The interaction between vocal fold hydration and vibratory biomechanics

声带水合与振动生物力学之间的相互作用

• 批准号: 10407530
• 负责人: Jack J Jiang
• 金额: $ 35.03万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407530
• 关键词: Acoustics; Affect; Anatomy; Animal Model; Benign; Biomechanics; Blood capillaries; Blood flow; Canis familiaris; Capillary Permeability; Clinical; Clinical Management; Computer Models; Cyst; Dehydration; Drug or chemical Tissue Distribution; Dysphonia; Edema; Elements; Ensure; Equilibrium; Etiology; Evaluation; Fluid Balance; Frequencies; Goals; Homeostasis; Hydration status; Inflammation; Inflammatory Response; Intention; Intercellular Fluid; Knowledge; Laryngoscopes; Larynx; Laser-Doppler Flowmetry; Lead; Lesion; Link; Liquid substance; Maintenance; Measurement; Measures; Mechanics; Methods; Modeling; Movement; Nodule; Optical Coherence Tomography; Oryctolagus cuniculus; Pathologic; Pathology; Patients; Persons; Phonation; Physiological; Polyps; Property; Relaxation; Reporting; Research; Role; Severities; Solid; Speed; Stress; Study Subject; Surface; Technology; Tissues; Trauma; Validation; Voice; Voice Disorders; Voice Quality; Water; accurate diagnostics; base; capillary bed; clinical application; clinically significant; dielectric property; external ear auricle; in vivo; in vivo Model; interest; mechanical properties; new technology; novel; pressure; response; social; socioeconomics; tissue stress; tool; translation to humans; trend; ultrasound; vibration; vocal cord

Project Summary/Abstract Voice disorders affect millions of people worldwide. Patients have reported many negative social econmic impacts of dysphonia. Proper fluid homeostasis is critical to normal vocal fold function. Maintenance of normal fluid levels in vocal fold tissue ensures normal biomechanical and vibratory parameters. Potential disturbances to this homeostasis include overuse, misuse, systemic or surface dehydration, trauma, and inflammation. The results of these disturbances can lead to changes in stress distribution, mechanical damage, and inflammation. Further damage to the tissue might result in the formation of edema or a benign lesion. The overall goal of this proposal is to evaluate the contributions of vocal fold fluid homeostasis, tissue properties, and vibratory biomechanics to tissue damage and ultimately edema. The results will explain changes in vibration mechanics over extended periods of phonation. Methods of quantifying fluid content in excised and in vivo models developed in this proposal will provide necessary information on fluid content and further our knowledge and understanding of the role of fluid in vocal fold vibration. Knowledge gained from this research is essential for a more complete understanding of clinical management of voice disorders. The approach to this research will involve three specific aims. The first aim will focus on methods of quantifying fluid content and tissue properties. We will employ four technologies novel to laryngology: (1) tissue dielectric properties (TDP), a measure of tissue water content; (2) Optical Coherence Tomography (OCT) as a method to quantify fluid volume in tissues; (3) laser Doppler flowmetry, a measure of blood flow through a tissue; and (4) acoustoelastography, a measure of the acoustic properties of the tissue that is linearly related to strain and nonlinearly related to tissue stress. The results of these methods will be useful for establishing standards in interstitial fluid levels and tissue properties. The second aim will focus on evaluating the effects of vibration on fluid content and dynamics in the vocal folds. First, finite element modeling will be used to study the effects of vibration on fluid content and dynamics while varying elongation, subglottal pressure, capillary permeability and stiffness. Physiological validation of the model trends will be carried out on excised animal models. Finally, an animal model of inflammation due to prolonged vibration will be used to observe how edema might occur in vocal overuse. The third aim will focus on the effects of fluid content on vocal fold vibration. We will determine hydration levels at which the vocal folds are pathologically changed. In other words, when there is a significant change to phonation parameters such as phonation threshold pressure. Excised models will be used in this aim to study the biomechanical effects of dehydration and overhydration. In addition, acoustoelastography will be employed to study the change in stress distribution of the tissue with changes in fluid content.

项目总结/摘要 声音障碍影响着全世界数百万人。患者报告了许多负面的社会 发音困难的经济影响。适当的体液平衡对正常的声带功能至关重要。维护 声带组织中正常的液体水平确保了正常的生物力学和振动参数。潜在 对这种内稳态的干扰包括过度使用、误用、全身或表面脱水、创伤， 炎症这些扰动的结果可导致应力分布的变化、机械损伤， 和炎症。对组织的进一步损伤可能导致水肿或良性病变的形成。 这项建议的总体目标是评估声带流体稳态的贡献， 组织特性和振动生物力学导致组织损伤并最终导致水肿。结果将 解释振动力学在长时间发声过程中的变化。量化流体的方法 本提案中开发的离体和体内模型中的内容将提供有关流体的必要信息 内容和进一步我们的知识和理解的作用，流体在声带振动。知识 从这项研究中获得的是必要的，更全面的了解临床管理的声音 紊乱 这项研究的方法将涉及三个具体目标。第一个目标将侧重于 量化液体含量和组织性质。我们将采用四种新的技术，以喉：（1）组织 介电特性（TDP），组织含水量的量度;（2）光学相干断层扫描（OCT）， 方法来量化组织中的液体体积;（3）激光多普勒血流仪，通过一个测量血液流量 组织;以及（4）声弹性成像，组织的声学特性的测量，其与 应变和非线性相关的组织应力。这些方法的结果将有助于建立 间质液水平和组织性质的标准。第二个目标将侧重于评估 振动对流体的内容和动力学在声带。首先，将采用有限元建模来研究 振动对液体含量和动力学的影响，同时改变伸长率、声门下压、毛细血管 渗透性和硬度。将对切除的动物进行模型趋势的生理学验证 模型最后，将使用由于长时间振动引起的炎症的动物模型来观察如何 水肿可能发生在发声过度使用。第三个目标将集中在流体含量对声带的影响 振动.我们将确定声带病理改变的水化水平。换句 换句话说，当发声参数（例如发声阈值压力）发生显着变化时。 将使用切除的模型来研究脱水和过度水合的生物力学效应。在 此外，声弹性成像将用于研究组织应力分布的变化， 液体含量的变化。

项目成果

Study of spatiotemporal liquid dynamics in a vibrating vocal fold by using a self-oscillating poroelastic model.

使用自振荡多孔弹性模型研究振动声带中的时空液体动力学。

• DOI: 10.1121/10.0002163
• 发表时间: 2020
• 期刊: The Journal of the Acoustical Society of America
• 作者: Scholp,Austin;Jeddeloh,Caroline;Tao,Chao;Liu,Xiaojun;Dailey,SethH;Jiang,JackJ
• 通讯作者: Jiang,JackJ