both temporal and spatial properties. Spatiotemporal analysis on a bench model demonstrates the value of understanding physiological disorders in laryngeal systems. The overall aim of this study is to develop feasible clinical applications of high-speed measurements and spatiotemporal analysis methods to quantify the vibratory properties of vocal folds of patients with laryngeal diseases. Five projects will be proposed in this proposal. The first project will optimize a series of spatiotemporal analysis methods for clinical high-speed imaging data. We propose measuring the mucosal wave with spatiotemporal perturbation analysis, spatiotemporal correlation analysis, and eigenmode analysis. The second project will focus on measuring the biomechanical parameters of the vocal folds using high-speed imaging data of human subjects. A synchronization-based parameter estimation method is proposed to determine the biomechanical parameters of human vocal folds. The third project will apply high-speed imaging measurement and analysis methods to establish norms by documenting the vibratory characteristics of vocal function in normal subjects. The fourth project will explore the high-speed imaging measurement and analysis of laryngeal pathologies, including vocal nodules and polyps, laryngeal paralysis, vocal fold scarring, vocal fold cancer, and acute laryngitis. The sensitivity and specificity of spatiotemporal analysis parameters in distinguishing healthy voices from disordered voices will be investigated. The fifth project will employ the developed analysis of high-speed imaging to assess the treatment effects of vocal nodules and polyps, laryngeal paralysis, vocal fold scarring, vocal fold cancer, and acute laryngitis.

描述（由申请人提供）：在过去的十年中，在喉种生理学研究中广泛探讨了语音生产的时间特性。但是，这些研究表明缺乏有关语音生产无序空间方面的信息。语音产生无序涉及时间和空间特性。基准模型上的时空分析证明了理解喉系统生理障碍的价值。这项研究的总体目的是开发高速测量和时空分析方法的可行临床应用，以量化喉部疾病患者声带的振动特性。该提案将提出五个项目。第一个项目将优化用于临床高速成像数据的一系列时空分析方法。我们提出了通过时空扰动分析，时空相关分析和本本特莫德分析来测量粘膜波。第二个项目将着重于使用人类受试者的高速成像数据来测量声带的生物力学参数。提出了一种基于同步的参数估计方法来确定人声折叠的生物力学参数。第三个项目将采用高速成像测量和分析方法来通过记录正常受试者声乐功能的振动特征来确定规范。第四个项目将探索喉病理学的高速成像测量和分析，包括声音结节和息肉，喉部瘫痪，人声折叠疤痕，声折叠癌，声带癌和急性喉炎。将研究在区分健康声音和无序声音的时空分析参数的敏感性和特异性。第五个项目将采用对高速成像的开发分析来评估声带和息肉的治疗效果，喉部瘫痪，声带疤痕，声折叠癌和急性喉炎。