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Radiologists' performance in digital mammography and breast tomosynthesis

放射科医生在数字乳房X线摄影和乳腺断层合成方面的表现

基本信息

批准号：
7899820
负责人：
ANDREW DOUGLAS ARNOLD MAIDMENT
金额：
$ 7.92万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2012-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Clinical Feasibility of Digital Breast Tomosynthesis: Analysis of Observer Performance Background: Digital breast tomosynthesis (DBT) is considered the latest and most promising development in breast cancer imaging. In clinical pilot studies DBT has demonstrated higher sensitivity and specificity over projection mammography, which is presently the breast cancer screening tool of choice. Importantly, DBT will be provided at a relatively modest premium compared to existing digital mammography (DM) systems. For these reasons it has been widely suggested that DBT will replace DM in the diagnosis of breast cancer; some further believe that DBT may replace mammography in screening breast cancer. A practical concern for implementation of DBT is the radiologists' review time because DBT generates approximately 50 times more images than mammography. An increase in review time might significantly impact the breast cancer screening capacity and thus access to screening. Objective: Our aim is to obtain insight into the likely success of DBT as the population breast cancer screening modality of choice by comparing the radiologists' performance to interpret DBT images with DM images for the detection of breast cancer using time-controlled viewing experiments. The time-controlled viewing conditions will provide an unbiased perceptual viewing situation to compare whether 3D DBT facilitates perceptual recognition of breast cancers compared to 2D DM. We will also record the eye positions of radiologists as they view DBT and DM cases. The eye position analyses will provide a rigorous metric that will enable the quantitative measurement of the radiologists' performance. These will help to understand the current status of review issues so that they can be better addressed in future studies. Specific Aims (SA): SA1: Develop a platform to display DBT and DM cases under time-controlled viewing conditions. SA2: Compare for DBT and DM the radiologists' breast cancers detection performance under time-controlled viewing conditions and analyze the eye positions. Study Design: SA1: Task 1: We will modify our existing display hardware and software to allow equally short presentation times (2 s and 4 s) for DBT and DM images. Task 2: We will design a graphical user interface for the radiologists to report their decisions after each time-controlled viewing. SA2: Task 1: An experienced MQSA-certified radiologist will select a set of paired DBT and DM images of 100 breasts. Task 2: Four experienced MQSA-certified radiologists will review the images during short time-controlled presentations while their eye positions are tracked. Task 3: We will process the eye-position data. Task 4: We will compare the radiologists' breast cancer detection performance and the analyses on the eye-position data between DBT and DM. PUBLIC HEALTH RELEVANCE: This proposal aims to investigate the potential of digital breast tomosynthesis (DBT) as a population screening modality. We will focus on comparing radiologists' performance to rapidly interpret DBT cross-sectional images in stack mode with DM projection images for the detection of breast cancer using short time-controlled viewing experiments.

描述（由申请人提供）：数字乳腺断层合成摄影的临床可行性：观察者性能分析背景：数字乳腺断层合成摄影（DBT）被认为是乳腺癌成像的最新和最有前途的发展。在临床试点研究中，DBT已证明比投影乳腺X线摄影更高的灵敏度和特异性，后者目前是乳腺癌筛查的首选工具。重要的是，与现有的数字乳腺X射线摄影（DM）系统相比，DBT将以相对适度的溢价提供。由于这些原因，人们普遍认为DBT将取代DM诊断乳腺癌;有些人进一步认为DBT可能取代乳腺X线摄影筛查乳腺癌。实施DBT的一个实际问题是放射科医生的审查时间，因为DBT生成的图像大约是乳房X线摄影的50倍。审查时间的增加可能会严重影响乳腺癌筛查能力，从而影响筛查的获得。目的：我们的目标是通过使用时间控制观察实验比较放射科医生解释DBT图像与DM图像检测乳腺癌的表现，深入了解DBT作为人群乳腺癌筛查方式的可能成功。时间控制的观看条件将提供无偏见的感知观看情况，以比较3D DBT与2D DM相比是否有助于乳腺癌的感知识别。我们还将记录放射科医生在查看DBT和DM病例时的眼睛位置。眼位分析将提供一个严格的度量标准，使放射科医生的性能的定量测量。这将有助于了解审查问题的现状，以便在未来的研究中更好地解决这些问题。具体目标（SA）：SA 1：开发一个平台，在时间控制的查看条件下显示DBT和DM病例。SA2：比较DBT和DM的放射科医生的乳腺癌检测性能在时间控制的观察条件下，并分析眼睛的位置。研究设计：SA1：任务一：我们将修改现有的显示硬件和软件，使DBT和DM图像的显示时间同样短（2秒和4秒）。任务2：我们将为放射科医生设计一个图形用户界面，以便在每次时间控制查看后报告他们的决定。SA 2：任务1：经验丰富的MQSA认证放射科医师将选择100个乳房的一组配对DBT和DM图像。任务二：四名经验丰富的MQSA认证的放射科医生将在短时间控制的演示过程中审查图像，同时跟踪他们的眼睛位置。任务3：我们将处理眼睛位置数据。任务4：我们将比较放射科医师在DBT和DM之间的乳腺癌检测性能和对眼位数据的分析。公共卫生相关性：该提案旨在研究数字乳腺断层合成摄影（DBT）作为人群筛查方式的潜力。我们将重点比较放射科医生的性能，快速解释DBT横截面图像的堆栈模式与DM投影图像检测乳腺癌使用短时间控制的观察实验。