The Spatiotemporal Vibratory Characteristics Of Pathological Vocal Folds

描述(由申请人提供)：在过去的十年里，发声的时间特性在喉部生理学研究中得到了广泛的探索。然而，这些研究显示缺乏关于无序发声的空间方面的信息。无序的语音产生既涉及时间属性，也涉及空间属性。在长凳模型上的时空分析证明了理解喉系统生理性疾病的价值。这项研究的总体目标是开发高速测量和时空分析方法的可行临床应用，以量化喉部疾病患者声带的振动特性。这份提案将提出五个项目。第一个项目将优化一系列针对临床高速成像数据的时空分析方法。我们建议使用时空扰动分析、时空相关分析和本征模式分析来测量粘膜波。第二个项目将专注于使用人类受试者的高速成像数据来测量声带的生物力学参数。提出了一种基于同步的参数估计方法来确定人体声带的生物力学参数。第三个项目将应用高速成像测量和分析方法，通过记录正常受试者发声功能的振动特征来建立常模。第四个项目将探索喉部病理的高速成像测量和分析，包括声带小结和息肉、喉部瘫痪、声带疤痕、声带癌和急性喉炎。我们将研究时空分析参数在区分健康嗓音和紊乱嗓音方面的敏感性和特异性。第五个项目将使用开发的高速成像分析来评估声带小结和息肉、喉部瘫痪、声带疤痕、声带癌和急性喉炎的治疗效果。

DESCRIPTION (provided by applicant): In the last decade, the temporal properties of voice production have been explored extensively in laryngeal physiology studies. However, these studies display a lack of information concerning the spatial aspect of disordered voice production. Disordered voice production involves both temporal and spatial properties. Spatiotemporal analysis on a bench model demonstrates the value of understanding physiological disorders in laryngeal systems. The overall aim of this study is to develop feasible clinical applications of high-speed measurements and spatiotemporal analysis methods to quantify the vibratory properties of vocal folds of patients with laryngeal diseases. Five projects will be proposed in this proposal. The first project will optimize a series of spatiotemporal analysis methods for clinical high-speed imaging data. We propose measuring the mucosal wave with spatiotemporal perturbation analysis, spatiotemporal correlation analysis, and eigenmode analysis. The second project will focus on measuring the biomechanical parameters of the vocal folds using high-speed imaging data of human subjects. A synchronization-based parameter estimation method is proposed to determine the biomechanical parameters of human vocal folds. The third project will apply high-speed imaging measurement and analysis methods to establish norms by documenting the vibratory characteristics of vocal function in normal subjects. The fourth project will explore the high-speed imaging measurement and analysis of laryngeal pathologies, including vocal nodules and polyps, laryngeal paralysis, vocal fold scarring, vocal fold cancer, and acute laryngitis. The sensitivity and specificity of spatiotemporal analysis parameters in distinguishing healthy voices from disordered voices will be investigated. The fifth project will employ the developed analysis of high-speed imaging to assess the treatment effects of vocal nodules and polyps, laryngeal paralysis, vocal fold scarring, vocal fold cancer, and acute laryngitis.