Cancer Control and Population Sciences Research Program

癌症控制与人口科学：摘要 佛罗里达大学健康癌症中心癌症控制和人口科学(CCPS)项目 (UFCC)由Braithwaite和Krieger领导。CCPS计划的目标是减少癌症负担 佛罗里达州中北部及更远地区的农村地区。CCPS计划的具体目标是：1)阐明分子， 癌症发病率和死亡率中的行为、社会、环境和其他危险因素；2)发展和 评估一级和二级癌症预防干预措施；以及3)解决癌症的独特需求 幸存者。研究活动由5个CCPS优先事项统一起来，以解决集水区的癌症负担 区域(CA)：a)社会决定因素和癌症差异；b)吸烟和其他烟草使用；c)分子和 成像标志物；d)肥胖、能量平衡和癌症；以及e)癌症和衰老的交集。捕捉 在佛罗里达大学(UF)的研究实力，CCPS汇集了48名成员，绘制了广泛的 来自20个系和10所学院的专业知识。CCPS组织有一种多学科的文化 与其他UFCC计划、共享资源、社区外联和参与(COE)、 以及癌症研究培训和教育，使翻译领域的研究变得卓越。 自2016年以来，该计划的主要成就包括评估#年乳腺癌筛查的绩效 老年妇女，开发新的癌症沟通策略，以增加结直肠癌筛查和 HPV疫苗接种率，进行研究，提高佛罗里达州烟草销售年龄，开发 预防诊断和治疗辐射的有害影响的辐射剂量工具，评估丙型肝炎 降低肝癌风险的治疗，并开发数字患者报告结果工具。自2016年以来， 计划成员发表了1114篇与癌症相关的出版物，其中约7%带有影响因素&>>10.CCPS成员 招募了6528名参与者进行干预试验，包括一项检查患者报告的务实临床试验 老年前列腺癌患者质子治疗的结果，以及13,064名非 介入研究。通过我们的努力，强大的协作非常明显，40%的计划内协作，29%的协作 跨计划出版物和73%的多机构出版物。CCPS成员持有1150万美元的外部同行- 审查资金(自2019年以来增长了48%)，NCI提供了370万美元。CCP导师培训了186名研究生 30名博士后，其中66%是女性，19%是代表不足的少数民族(URM)。协调中心的未来发展方向 与UFCC战略计划，Momentum 2027保持一致，寻求进一步的招聘，科学进步， 并在UFCC的研究专长和社区伙伴关系的基础上产生影响。由CA驱动 需求，未来的发展包括扩大烟草控制研究，癌症传播，以及 放映。CCP将解决老龄化与癌症、肥胖与癌症以及 社会决定因素对癌症结局的影响。CCPS将与COE合作，传播研究成果 CA及其他地区的调查结果和最佳实践。

CANCER CONTROL AND POPULATION SCIENCES (CCPS): ABSTRACT The Cancer Control and Population Sciences (CCPS) program at the University of Florida Health Cancer Center (UFHCC) is led by Braithwaite and Krieger. The goal of the CCPS program is to reduce the cancer burden in rural North Central Florida and beyond. The CCPS program’s specific aims are to: 1) Elucidate molecular, behavioral, social, environmental, and other risk factors in cancer incidence and mortality; 2) Develop and evaluate primary and secondary cancer prevention interventions; and 3) Address the unique needs of cancer survivors. Research activities are unified by 5 CCPS priorities that address the cancer burden of the catchment area (CA): a) social determinants and cancer disparities; b) smoking and other tobacco use; c) molecular and imaging markers; d) obesity, energy balance, and cancer; and e) the intersection of cancer and aging. To capture the research strengths at the University of Florida (UF), CCPS assembled 48 members drawing a wide range of expertise from 20 departments and 10 colleges. The organization of CCPS has a culture of multidisciplinary collaboration with other UFHCC programs, shared resources, Community Outreach and Engagement (COE), and Cancer Research Training and Education, enabling research excellence across the translational spectrum. Since 2016, key achievements of the program include evaluating the performance of breast cancer screening in older women, developing novel cancer communication strategies to increase colorectal cancer screening and HPV vaccine uptake, performing studies that informed raising the age of tobacco sale in Florida, developing radiation dosing tools to prevent harmful effects of diagnostic and therapeutic radiation, assessing Hepatitis C treatments that reduce liver cancer risk, and developing digital patient-reported outcome tools. Since 2016, program members published 1,114 cancer-relevant publications, ~7% with impact factors >10. CCPS members enrolled 6,528 participants on interventional trials, including a pragmatic clinical trial examining patient-reported outcomes following proton therapy among older men with prostate cancer, and 13,064 participants on non- interventional studies. Through our efforts, robust collaboration is evident with 40% intra-programmatic, 29% inter-programmatic, and 73% multi-institutional publications. CCPS members hold >$11.5M in external peer- reviewed funding (up 48% since 2019), with >$3.7M from the NCI. CCPS mentors trained 186 graduate students and 30 postdocs, of whom 66% are women and 19% underrepresented minorities (URM). CCPS future directions are aligned with the UFHCC strategic plan, Momentum 2027, seeking further recruitments, scientific progress, and impact building on the research expertise of the UFHCC and community partnerships. Driven by the CA needs, future development includes expansion of tobacco control research, cancer communication, and screening. CCPS will address the intersectional problems of aging and cancer, obesity and cancer, and the impact of social determinants on cancer outcomes. In partnership with COE, CCPS will disseminate research findings and best practices across the CA and beyond.