ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER

雌激素、饮食、遗传学和子宫内膜癌

• 批准号: 6603120
• 负责人: SARA H. OLSON
• 金额: $ 59.44万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-02 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6603120
• 关键词: aromatase; cancer risk; catechol methyltransferase; clinical research; cytochrome P450; diet; enzyme activity; estrogens; female; genetic susceptibility; hormone regulation /control mechanism; hormone related neoplasm /cancer; human subject; neoplasm /cancer epidemiology; neoplasm /cancer genetics; nutrition related neoplasm /cancer; nutrition related tag; steroid 17alpha monooxygenase; uterus neoplasms; women's health

Risk factors for endometrial cancer, including weight and a high-fat diet, operate through estrogen-related mechanisms. Estrogen promotes growth of transformed cells and there is evidence that some metabolites may have carcinogenic properties. Some of the genes that are important in estrogen metabolism have been found to be polymorphic (CYP17, CYP1 Al, catechol 0-methyltransferase, CYP1 Bi, and CYP19), raising the question of whether genotypes are related to risk. The primary aim of this study is to compare endometrial cancer cases to controls to determine the associations of weight, diet, and genetic susceptibility, independently and jointly, with endometrial cancer. Most endometrial tumors are of endometrioid histology. The rarer serous and clear cell tumors are more aggressive and lethal. Aside from their higher prevalence in older women and in blacks, little is known about risk factors for these tumors, although they appear not to be related to estrogen. The secondary aim is to compare cases with these tumor types to controls to assess risk factors for these poorly-understood tumors. We will conduct a population-based case-control study in six counties in New Jersey. Cases will be women with newly-diagnosed endometrial cancer. Controls will be matched by 5-year age groups and selected by random digit dialing (for those under 65) or from HCFA files (for those aged 65 and over). There will be 600 cases with endometrioid tumors, 200 with serous or clear cell tumors, and 600 controls. Endometrial cancer, already a serious cause of morbidity in the US, is likely to become more common in future years as the population ages and obesity increases. Risk factors such as obesity and poor diets are potentially modifiable. This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors.

子宫内膜癌的危险因素，包括体重和 高脂肪饮食，通过雌激素相关机制起作用。雌激素促进 转化细胞的生长，有证据表明，一些代谢产物可能 具有致癌特性。一些对雌激素很重要的基因 已经发现代谢是多态性的（CYP 17、CYP 1A 1、儿茶酚 0-甲基转移酶，CYP 1Bi和CYP 19），提出了是否 基因型与风险有关。本研究的主要目的是比较 子宫内膜癌病例与对照组比较，以确定体重， 饮食和遗传易感性，独立和联合，与子宫内膜 癌 大多数子宫内膜肿瘤是类子宫内膜样组织。罕见的浆液性和 透明细胞肿瘤更具侵袭性和致命性。除了他们更高的 在老年妇女和黑人中的患病率，对 这些肿瘤，尽管它们似乎与雌激素无关。次级 目的是将这些肿瘤类型的病例与对照组进行比较，以评估风险 这些不太了解的肿瘤的因素。 我们将在纽约州的六个县进行一项基于人群的病例对照研究。 球衣是个什么鬼病例将是新诊断的子宫内膜癌妇女。控制 将按5岁年龄组配对，并以随机数字拨号方式选出（ 65岁以下者）或HCFA档案（65岁及以上者）。会有 600例为类胶质瘤，200例为浆液性或透明细胞瘤， 600个控制器。 子宫内膜癌，在美国已经是一个严重的发病原因， 随着人口老龄化和肥胖， 增大肥胖和不良饮食等风险因素可能 可修改.这项研究将提供有关遗传易感性的数据， 子宫内膜癌与确定的风险因素，以及 关于更致命的浆液性和透明细胞肿瘤的第一个流行病学数据。