The interaction between vocal fold hydration and vibratory biomechanics

声带水合与振动生物力学之间的相互作用

• 批准号: 10407530
• 负责人: Jack J Jiang
• 金额: $ 35.03万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407530
• 关键词: Acoustics; Affect; Anatomy; Animal Model; Benign; Biomechanics; Blood capillaries; Blood flow; Canis familiaris; Capillary Permeability; Clinical; Clinical Management; Computer Models; Cyst; Dehydration; Drug or chemical Tissue Distribution; Dysphonia; Edema; Elements; Ensure; Equilibrium; Etiology; Evaluation; Fluid Balance; Frequencies; Goals; Homeostasis; Hydration status; Inflammation; Inflammatory Response; Intention; Intercellular Fluid; Knowledge; Laryngoscopes; Larynx; Laser-Doppler Flowmetry; Lead; Lesion; Link; Liquid substance; Maintenance; Measurement; Measures; Mechanics; Methods; Modeling; Movement; Nodule; Optical Coherence Tomography; Oryctolagus cuniculus; Pathologic; Pathology; Patients; Persons; Phonation; Physiological; Polyps; Property; Relaxation; Reporting; Research; Role; Severities; Solid; Speed; Stress; Study Subject; Surface; Technology; Tissues; Trauma; Validation; Voice; Voice Disorders; Voice Quality; Water; accurate diagnostics; base; capillary bed; clinical application; clinically significant; dielectric property; external ear auricle; in vivo; in vivo Model; interest; mechanical properties; new technology; novel; pressure; response; social; socioeconomics; tissue stress; tool; translation to humans; trend; ultrasound; vibration; vocal cord

Project Summary/Abstract Voice disorders affect millions of people worldwide. Patients have reported many negative social econmic impacts of dysphonia. Proper fluid homeostasis is critical to normal vocal fold function. Maintenance of normal fluid levels in vocal fold tissue ensures normal biomechanical and vibratory parameters. Potential disturbances to this homeostasis include overuse, misuse, systemic or surface dehydration, trauma, and inflammation. The results of these disturbances can lead to changes in stress distribution, mechanical damage, and inflammation. Further damage to the tissue might result in the formation of edema or a benign lesion. The overall goal of this proposal is to evaluate the contributions of vocal fold fluid homeostasis, tissue properties, and vibratory biomechanics to tissue damage and ultimately edema. The results will explain changes in vibration mechanics over extended periods of phonation. Methods of quantifying fluid content in excised and in vivo models developed in this proposal will provide necessary information on fluid content and further our knowledge and understanding of the role of fluid in vocal fold vibration. Knowledge gained from this research is essential for a more complete understanding of clinical management of voice disorders. The approach to this research will involve three specific aims. The first aim will focus on methods of quantifying fluid content and tissue properties. We will employ four technologies novel to laryngology: (1) tissue dielectric properties (TDP), a measure of tissue water content; (2) Optical Coherence Tomography (OCT) as a method to quantify fluid volume in tissues; (3) laser Doppler flowmetry, a measure of blood flow through a tissue; and (4) acoustoelastography, a measure of the acoustic properties of the tissue that is linearly related to strain and nonlinearly related to tissue stress. The results of these methods will be useful for establishing standards in interstitial fluid levels and tissue properties. The second aim will focus on evaluating the effects of vibration on fluid content and dynamics in the vocal folds. First, finite element modeling will be used to study the effects of vibration on fluid content and dynamics while varying elongation, subglottal pressure, capillary permeability and stiffness. Physiological validation of the model trends will be carried out on excised animal models. Finally, an animal model of inflammation due to prolonged vibration will be used to observe how edema might occur in vocal overuse. The third aim will focus on the effects of fluid content on vocal fold vibration. We will determine hydration levels at which the vocal folds are pathologically changed. In other words, when there is a significant change to phonation parameters such as phonation threshold pressure. Excised models will be used in this aim to study the biomechanical effects of dehydration and overhydration. In addition, acoustoelastography will be employed to study the change in stress distribution of the tissue with changes in fluid content.

项目概要/摘要 声音障碍影响着全世界数百万人。患者报告了许多负面的社会 发声困难的经济影响。适当的液体稳态对于正常声带功能至关重要。维护 声带组织中正常的液体水平可确保正常的生物力学和振动参数。潜在的 这种体内平衡的紊乱包括过度使用、误用、全身或表面脱水、创伤和 炎。这些干扰的结果可能导致应力分布的变化、机械损伤、 和炎症。对组织的进一步损伤可能导致水肿或良性病变的形成。 该提案的总体目标是评估声带液体稳态的贡献， 组织特性和振动生物力学对组织损伤并最终导致水肿。结果将 解释长时间发声期间振动力学的变化。液体定量方法 本提案中开发的切除模型和体内模型的内容将提供有关液体的必要信息 内容并进一步加深我们对流体在声带振动中的作用的认识和理解。知识 从这项研究中获得的成果对于更全面地了解声音的临床管理至关重要 失调。 这项研究的方法将涉及三个具体目标。第一个目标将侧重于方法 量化液体含量和组织特性。我们将采用四种喉科新颖技术：（1）组织 介电性能（TDP），组织含水量的衡量标准； (2) 光学相干断层扫描 (OCT) 量化组织中液体体积的方法； (3) 激光多普勒血流计，测量流经血管的血流量 组织; (4) 声弹性成像，一种与线性相关的组织声学特性的测量 应变与组织应力非线性相关。这些方法的结果将有助于建立 间质液水平和组织特性的标准。第二个目标将侧重于评估效果 振动对声带中液体含量和动态的影响。首先，将使用有限元建模来研究 振动对液体含量和动力学的影响，同时改变伸长率、声门下压力、毛细血管 渗透性和刚度。模型趋势的生理学验证将在切除的动物上进行 模型。最后，将使用长期振动引起的炎症动物模型来观察如何 声音过度使用可能会出现水肿。第三个目标将重点关注液体含量对声带的影响 振动。我们将确定声带发生病理变化时的水合水平。在其他方面 换句话说，当发声参数（例如发声阈值压力）发生显着变化时。 切除的模型将用于研究脱水和过度水合的生物力学效应。在 此外，声弹性成像技术将用于研究组织应力分布的变化 液体含量的变化。

项目成果

Study of spatiotemporal liquid dynamics in a vibrating vocal fold by using a self-oscillating poroelastic model.

使用自振荡多孔弹性模型研究振动声带中的时空液体动力学。

• DOI: 10.1121/10.0002163
• 发表时间: 2020
• 期刊: The Journal of the Acoustical Society of America
• 作者: Scholp,Austin;Jeddeloh,Caroline;Tao,Chao;Liu,Xiaojun;Dailey,SethH;Jiang,JackJ
• 通讯作者: Jiang,JackJ