Aerodynamic Study For Laryngeal Function Assessment Using Airflow Interruption Me

使用气流中断 Me 进行喉功能评估的空气动力学研究

• 批准号: 9134120
• 负责人: Jack J Jiang
• 金额: $ 30.9万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9134120
• 关键词: Acoustics; Affect; Aftercare; American; Biological Neural Networks; Botox; Cheek structure; Clinical; Computer Simulation; Data; Devices; Diagnostic; Disease; Dysphonia; Economics; Evaluation; Evidence based practice; Evidence based treatment; Family; Friends; Goals; Image; Individual; Injection of therapeutic agent; Interruption; Investigation; Laboratories; Larynx; Lead; Length; Lesion; Life; Location; Masks; Measurement; Measures; Mechanics; Methods; Modality; Modification; Monitor; Nature; Nodule; Operative Surgical Procedures; Outcome; Paralysed; Pathology; Pathway Analysis; Patient Monitoring; Patients; Phase; Phonation; Polyps; Production; Quality of life; Recruitment Activity; Reflex action; Research; Resistance; Role; Social Impacts; Societies; Spastic Dysphonias; Speed; System; Techniques; Time; Transducers; Treatment Efficacy; Treatment Protocols; Video Recording; Visual; Voice; Voice Disorders; Voice Quality; Work; auditory feedback; clinical application; common treatment; economic impact; effective therapy; glottis; improved; novel; pressure; profiles in patients; restraint; social; sound; success; trend; vibration; visual feedback; vocal cord; voice therapy

DESCRIPTION (provided by applicant): Voice disorders affect millions of Americans and have been targeted as a national priority for investigation. The impact of voice disorders on quality of life is significant; the ability to work, relate to friends and family, participate in social activties, and simply engage in everyday life becomes effortful, if not impossible, when one's voice is impaired. The multi-factorial nature of voice disorders necessitates that clinicians understand how the larynx functions in order to make appropriate treatment decisions. During phonation, the larynx serves as an energy transducer, transferring aerodynamic energy in the form of subglottal pressure (Ps) and airflow into acoustic energy in the form of sound. Noninvasive aerodynamic assessment is an objective and quantitative method of evaluating the inputs to voice production. The proposed research has two interrelated parts. In part I, research will focus on improving three methods of aerodynamic measurement developed in our laboratory: airflow interruption; incomplete airflow interruption; and airflow redirection. These methods have all been demonstrated to be accurate. Modifications will be made to the devices to allow for measurement of phonation threshold flow and phonation threshold power, two new parameters proposed by our laboratory that have been experimentally shown to be valuable. Enhancing these devices with additions such as auditory feedback, visual feedback, cheek restraints, and modified analysis techniques will also be investigated, potentially reducing intrasubject variability. We will also determine the optimal interruption length for measurement of Ps and determine how interruption affects vocal fold vibration by combining our aerodynamic assessment devices with high-speed video imaging. Elicitation of a reflex has hindered the widespread clinical application of airflow interruption. Visualizing the vocal folds during airflow interruption will allow us to determine if this reflex occurs at the larynx and if so, its precise latency. Data from part I will allow for selection of an improved method of aerodynamic assessment. In part II, the optimal system developed in part I will be used to evaluate and compare treatments for common voice disorders. The effect of polyp and nodule size on aerodynamic parameters will be evaluated; how aerodynamic parameters change as lesion size decreases will also be investigated. Pre- and post-treatment aerodynamic assessment will be performed to determine the effect of Botox injections on spasmodic dysphonia. We will also compare several common treatments for vocal fold paralysis. Though numerous treatments are available, an optimal treatment has yet to be developed. Real-time intraoperative measurements of vocal efficiency will be investigated as a means to optimize medialization laryngoplasty and arytenoid adduction. We will also determine the diagnostic power of each aerodynamic parameter individually and all parameters collectively. Preliminary observations suggest that aerodynamic measurements can improve assessment of voice disorders. Thus, the potential to improve understanding of normal and disordered voice production is great.

描述（由申请人提供）：声音障碍影响着数百万美国人，并已成为国家优先调查的目标。语音障碍对语音质量的影响

项目成果

Aerodynamic measures of glottal function: what extra can they tell us and how do they guide management?

• DOI: 10.1097/moo.0000000000000107
• 发表时间: 2014-12
• 期刊: Current opinion in otolaryngology & head and neck surgery
• 影响因子: 1.6
• 作者: Jiang JJ;Maytag AL
• 通讯作者: Maytag AL

Retest Reliability for Complete Airway Interruption Systems of Aerodynamic Measurement.

• DOI: 10.1016/j.jvoice.2020.02.024
• 发表时间: 2022-01
• 期刊: Journal of voice : official journal of the Voice Foundation
• 作者: Lamb JR;Schultz SA;Scholp AJ;Wendel ER;Jiang JJ
• 通讯作者: Jiang JJ

Phonation threshold flow measurements in normal and pathological phonation.

• DOI: 10.1002/lary.20165
• 发表时间: 2009-04
• 期刊: LARYNGOSCOPE
• 影响因子: 2.6
• 作者: Zhuang, Peiyun;Sprecher, Alicia J.;Hoffman, Matthew R.;Zhang, Yi;Fourakis, Marios;Jiang, Jack J.;Wei, Chun Sheng
• 通讯作者: Wei, Chun Sheng

Phonation threshold pressure estimation using electroglottography in an airflow redirection system.

• DOI: 10.1002/lary.20611
• 发表时间: 2009-12
• 期刊: LARYNGOSCOPE
• 影响因子: 2.6
• 作者: Rieves, Adam L.;Regner, Michael F.;Jiang, Jack J.
• 通讯作者: Jiang, Jack J.

New insights into mechanism of Eustachian tube ventilation based on cine computed tomography images.

• DOI: 10.1007/s00405-011-1829-y
• 发表时间: 2012-08
• 期刊: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
• 作者: McDonald MH;Hoffman MR;Gentry LR;Jiang JJ
• 通讯作者: Jiang JJ