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Urinary Incontinence in Breast Cancer Survivors: A Controlled Comparsion

乳腺癌幸存者的尿失禁：对照比较

基本信息

批准号：
7901444
负责人：
KRISTINE ANNE DONOVAN
金额：
$ 8.35万
依托单位：
H. LEE MOFFITT CANCER CTR & RES INST
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7901444
关键词：
Address Age Behavior Behavior Therapy Bladder Breast Cancer Treatment Cancer Survivor Data Disease Early Diagnosis Effectiveness of Interventions Ethnic Origin Extravasation Failure Genitourinary system Health Incidence Incontinence Intervention Late Effects Left Life Longitudinal Studies Malignant Neoplasms Measures Menopausal Symptom Menopause Moods Outcome Participant Personal Satisfaction Prevalence Prevention Public Health Publishing Quality of life Race Randomized Controlled Trials Recording of previous events Reporting Research Sampling Self Management Severities Sex Functioning Sleep Stress Survivors Symptoms Time Urinary Incontinence Urine Woman abstracting clinical care clinically significant design health related quality of life help-seeking behavior innovation instrument interest malignant breast neoplasm prospective public health relevance survivorship therapy development urinary

项目摘要

DESCRIPTION (provided by applicant): ABSTRACT As a result of ongoing advances in early detection and treatment for breast cancer, interest has shifted increasingly to include the prevention and treatment of long-term and late effects of the disease. Consistent with this, a large body of research has documented the prevalence and severity of menopausal symptoms and their impact on quality of life in breast cancer survivors (BC+ survivors). Urinary incontinence (UI), or the involuntary leakage of urine, is a genitourinary symptom commonly associated with the menopausal transition. Previous studies of BC+ survivors indicate that between 28% and 55% of BC+ survivors report some symptom of UI. Studies have also demonstrated a relationship between UI and poorer health-related quality of life in survivorship. However, previous studies have been limited conceptually and methodologically and likely are an underestimate of the prevalence, severity and impact of UI on quality of life in BC+ survivors. Given that UI may significantly impact survivors' quality of life and may worsen over time if not treated, failure to assess and treat these symptoms may have long-term implications for the health and well-being of BC+ survivors. As well, the dearth of information available on UI outcomes, the impact of these outcomes on BC+ survivors' daily lives, and survivors' efforts to manage symptoms means that interventions to address UI in survivorship are likely to be incomplete and ineffective. To address the limitations of prior research and to advance our understanding of UI in BC+ survivors, we propose an innovative study of women with a history of breast cancer and an age-, race-, and ethnicity-matched comparison sample of women with no history of cancer (CA- participants). Participants will complete a battery of standardized, ecologically valid instruments designed to assess UI, UI outcomes and incontinence-related quality of life outcomes. Participants will also complete an assessment of self-management and help-seeking behaviors. These data will be used to address the following specific aims: 1) To estimate the prevalence of UI in women with a history of breast cancer compared to women with no history of cancer matched for age, race, and ethnicity; 2) To explore the relationship between UI severity and other UI outcomes to quality of life in BC+ survivors and matched CA- participants; and 3) To identify the self- management and help-seeking behaviors used by BC+ survivors to manage UI. The proposed study is expected to yield results which are both theoretically and clinically significant. In terms of theoretical significance, the study is expected to yield a more complete understanding of UI in BC+ survivors, its impact on survivors' quality of life, and survivors' efforts to manage UI symptoms. It is also expected to provide support for the conduct of a prospective, longitudinal study of UI incidence in BC+ survivors. In terms of clinical significance, the study will yield the empirical evidence necessary to guide the development of an intervention to treat UI in BC+ survivors. Taken as a whole, the proposed study is expected to have significant implications for clinical care in survivorship by leading to the design of a randomized controlled trial of the intervention. PUBLIC HEALTH RELEVANCE: Urinary incontinence is increasingly recognized as a socially disabling condition that can have a profound impact on quality of life. Although there is preliminary evidence of the prevalence of urinary incontinence in breast cancer survivors, there is a dearth of information available on types of urinary incontinence in breast cancer survivors, the severity of urinary incontinence in survivors, its impact on survivors' quality of life, and survivors' efforts to manage symptoms. The proposed research plan is expected to have implications for public health by yielding a complete understanding of urinary incontinence in breast cancer survivors and its impact on survivors' quality of life so that interventions to address the condition are relevant and effective.

描述（由申请人提供）：摘要由于乳腺癌早期检测和治疗方面不断取得进展，人们的兴趣日益转向包括预防和治疗该疾病的长期和晚期影响。与此相一致的是，大量研究记录了更年期症状的患病率和严重程度及其对乳腺癌幸存者（BC+幸存者）生活质量的影响。尿失禁 (UI) 或尿液不自主漏出，是一种通常与绝经过渡相关的泌尿生殖系统症状。先前对 BC+ 幸存者的研究表明，28% 至 55% 的 BC+ 幸存者报告有一些 UI 症状。研究还表明，UI 与幸存者较差的健康相关生活质量之间存在关系。然而，之前的研究在概念和方法上都受到限制，并且可能低估了 UI 的患病率、严重程度以及对 BC+ 幸存者生活质量的影响。鉴于 UI 可能会严重影响幸存者的生活质量，并且如果不治疗，情况可能会随着时间的推移而恶化，因此未能评估和治疗这些症状可能会对 BC+ 幸存者的健康和福祉产生长期影响。此外，缺乏关于 UI 结果的可用信息、这些结果对 BC+ 幸存者日常生活的影响以及幸存者控制症状的努力，意味着解决幸存者 UI 的干预措施可能不完整且无效。为了解决先前研究的局限性并增进我们对 BC+ 幸存者 UI 的理解，我们提出了一项针对有乳腺癌病史的女性的创新研究，以及无癌症病史的女性（CA-参与者）的年龄、种族和民族匹配的比较样本。参与者将完成一系列标准化、生态有效的工具，旨在评估 UI、UI 结果和失禁相关的生活质量结果。参与者还将完成自我管理和寻求帮助行为的评估。这些数据将用于实现以下具体目标： 1) 估计有乳腺癌病史的女性与没有癌症病史的女性相比，年龄、种族和民族相匹配的 UI 患病率； 2) 探讨 UI 严重程度和其他 UI 结果与 BC+ 幸存者和匹配的 CA- 参与者生活质量之间的关系； 3) 识别 BC+ 幸存者用于管理 UI 的自我管理和寻求帮助行为。拟议的研究预计将产生具有理论和临床意义的结果。就理论意义而言，该研究有望更全面地了解 BC+ 幸存者的 UI、其对幸存者生活质量的影响以及幸存者控制 UI 症状的努力。它还有望为 BC+ 幸存者 UI 发生率的前瞻性纵向研究提供支持。就临床意义而言，该研究将提供必要的经验证据，以指导开发治疗 BC+ 幸存者 UI 的干预措施。总体而言，拟议的研究预计将通过设计干预措施的随机对照试验，对生存的临床护理产生重大影响。公众健康相关性：尿失禁越来越被认为是一种社会残疾状况，可能对生活质量产生深远影响。尽管有初步证据表明乳腺癌幸存者尿失禁的患病率，但关于乳腺癌幸存者尿失禁的类型、幸存者尿失禁的严重程度、尿失禁对幸存者生活质量的影响以及幸存者控制症状的努力的信息还很缺乏。拟议的研究计划预计将通过全面了解乳腺癌幸存者的尿失禁及其对幸存者生活质量的影响而对公共健康产生影响，从而使解决该问题的干预措施具有相关性和有效性。