Etiology of breast development in the BCERC network: role of socioeconomic status

BCERC 网络中乳房发育的病因学：社会经济地位的作用

• 批准号: 7941745
• 负责人: Dejana K Braithwaite
• 金额: $ 6.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7941745
• 关键词: 12 year old; Accounting; Adult; African; African American; Age; Age at Menarche; Area; Attenuated; Body fat; Body mass index; Breast; Breast Cancer Risk Factor; California; Chemicals; Chronic; Cohort Effect; Confounding Factors (Epidemiology); Crowding; Data; Data Analyses; Data Set; Databases; Development; Dose; Drops; Economic Factors; Economics; Environment; Environmental Risk Factor; Ethnic Origin; Ethnic group; Etiology; Event; Experimental Animal Model; Future; Genetic; Goals; Grant; Growth; Height; Hispanics; Historical Cohort Studies; Home environment; Household; Income; Life; Literature; Measures; Menarche; Minority; Mission; Nature; New York; Obesity; Ohio; Outcome; Ownership; Pattern; Play; Population Distributions; Predictive Value; Puberty; Public Health; Race; Relative (related person); Research; Research Personnel; Resources; Risk; Role; Sample Size; Site; Socioeconomic Factors; Socioeconomic Status; Techniques; Time; United States; Variant; Weight; abstracting; aged; base; cancer epidemiology; cancer health disparity; cancer risk; cohort; early onset; girls; high risk; improved; indexing; innovation; insight; longitudinal design; malignant breast neoplasm; meetings; novel; programs; prospective; pubertal timing; public health relevance; racial and ethnic; racial/ethnic difference; response; rural area; social; socioeconomics; trend; waist circumference

DESCRIPTION (provided by applicant): Etiology of breast development in the BCERC network: role of socioeconomic status Dejana Braithwaite, Robert A. Hiatt and BCERC Investigators Abstract This application is concerned with the role of socioeconomic status (SES) and race/ethnicity in the timing of breast development and menarche as an early life marker of breast cancer risk. Secular trends toward earlier age at the onset of breast development and menarche have spurred the creation of the Breast Cancer and the Environment Research Centers (BCERC). It has been established that African American and Hispanic girls mature earlier than their white counterparts but the reasons for this biologic change remain poorly understood. Currently, there are major information gaps on the determinants of pubertal onset among minorities. We hypothesize that social and economic factors may reflect upstream determinants of early puberty. In the network of three prospective multiethnic cohorts of girls (n=1,238) aged 6 to 8 years at baseline and actively followed for 4 years to date at three sites in the United States as part of the BCERC, we will determine whether previously unexplored socioeconomic factors (household income, parental educational attainment, home ownership, residential crowding, wealth) can explain some of the variation in the timing of pubertal outcomes across and within racial/ethnic groups. Our specific aims are to determine the nature and strength of the association between a wide array of SES indicators and pubertal onset (AIM 1) and whether socioeconomic factors modify the association between race/ethnicity and pubertal onset (AIM 2). The large sample size of the BCERC network, including the data already collected via extensive longitudinal assessments of a comprehensive array of chemical, physical, anthropometric, social and genetic factors in addition to serial exams of pubertal development make it a unique resource. Major strengths of the study are: 1) The hypothesis that socioeconomic status may play a role in pubertal onset has not been systematically explored; 2) Combining data from the three BCERC centers will improve external validity, making the findings more generalizable to all girls in the United States; 3) The cohorts have a substantial proportion of girls from low socioeconomic and minority backgrounds; 4) Large sample size, longitudinal design, detailed and accurately measured data, high retention rates and innovative hypotheses represent a much needed advance over existing research; 5) innovative statistical techniques such as CART have not been previously employed in the present area of research. The Small Grants in Cancer Epidemiology Program mechanism provides an ideal vehicle to accomplish the objective of this study, which is aligned with the NCI's mission to determine the underlying causes of cancer health disparities. PUBLIC HEALTH RELEVANCE: Narrative This application is concerned with the role of socioeconomic status (SES) and race/ethnicity in the timing of breast development and menarche as an early life marker of breast cancer risk. The decline in age at the onset of breast development and menarche that has been observed over the last few decades among girls in the United States is a major public health concern. These developments have spurred the creation of the Breast Cancer and the Environment Research Centers (BCERC). It has been established that African American and Hispanic girls mature earlier than their white counterparts but the reasons for this biologic change remain poorly understood. The possibility that social and economic factors may reflect upstream determinants of early puberty and account for racial/ethnic differences in this outcome has not been systematically evaluated. In the network of three prospective multiethnic cohorts of girls (n=1,238) aged 6 to 8 years at baseline and actively followed for 4 years to date at three sites in the United States as part of the BCERC, we will determine whether previously unexplored socioeconomic factors (household income, parental educational attainment, home ownership, residential crowding, wealth) can explain some of the variation in the timing of pubertal outcomes across and within racial/ethnic groups. To accomplish the goals of this project, we will: 1 Determine the nature and strength of the association between socioeconomic factors and pubertal onset (AIM 1) 2 Determine whether socioeconomic factors modify the association between race/ethnicity and pubertal onset (AIM 2). The large sample size of the BCERC network, including the data already collected via extensive longitudinal assessments of a comprehensive array of chemical, physical, anthropometric, social and genetic factors in addition to serial exams of pubertal development make it a unique resource. Major strengths of the study are: 1) The possibility that socioeconomic status may play a role in pubertal onset has not been systematically explored; 2) Combining data from the three BCERC centers will improve making the findings more generalizable to all girls in the United States; 3) The cohorts have a substantial proportion of girls from low socioeconomic and minority backgrounds; and 4) Large sample size, detailed and accurately measured data, high retention rates and innovative hypotheses represent a much needed advance over existing research. The Small Grants in Cancer Epidemiology Program mechanism provides an ideal vehicle to accomplish the objective of this study, which is aligned with the NCI's mission to determine the underlying causes of cancer health disparities.

