Urinary Incontinence in Breast Cancer Survivors: A Controlled Comparsion

乳腺癌幸存者的尿失禁：对照比较

• 批准号: 7753028
• 负责人: KRISTINE ANNE DONOVAN
• 金额: $ 8.35万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7753028
• 关键词: Address; Age; Behavior; Behavior Therapy; Bladder; Breast Cancer Treatment; Cancer Survivor; Data; Disease; Early Diagnosis; Effectiveness of Interventions; Ethnic Origin; Extravasation; Failure; Genitourinary system; Health; Incidence; Incontinence; Intervention; Late Effects; Left; Life; Longitudinal Studies; Malignant Neoplasms; Measures; Menopausal Symptom; Menopause; Moods; Outcome; Participant; Personal Satisfaction; Prevalence; Prevention; Public Health; Publishing; Quality of life; Race; Randomized Controlled Trials; Recording of previous events; Reporting; Research; Sampling; Self Management; Severities; Sex Functioning; Sleep; Stress; Survivors; Symptoms; Time; Urinary Incontinence; Urine; Woman; abstracting; clinical care; clinically significant; design; health related quality of life; help-seeking behavior; innovation; instrument; interest; malignant breast neoplasm; prospective; public health relevance; survivorship; therapy development; urinary

DESCRIPTION (provided by applicant): ABSTRACT As a result of ongoing advances in early detection and treatment for breast cancer, interest has shifted increasingly to include the prevention and treatment of long-term and late effects of the disease. Consistent with this, a large body of research has documented the prevalence and severity of menopausal symptoms and their impact on quality of life in breast cancer survivors (BC+ survivors). Urinary incontinence (UI), or the involuntary leakage of urine, is a genitourinary symptom commonly associated with the menopausal transition. Previous studies of BC+ survivors indicate that between 28% and 55% of BC+ survivors report some symptom of UI. Studies have also demonstrated a relationship between UI and poorer health-related quality of life in survivorship. However, previous studies have been limited conceptually and methodologically and likely are an underestimate of the prevalence, severity and impact of UI on quality of life in BC+ survivors. Given that UI may significantly impact survivors' quality of life and may worsen over time if not treated, failure to assess and treat these symptoms may have long-term implications for the health and well-being of BC+ survivors. As well, the dearth of information available on UI outcomes, the impact of these outcomes on BC+ survivors' daily lives, and survivors' efforts to manage symptoms means that interventions to address UI in survivorship are likely to be incomplete and ineffective. To address the limitations of prior research and to advance our understanding of UI in BC+ survivors, we propose an innovative study of women with a history of breast cancer and an age-, race-, and ethnicity-matched comparison sample of women with no history of cancer (CA- participants). Participants will complete a battery of standardized, ecologically valid instruments designed to assess UI, UI outcomes and incontinence-related quality of life outcomes. Participants will also complete an assessment of self-management and help-seeking behaviors. These data will be used to address the following specific aims: 1) To estimate the prevalence of UI in women with a history of breast cancer compared to women with no history of cancer matched for age, race, and ethnicity; 2) To explore the relationship between UI severity and other UI outcomes to quality of life in BC+ survivors and matched CA- participants; and 3) To identify the self- management and help-seeking behaviors used by BC+ survivors to manage UI. The proposed study is expected to yield results which are both theoretically and clinically significant. In terms of theoretical significance, the study is expected to yield a more complete understanding of UI in BC+ survivors, its impact on survivors' quality of life, and survivors' efforts to manage UI symptoms. It is also expected to provide support for the conduct of a prospective, longitudinal study of UI incidence in BC+ survivors. In terms of clinical significance, the study will yield the empirical evidence necessary to guide the development of an intervention to treat UI in BC+ survivors. Taken as a whole, the proposed study is expected to have significant implications for clinical care in survivorship by leading to the design of a randomized controlled trial of the intervention. PUBLIC HEALTH RELEVANCE: Urinary incontinence is increasingly recognized as a socially disabling condition that can have a profound impact on quality of life. Although there is preliminary evidence of the prevalence of urinary incontinence in breast cancer survivors, there is a dearth of information available on types of urinary incontinence in breast cancer survivors, the severity of urinary incontinence in survivors, its impact on survivors' quality of life, and survivors' efforts to manage symptoms. The proposed research plan is expected to have implications for public health by yielding a complete understanding of urinary incontinence in breast cancer survivors and its impact on survivors' quality of life so that interventions to address the condition are relevant and effective.

描述（由申请人提供）：摘要由于乳腺癌的早期检测和治疗的不断进步，人们的兴趣越来越多地转移到包括预防和治疗疾病的长期和晚期影响。与此相一致，大量研究记录了绝经期症状的患病率和严重程度及其对乳腺癌幸存者（BC+幸存者）生活质量的影响。尿失禁（UI），或尿液的不自主泄漏，是一种泌尿生殖系统症状，通常与绝经过渡期。先前对BC+幸存者的研究表明，28%至55%的BC+幸存者报告了UI的一些症状。研究还表明UI与生存率中健康相关生活质量较差之间存在关系。然而，以前的研究在概念上和方法上受到限制，并且可能低估了UI对BC+幸存者生活质量的患病率，严重程度和影响。鉴于UI可能会显著影响幸存者的生活质量，并且如果不治疗，可能会随着时间的推移而恶化，未能评估和治疗这些症状可能会对BC+幸存者的健康和福祉产生长期影响。此外，缺乏关于UI结果的信息，这些结果对BC+幸存者日常生活的影响，以及幸存者管理症状的努力意味着解决生存中UI的干预措施可能是不完整和无效的。为了解决先前研究的局限性，并促进我们对BC+幸存者UI的理解，我们提出了一项对有乳腺癌病史的女性和年龄，种族和种族匹配的比较样本的女性没有癌症史（CA-参与者）的创新研究。参与者将完成一系列标准化的、生态有效的工具，这些工具旨在评估UI、UI结局和失禁相关的生活质量结局。参与者还将完成自我管理和寻求帮助行为的评估。这些数据将用于解决以下具体目标：1）估计与年龄、人种和种族匹配的无癌症病史女性相比，有乳腺癌病史女性的UI患病率; 2）探索BC+幸存者和匹配的CA-参与者中UI严重程度和其他UI结局与生活质量之间的关系;（3）了解BC+幸存者在管理UI时的自我管理和求助行为。预计拟议的研究将产生具有理论和临床意义的结果。就理论意义而言，该研究有望更全面地了解BC+幸存者的UI，其对幸存者生活质量的影响以及幸存者管理UI症状的努力。预计还将为BC+幸存者UI发生率的前瞻性纵向研究提供支持。在临床意义方面，该研究将产生必要的经验证据，以指导开发治疗BC+幸存者UI的干预措施。作为一个整体，拟议的研究预计将有显着的影响，临床护理的生存率，导致设计的随机对照试验的干预。 公共卫生相关性：尿失禁越来越多地被认为是一种社会残疾的条件，可以对生活质量产生深远的影响。虽然有初步证据表明乳腺癌幸存者中尿失禁的患病率，但关于乳腺癌幸存者尿失禁的类型，幸存者尿失禁的严重程度，其对幸存者生活质量的影响以及幸存者管理症状的努力的信息缺乏。拟议的研究计划预计将对公共卫生产生影响，通过全面了解乳腺癌幸存者的尿失禁及其对幸存者生活质量的影响，以便采取相关和有效的干预措施来解决这种情况。