The Spatiotemporal Vibratory Characteristics Of Pathological Vocal Folds

描述（由申请人提供）：在过去的十年中，声音产生的时间特性在喉生理学研究中得到了广泛的探讨。然而，这些研究显示缺乏关于无序语音产生的空间方面的信息。无序的声音产生涉及时间和空间特性。在台架模型上的时空分析证明了理解喉系统生理障碍的价值。本研究的总体目的是开发可行的临床应用的高速测量和时空分析方法来量化喉部疾病患者声带的振动特性。本建议书将提出五个项目。第一个项目将优化一系列用于临床高速影像数据的时空分析方法。我们建议用时空摄动分析、时空相关分析和特征模态分析来测量粘膜波。第二个项目将侧重于利用人类受试者的高速成像数据测量声带的生物力学参数。提出了一种基于同步的参数估计方法来确定人类声带的生物力学参数。第三个项目将采用高速成像测量和分析方法，通过记录正常人声带功能的振动特征来建立规范。第四个项目将探索喉病理的高速成像测量和分析，包括声带结节和息肉、喉麻痹、声带瘢痕、声带癌和急性喉炎。研究了时空分析参数在区分健康声音和紊乱声音方面的敏感性和特异性。第五个项目将采用先进的高速影像分析技术来评估声带小结和息肉、喉麻痹、声带瘢痕、声带癌和急性喉炎的治疗效果。

DESCRIPTION (provided by applicant): In the last decade, the temporal properties of voice production have been explored extensively in laryngeal physiology studies. However, these studies display a lack of information concerning the spatial aspect of disordered voice production. Disordered voice production involves both temporal and spatial properties. Spatiotemporal analysis on a bench model demonstrates the value of understanding physiological disorders in laryngeal systems. The overall aim of this study is to develop feasible clinical applications of high-speed measurements and spatiotemporal analysis methods to quantify the vibratory properties of vocal folds of patients with laryngeal diseases. Five projects will be proposed in this proposal. The first project will optimize a series of spatiotemporal analysis methods for clinical high-speed imaging data. We propose measuring the mucosal wave with spatiotemporal perturbation analysis, spatiotemporal correlation analysis, and eigenmode analysis. The second project will focus on measuring the biomechanical parameters of the vocal folds using high-speed imaging data of human subjects. A synchronization-based parameter estimation method is proposed to determine the biomechanical parameters of human vocal folds. The third project will apply high-speed imaging measurement and analysis methods to establish norms by documenting the vibratory characteristics of vocal function in normal subjects. The fourth project will explore the high-speed imaging measurement and analysis of laryngeal pathologies, including vocal nodules and polyps, laryngeal paralysis, vocal fold scarring, vocal fold cancer, and acute laryngitis. The sensitivity and specificity of spatiotemporal analysis parameters in distinguishing healthy voices from disordered voices will be investigated. The fifth project will employ the developed analysis of high-speed imaging to assess the treatment effects of vocal nodules and polyps, laryngeal paralysis, vocal fold scarring, vocal fold cancer, and acute laryngitis.