描述（由申请人提供）：BCERC网络中乳房发育的病因学：社会经济地位的作用Dejana Braithwaite，Robert A. Hiatt和BCERC研究人员摘要本申请关注的是社会经济地位（SES）和种族/民族在乳房发育和月经初潮的时间作为乳腺癌风险的早期生命标志物中的作用。乳房发育和月经初潮开始的年龄越来越早，这一长期趋势促使了乳腺癌与环境研究中心（BCERC）的成立。已经确定，非洲裔美国人和西班牙裔女孩比她们的白色同龄人成熟得更早，但对这种生物变化的原因仍然知之甚少。目前，在少数群体青春期开始的决定因素方面存在重大信息差距。我们假设社会和经济因素可能反映了青春期提前的上游决定因素。作为BCERC的一部分，在基线时年龄为6至8岁的三个前瞻性多种族女孩队列（n= 1，238）的网络中，我们将确定以前未探索的社会经济因素是否与年龄相关。（家庭入息、父母教育程度、自置居所、住宅挤迫程度、财富）可以解释不同种族/族裔群体之间和内部青春期结果的时间差异。我们的具体目标是确定一系列SES指标与青春期开始（AIM 1）之间的关联的性质和强度，以及社会经济因素是否会改变种族/民族与青春期开始（AIM 2）之间的关联。BCERC网络的大样本量，包括通过对化学、物理、人体测量、社会和遗传因素的全面纵向评估以及青春期发育的系列检查收集的数据，使其成为一个独特的资源。该研究的主要优势是：1）社会经济地位可能在青春期开始中发挥作用的假设尚未得到系统的探讨; 2）合并来自BCERC三个中心的数据将提高外部效度，使研究结果更适用于美国所有女孩; 3）队列中有相当比例的女孩来自低社会经济和少数民族背景; 4）大样本量，纵向设计，详细和准确测量的数据，高保留率和创新的假设代表了一个急需的进步，超过现有的研究; 5）创新的统计技术，如CART以前没有在本研究领域使用。癌症流行病学项目的小额赠款机制为实现本研究的目标提供了一个理想的工具，该研究与NCI的使命一致，即确定癌症健康差异的根本原因。 公共卫生相关性：叙述本申请涉及社会经济地位（SES）和种族/民族在乳房发育和初潮的时间作为乳腺癌风险的早期生命标志物的作用。过去几十年来，在美国的女孩中观察到乳房发育和月经初潮开始时的年龄下降，这是一个主要的公共卫生问题。这些发展促使了乳腺癌和环境研究中心（BCERC）的成立。已经确定，非洲裔美国人和西班牙裔女孩比她们的白色同龄人成熟得更早，但对这种生物变化的原因仍然知之甚少。社会和经济因素可能反映青春期提前的上游决定因素，并解释这一结果的种族/民族差异的可能性尚未得到系统评价。作为BCERC的一部分，在基线时年龄为6至8岁的三个前瞻性多种族女孩队列（n= 1，238）的网络中，我们将确定以前未探索的社会经济因素是否与年龄相关。（家庭入息、父母教育程度、自置居所、住宅挤迫程度、财富）可以解释不同种族/族裔群体之间和内部青春期结果的时间差异。为了实现本项目的目标，我们将：1确定社会经济因素和青春期开始之间的关联的性质和强度（AIM 1）2确定社会经济因素是否改变种族/民族和青春期开始之间的关联（AIM 2）。BCERC网络的大样本量，包括通过对化学、物理、人体测量、社会和遗传因素的全面纵向评估以及青春期发育的系列检查收集的数据，使其成为一个独特的资源。该研究的主要优势是：1）社会经济地位可能在青春期开始中发挥作用的可能性尚未得到系统的探讨; 2）将来自BCERC三个中心的数据结合起来将使研究结果更适用于美国所有女孩; 3）队列中有相当大比例的女孩来自低社会经济和少数民族背景; 4）大样本量、详细和精确测量的数据、高保留率和创新的假设代表了现有研究急需的进步。癌症流行病学项目的小额赠款机制为实现本研究的目标提供了一个理想的工具，该研究与NCI的使命一致，即确定癌症健康差异的根本原因。