Protein modules for systematic analysis of cellular signalling pathways

用于系统分析细胞信号通路的蛋白质模块

• 批准号: G0700076/1
• 负责人: A Barclay
• 金额: $ 13.07万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700076%2F1
• 关键词: Protein; modules; systematic; analysis; cellular

Higher organisms are characterised by complex interactions between cells such as normal white blood cells that mediate immunity and abnormal cells such as in cancer. Following these interactions, signals are transmitted through interactions of many proteins, to control cell activities such as division, migration. Some of these controls fail in cancer. Thus there is considerable interest in deciphering these interactions but with the genome projects we realise that there are many proteins involved. This project utilises high throughput methods developed at the Oxford protein production Facility to provide panels of these proteins to researchers. They can then identify interactions in normal and abnormal cells and then work out how these signals are transmitted. Understanding these signals has implications for diseases such as cancer when cells grow out of control and autoimmune diseases where cells that can interact with self tissues are incorrectly controlled. Thus these interactions could be targets for therapies in the longer term.

高等生物体的特点是细胞（例如介导免疫的正常白细胞）与异常细胞（例如癌症）之间复杂的相互作用。在这些相互作用之后，信号通过许多蛋白质的相互作用传递，以控制细胞活动，例如分裂、迁移。其中一些控制措施在癌症方面失败了。因此，人们对破译这些相互作用非常感兴趣，但通过基因组计划，我们意识到涉及许多蛋白质。该项目利用牛津蛋白质生产设施开发的高通量方法为研究人员提供这些蛋白质的组合。然后他们可以识别正常和异常细胞中的相互作用，然后弄清楚这些信号是如何传递的。了解这些信号对于癌症等疾病（细胞生长失控）和自身免疫性疾病（可以与自身组织相互作用的细胞受到错误控制）具有重要意义。因此，从长远来看，这些相互作用可能成为治疗的目标。