The molecular basis for CD200R and SIRP paired receptor family function

CD200R 和 SIRP 配对受体家族功能的分子基础

• 批准号: G9826026-E03/1
• 负责人: A Barclay
• 金额: $ 251.7万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G9826026-E03%2F1
• 关键词: molecular; basis; CD200R; SIRP; paired

The immune system is remarkable in that it can recognise foreign materials such as bacteria and viruses without having encountered them before and make a measured response that leads to their elimination. It can distinguish between small infections at the site of, for example a bite, from a viral infection like influenza that calls for all the power of the immune system to be mobilised. This control is mediated by white blood cells patrolling the body waiting to react. The nature of the responses is highly controlled and this involves interactions of proteins at the surface of the blood cells with other cells. This proposal looks at one class of proteins called paired receptors that have been implicated in virus defence and have the intriguing property that they can give very different signals although the bit that recognises other cells is quite similar. These paired receptors are evolving very fast and the hypothesis is that bacteria and viruses might bind them directly and therefore affect responses to them and also the immune system in general. The aim is to understand the mechanisms involved at a molecular level for this interaction. The use of quantitative molecular analysis in this study will identify parameters involved in determining the signal produced with relevance for therapies involving this type of target and for the general understanding of the immune system. Thus it will have implications in understanding and treating diseases like cancer, infectious diseases and autoimmune disease such as arthritis, diabetes.

免疫系统的非凡之处在于，它可以识别细菌和病毒等异物，而不是以前遇到它们，并做出有节制的反应，导致它们被清除。它可以区分被叮咬部位的小感染和像流感这样的病毒感染，后者需要调动免疫系统的所有力量。这种控制是通过白细胞在体内巡逻等待反应来实现的。这种反应的性质是高度可控的，这涉及到血细胞表面的蛋白质与其他细胞的相互作用。这项提议着眼于一类被称为配对受体的蛋白质，它们与病毒防御有关，具有耐人寻味的特性，即它们可以发出截然不同的信号，尽管识别其他细胞的片段非常相似。这些成对的受体进化得非常快，假设细菌和病毒可能直接结合它们，从而影响对它们的反应，也影响整个免疫系统。其目的是在分子水平上了解这种相互作用的机制。在这项研究中使用定量分子分析将确定涉及确定与涉及这类靶点的治疗和对免疫系统的一般了解相关的信号所涉及的参数。因此，它将对理解和治疗癌症、传染病和自身免疫性疾病如关节炎、糖尿病等具有重要意义。