Type 1 and Type 2 Endometrial Cancer: Have They Different Risk Factors? A Pooled

1 型和 2 型子宫内膜癌：它们有不同的危险因素吗？

基本信息

批准号：
7779484
负责人：
VERONICA WENDY SETIAWAN
金额：
$ 8.11万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7779484
关键词：
Accounting Address Age Age at Menarche Alcohol consumption Area Behavior Birth Case-Control Studies Characteristics Clear Cell Clinical Combined Oral Contraceptives Development Diabetes Mellitus Diagnosis Disease Endometrial Endometrial Carcinoma Endometrioid Carcinoma Endometrioid Tumor Epidemiologic Studies Epidemiology Estrogens Etiology Exogenous Hormone Therapy Family history of Female Gene Mutation Goals Histologic Hormones Hypertension Individual Knowledge Link Literature Malignant Neoplasms Medical Menopause National Cancer Institute Obesity Oral Contraceptives Outcome Pathogenesis Patients Postmenopause Prevention strategy Reporting Reproductive History Research Risk Factors Sample Size Serous Smoking Somatic Mutation Squamous cell carcinoma Western World Woman base cancer risk case control cohort design improved malignant breast neoplasm mortality outcome forecast parity tumor

项目摘要

DESCRIPTION (provided by applicant): Endometrial cancer is the most common gynecological malignancy in the Western world. Based on differences in pathogenesis and clinical outcomes, endometrial cancer has been divided into two types. Type 1 tumors account for ~90% of endometrial cancers and are classified as endometrioid adenocarcinoma. The remaining Type 2 endometrial cancers are predominantly serous, clear cell, and squamous cell carcinomas. Women diagnosed with type 2 cancers have aggressive disease and poorer survival than those diagnosed with type 1 cancers. Differing somatic mutations implicated in endometrial cancer development have been reported suggesting that the two tumor groups may have distinct etiologies. At present, almost nothing is known about risk factors for Type 2 cancers. Since Type 2 cancers represent only about 10% of endometrial cancers, combining studies is the only way to attain large enough sample sizes to study their risk factors. In this study, we propose a pooled analysis of 24 epidemiologic studies (10 cohort and 14 case-control studies) within the National Cancer Institute's Epidemiology of Endometrial Cancer Consortium (E2C2) to assess the similarities and differences in risk factors for Types 1 and 2 endometrial cancers. Specifically we will examine the associations of menstrual characteristics, reproductive factors, obesity, exogenous hormone use, smoking, alcohol drinking, medical conditions, and family history of endometrial and breast cancer with invasive histologically confirmed Type 1 (n=13,000 cases) and Type 2 (n=1,100) endometrial cancers. The large sample size of the pooled analysis has the power to add unique information to the literature on endometrial cancer risk factors. In particular, this study has the ability to fill the current void in the knowledge about risk factors for the clinically aggressive and lethal Type 2 endometrial cancers.

描述（由申请人提供）：子宫内膜癌是西方世界中最常见的妇科恶性肿瘤。根据发病机理和临床结局的差异，子宫内膜癌已分为两种类型。 1型肿瘤占子宫内膜癌的约90％，并被归类为子宫内膜类腺癌。其余的2型子宫内膜癌主要是浆液性的，透明细胞和鳞状细胞癌。被诊断出患有2型癌症的妇女比诊断为1型癌症的妇女患有侵略性疾病和较差的生存率。据报道，与子宫内膜癌发展有关的不同体细胞突变表明，这两个肿瘤组可能具有不同的病因。目前，关于2型癌症的风险因素几乎一无所知。由于2型癌症仅占子宫内膜癌的10％，因此研究是获得足够大的样本量以研究其危险因素的唯一方法。在这项研究中，我们提出了对国家癌症研究所的子宫内膜癌联盟（E2C2）的流行病学中的24种流行病学研究（10个队列和14例病例对照研究）的汇总分析，以评估1和2类核心型癌症类型的风险因素的相似性和差异。具体而言，我们将研究月经特征，生殖因素，肥胖，外源激素的使用，吸烟，饮酒，饮酒，医疗状况以及子宫内膜和乳腺癌的家族史以及侵入性的组织学确认类型1（n = 13,000例）和2型（n = 1,100例）子宫内膜癌症。合并分析的大样本量有能力为子宫内膜癌危险因素的文献添加独特信息。特别是，这项研究能够在有关临床侵略性和致命2型子宫内膜癌的风险因素的知识中填补当前空隙。