Allergies and pancreatic cancer: A pooled analysis in PANC4

过敏和胰腺癌：PANC4 中的汇总分析

• 批准号: 7880867
• 负责人: SARA H. OLSON
• 金额: $ 9.48万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7880867
• 关键词: Address; Affect; Age; Age of Onset; Body mass index; Case-Control Studies; Characteristics; Confidence Intervals; Confounding Factors (Epidemiology); Data; Data Sources; Disease; Disease Outcome; Early Diagnosis; Environment; Environmental Risk Factor; Epidemiology; Etiology; Future; Gender; Genotype; Geographic Locations; Hay fever; Heterogeneity; Hypersensitivity; Immune system; Individual; International; Lead; Malignant neoplasm of pancreas; Meta-Analysis; Odds Ratio; Patients; Pharmaceutical Preparations; Publishing; Race; Rare Diseases; Research Infrastructure; Risk; Risk Factors; Severities; Site; Smoker; Smoking; Smoking History; Subgroup; Time; abstracting; base; case control; cigarette smoking; gene environment interaction; genome wide association study; immune function; insight; non-smoker; public health relevance; respiratory

DESCRIPTION (provided by applicant): Abstract Pancreatic cancer is a rare and deadly disease. Aside from the association with smoking, little is known about environmental risk factors. Allergies have been consistently found to be associated with reduced risk of pancreatic cancer, with a recent meta-analysis showing a 30% reduction in risk overall and a 45% reduction for respiratory allergies such as hay fever. Individual studies have been too small to reliably investigate whether this association is consistent among subgroups; in addition, the influence of factors related to timing of allergies and indicators of severity is unknown. We propose to conduct a pooled analysis of existing data to address these gaps in our understanding of the association of allergies with risk. The international Pancreatic Cancer Case-Control Consortium (PANC4) includes eight studies with 3000 cases and 8100 controls that will contribute data to this analysis. The specific aims are: 1. to determine the overall association of allergies, and of specific allergies, with risk, and to assess whether this association varies according to subgroups based on age, gender, race, smoking history, body mass index, geographic region and other characteristics. 2: to determine whether factors related to the timing of allergies, such as age at onset, duration, or recency, are related to risk. 3: to evaluate whether indicators of severity of allergies, such as number of allergies and treatment, affect risk. For the eight studies with data on allergies, we will evaluate individual study results for these questions for heterogeneity and compute pooled odds ratios and 95% confidence intervals, with adjustment for study site, age, gender, and race and other potential confounding variables. Several ongoing studies in PANC4 are currently collecting data on allergies, providing the opportunity to confirm and extend our findings in future studies. In addition, results of this analysis will inform future studies of gene-environment interactions when extensive genotyping data become available from the ongoing NCI PANSCAN genome wide association studies. In view of the extremely poor survival from pancreatic cancer (<5% survive 5 years) and the little that is known about risk factors related to the environment or host immune function, it is critical to obtain detailed and precise epidemiologic information on allergies, an established and consistent factor affecting risk which remains poorly understood. PUBLIC HEALTH RELEVANCE: Project Narrative Several studies have found that allergies, particularly hay fever, are associated with reduced risk of pancreatic cancer but very little is known about whether this reduced risk applies to all types of people (such as smokers and non-smokers) or whether it changes with age when allergies began or their severity. By combining existing data from eight studies, we will gain insight into how allergies and the immune system affect risk of pancreatic cancer. In the longer term, this can lead to better means of early detection and possibly new treatment options for this devastating disease.

描述（由申请人提供）： 摘要 胰腺癌是一种罕见且致命的疾病。除了与吸烟的关系外，人们对环境风险因素知之甚少。人们一致发现，过敏与胰腺癌风险降低有关，最近的一项荟萃​​分析显示，总体风险降低 30%，花粉热等呼吸道过敏风险降低 45%。个别研究规模太小，无法可靠地调查这种关联在亚组之间是否一致；此外，与过敏发生时间和严重程度指标相关的因素的影响尚不清楚。我们建议对现有数据进行汇总分析，以解决我们对过敏与风险关联的理解上的差距。国际胰腺癌病例对照联盟 (PANC4) 包括 8 项研究，涉及 3000 例病例和 8100 名对照，将为该分析提供数据。具体目标是： 1. 确定过敏和特定过敏与风险的总体关联，并评估这种关联是否根据基于年龄、性别、种族、吸烟史、体重指数、地理区域和其他特征的亚组而变化。 2：确定与过敏发生时间相关的因素（例如发病年龄、持续时间或新近发生时间）是否与风险相关。 3：评估过敏严重程度指标（例如过敏次数和治疗次数）是否影响风险。对于涉及过敏数据的八项研究，我们将评估这些问题的个体研究结果的异质性，并计算汇总比值比和 95% 置信区间，并对研究地点、年龄、性别、种族和其他潜在混杂变量进行调整。 PANC4 中正在进行的几项研究目前正在收集过敏数据，为在未来的研究中确认和扩展我们的发现提供了机会。此外，当正在进行的 NCI PANSCAN 全基因组关联研究提供大量基因分型数据时，该分析的结果将为未来基因-环境相互作用的研究提供信息。鉴于胰腺癌的生存率极低（<5% 存活 5 年），并且对与环境或宿主免疫功能相关的危险因素知之甚少，获得有关过敏的详细而准确的流行病学信息至关重要，过敏是一种既定且一致的影响风险的因素，但人们对它仍知之甚少。 公共健康相关性：项目叙述 多项研究发现，过敏，尤其是花粉热，与胰腺癌风险降低相关，但人们对这种风险降低是否适用于所有类型的人（例如吸烟者和非吸烟者），或者是否随着过敏开始时的年龄或其严重程度而变化，知之甚少。通过结合八项研究的现有数据，我们将深入了解过敏和免疫系统如何影响胰腺癌的风险。从长远来看，这可以为这种毁灭性疾病提供更好的早期检测手段，并可能提供新的治疗选择。