Cancer Control and Population Sciences Research Program

癌症控制与人口科学研究计划

• 批准号: 10625755
• 负责人: Dejana K Braithwaite
• 金额: $ 7.12万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625755
• 关键词: Abbreviations; Achievement; Address; Advocate; Age; Aging; Agriculture; Area; Arts; Behavioral; Biological Sciences; Biomedical Research; Biometry; Black race; Breast; Breast Cancer Detection; Cancer Biology; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Etiology; Cancer Prevention Intervention; Cancer Survivor; Catchment Area; Clinical Sciences; Collaborations; Colorectal; Communication; Communities; Community Outreach; Confocal Microscopy; Dentistry; Development; Diagnostic; Diet; Discipline of Nursing; Disparity; Dissemination and Implementation; Early Diagnosis; Elderly; Electronic Health Record; Engineering; Enrollment; Equilibrium; Etiology; Extramural Activities; Florida; Flow Cytometry; Funding; Future; Goals; Grant; Guidelines; Health; Health Occupations; Hepatitis C Therapy; Hispanic; Human; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papilloma Virus-Related Malignant Neoplasm; Immune response; Incidence; Informatics; Institution; Interdisciplinary Study; Intervention; Intervention Studies; Intervention Trial; Journalism; Last Name; Late Effects; Lung; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of prostate; Medicine; Mentors; Molecular; Not Hispanic or Latino; Obesity; Observational Study; Outcome; Participant; Patient Outcomes Assessments; Peer Review; Performance; Pharmacy facility; Physical activity; Policies; Population; Population Heterogeneity; Population Sciences; Postdoctoral Fellow; Pragmatic clinical trial; Prevention program; Prevention strategy; Primary Cancer Prevention; Public Health; Publications; Publishing; Radiation; Radiation Dose Unit; Research; Research Activity; Research Design; Research Personnel; Resource Sharing; Risk Factors; Rural; Rural Population; Sales; Science; Screening for cancer; Secondary Cancer Prevention; Smoking; Strategic Planning; Survivors; Symptoms; Testing; Therapeutic; Tobacco; Tobacco Control Research; Tobacco use; Training; Training and Education; Translating; Translational Research; Underrepresented Minority; Underserved Population; Universities; Woman; anticancer research; cancer health disparity; cancer imaging; cancer prevention; cancer risk; cancer therapy; clinical practice; clinical trial enrollment; college; colorectal cancer screening; community engaged research; community engagement; community partnership; digital; digital health; effectiveness trial; efficacy trial; energy balance; ethnic minority; graduate student; high risk; human old age (65+); imaging biomarker; implementation science; innovation; medically underserved population; member; modifiable risk; molecular marker; mortality; next generation sequencing; novel; older men; older women; patient engagement; personalized intervention; pragmatic trial; prevent; programs; proton therapy; racial minority; recruit; rural counties; scale up; screening; social; social determinants; survivorship; tool; translational pipeline; treatment response; trial design; tumorigenesis; vaccine acceptance

