Serum IgE and Risk of Pancreatic Cancer

血清 IgE 与胰腺癌风险

• 批准号: 8050444
• 负责人: SARA H. OLSON
• 金额: $ 10.14万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-11 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8050444
• 关键词: Affect; Age; Allergens; Biological Markers; Blood; Clinical Research; Colorectal; Data Analyses; Development; Diagnosis; Diagnostic; Disease; Disease Outcome; Disease Pathway; Environmental Risk Factor; Epidemiologic Studies; Epidemiologist; Gender; Hypersensitivity; IgE; Immune; Immune system; Immunotherapy; Individual; Knowledge; Logistic Regressions; Lung; Malignant neoplasm of pancreas; Measures; Odds Ratio; Ovarian; Patient Self-Report; Patients; Physicians; Process; Prospective Studies; Prostate; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial; Race; Resistance; Risk; Risk Estimate; Risk Factors; Role; Screening procedure; Serum; Staging; Testing; abstracting; allergic response; anticancer research; base; case control; cohort; design; experience; food allergen; improved; medical specialties; novel; prospective; respiratory; tumor

DESCRIPTION (provided by applicant): Abstract There is consistent and convincing evidence that self-reported allergies are associated with reduced risk of pancreatic cancer. Very little is understood about this association; a major limitation is the absence of studies of biomarkers of allergic response and their relation to risk. Individuals with allergy have higher levels of serum IgE, both total IgE and allergen-specific IgE. Study of these biomarkers can potentially provide a better indicator of risk than self-report, as well as provide a better understanding of the biologic processes behind this association. The specific aim of this study is to measure pre-diagnostic serum IgE -- total IgE and specific IgE to respiratory allergens and food allergens -- and their associations with risk pancreatic cancer. We hypothesize that higher levels of IgE are associated with reduced risk. We will use a nested case-control design within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Screening Trial. IgE will be measured in 230 pancreatic cancer cases and 460 controls from this cohort, with 2 controls for each case individually matched on age at baseline, gender, race, and date of blood draw. In data analysis, we will investigate the association of each IgE measure with risk of pancreatic cancer, using conditional logistic regression to obtain odds ratios and to adjust for possible confounders. Because of the widespread systemic effects of pancreatic cancer, a prospective design is far stronger than a case-control design in which disease may affect IgE levels. Our study team consists of epidemiologists and a biostatistician who are experienced in pancreatic cancer research, the PLCO cohort, and in IgE measures, and a physician with clinical and research specialties in allergy. While allergies are not a risk factor that can be modified, study of IgE will provide more complete understanding of the biologic underpinnings of the association between allergies and risk. This can help develop a risk profile to identify individuals at increased risk; in addition, understanding of the biologic basis for the observed protective association can suggest novel immune-based therapies for this deadly disease. PUBLIC HEALTH RELEVANCE: Project Narrative Several studies have found that self-reported allergies are associated with reduced risk of pancreatic cancer. In this study, we will investigate whether a biologic marker of allergies, serum IgE, is also related to risk. We will compare IgE for cases and controls in serum that was collected as part of a cohort study several years ago, before cases developed pancreatic cancer. The overall goals are to help define people at higher risk of pancreatic cancer and to better understand the biologic basis of the link between allergies and this disease.

描述（由申请人提供）：摘要有一致和令人信服的证据表明，自我报告的过敏与胰腺癌风险降低有关。对这种关联了解甚少;一个主要的限制是缺乏过敏反应生物标志物及其与风险关系的研究。过敏个体的血清IgE水平较高，包括总IgE和过敏原特异性IgE。对这些生物标志物的研究可能提供比自我报告更好的风险指标，并更好地了解这种关联背后的生物学过程。本研究的具体目的是测量诊断前血清IgE -总IgE和呼吸道过敏原和食物过敏原的特异性IgE-及其与胰腺癌风险的相关性。我们推测，较高水平的IgE与风险降低有关。我们将在前列腺、肺、结直肠和卵巢（PLCO）筛选试验中使用巢式病例对照设计。将在来自该队列的230例胰腺癌病例和460例对照中测量IgE，每例病例有2例对照在基线时的年龄、性别、人种和抽血日期上单独匹配。在数据分析中，我们将研究每种IgE指标与胰腺癌风险的相关性，使用条件logistic回归获得比值比并调整可能的混杂因素。由于胰腺癌的广泛全身效应，前瞻性设计远强于疾病可能影响IgE水平的病例对照设计。我们的研究团队由流行病学家和一名在胰腺癌研究、PLCO队列和IgE测量方面经验丰富的生物统计学家以及一名在过敏方面具有临床和研究专长的医生组成。虽然过敏不是一个可以改变的风险因素，但IgE的研究将提供对过敏和风险之间相关性的生物学基础的更完整的理解。这可以帮助开发风险特征，以识别风险增加的个体;此外，了解所观察到的保护性关联的生物学基础可以为这种致命疾病提供新的基于免疫的疗法。 公共卫生关系：几项研究发现，自我报告的过敏与胰腺癌风险降低有关。在这项研究中，我们将调查过敏的生物标志物血清IgE是否也与风险有关。我们将比较几年前在胰腺癌病例发生前作为队列研究的一部分收集的病例和对照血清中的IgE。总体目标是帮助确定胰腺癌风险较高的人群，并更好地了解过敏与这种疾病之间联系的生物学基础。