CANCER CONTROL AND POPULATION SCIENCES (CCPS): ABSTRACT The Cancer Control and Population Sciences (CCPS) program at the University of Florida Health Cancer Center (UFHCC) is led by Braithwaite and Krieger. The goal of the CCPS program is to reduce the cancer burden in rural North Central Florida and beyond. The CCPS program’s specific aims are to: 1) Elucidate molecular, behavioral, social, environmental, and other risk factors in cancer incidence and mortality; 2) Develop and evaluate primary and secondary cancer prevention interventions; and 3) Address the unique needs of cancer survivors. Research activities are unified by 5 CCPS priorities that address the cancer burden of the catchment area (CA): a) social determinants and cancer disparities; b) smoking and other tobacco use; c) molecular and imaging markers; d) obesity, energy balance, and cancer; and e) the intersection of cancer and aging. To capture the research strengths at the University of Florida (UF), CCPS assembled 48 members drawing a wide range of expertise from 20 departments and 10 colleges. The organization of CCPS has a culture of multidisciplinary collaboration with other UFHCC programs, shared resources, Community Outreach and Engagement (COE), and Cancer Research Training and Education, enabling research excellence across the translational spectrum. Since 2016, key achievements of the program include evaluating the performance of breast cancer screening in older women, developing novel cancer communication strategies to increase colorectal cancer screening and HPV vaccine uptake, performing studies that informed raising the age of tobacco sale in Florida, developing radiation dosing tools to prevent harmful effects of diagnostic and therapeutic radiation, assessing Hepatitis C treatments that reduce liver cancer risk, and developing digital patient-reported outcome tools. Since 2016, program members published 1,114 cancer-relevant publications, ~7% with impact factors >10. CCPS members enrolled 6,528 participants on interventional trials, including a pragmatic clinical trial examining patient-reported outcomes following proton therapy among older men with prostate cancer, and 13,064 participants on non- interventional studies. Through our efforts, robust collaboration is evident with 40% intra-programmatic, 29% inter-programmatic, and 73% multi-institutional publications. CCPS members hold >$11.5M in external peer- reviewed funding (up 48% since 2019), with >$3.7M from the NCI. CCPS mentors trained 186 graduate students and 30 postdocs, of whom 66% are women and 19% underrepresented minorities (URM). CCPS future directions are aligned with the UFHCC strategic plan, Momentum 2027, seeking further recruitments, scientific progress, and impact building on the research expertise of the UFHCC and community partnerships. Driven by the CA needs, future development includes expansion of tobacco control research, cancer communication, and screening. CCPS will address the intersectional problems of aging and cancer, obesity and cancer, and the impact of social determinants on cancer outcomes. In partnership with COE, CCPS will disseminate research findings and best practices across the CA and beyond.

癌症控制与人口科学（CCPS）：摘要 佛罗里达大学健康癌症中心的癌症控制和人口科学（CCPS）项目 UFHCC由Braithwaite和Krieger领导。CCPS计划的目标是减少癌症负担， 佛罗里达中北部及更远的乡村。CCPS计划的具体目标是：1）阐明分子， 行为、社会、环境和其他风险因素在癌症发病率和死亡率中的作用; 2）发展和 评估初级和二级癌症预防干预措施; 3）满足癌症的独特需求 幸存者研究活动由5个CCPS优先事项统一，解决集水区的癌症负担 区域（CA）：a）社会决定因素和癌症差异; B）吸烟和其他烟草使用; c）分子和 成像标记物; d）肥胖、能量平衡和癌症;以及e）癌症和衰老的交叉。捕捉 在佛罗里达大学（UF）的研究实力，CCPS聚集了48名成员，绘制了广泛的， 来自20个部门和10个学院的专业知识。CCPS的组织具有多学科的文化 与其他UFHCC计划合作，共享资源，社区外展和参与（COE）， 和癌症研究培训和教育，使研究卓越的整个转化谱。 自2016年以来，该计划的主要成就包括评估乳腺癌筛查的表现， 老年妇女，开发新的癌症沟通策略，以增加结直肠癌筛查， HPV疫苗摄取，进行研究，告知提高烟草销售年龄在佛罗里达，发展 预防诊断和治疗辐射有害影响的辐射剂量工具，评估丙型肝炎 降低肝癌风险的治疗，以及开发数字化患者报告结果工具。2016年以来， 项目成员发表了1，114篇癌症相关出版物，约7%的影响因子>10。CCPS成员 在干预性试验中招募了6，528名参与者，包括一项实用的临床试验，检查患者报告的 质子治疗老年男性前列腺癌后的结果，以及13，064名非质子治疗的参与者。 干预性研究。通过我们的努力，有力的合作是显而易见的，40%的项目内，29%的项目外， 计划间出版物和73%的多机构出版物。CCPS成员持有超过1150万美元的外部同行- 审查了资金（自2019年以来增长了48%），NCI提供了超过370万美元。CCPS导师培训了186名研究生 和30名博士后，其中66%是女性，19%是少数民族（URM）。CCPS未来方向 与UFHCC战略计划Momentum 2027保持一致，寻求进一步的招聘，科学进步， 和UFHCC和社区伙伴关系的研究专业知识的影响建设。由CA驱动 需要，未来的发展包括扩大烟草控制研究，癌症交流， 筛选CCPS将解决老龄化和癌症，肥胖和癌症， 社会决定因素对癌症结果的影响。与COE合作，CCPS将传播研究成果 在整个CA和其他领域的调查结果和最佳实践。