Cancer Epidemiology

项目摘要-癌症流行病学(CE)计划 癌症流行病学(CE)计划的使命是调查癌症风险的决定因素和 通过以相关生物学为基础的流行病学研究取得进展。该计划 还包括开发新的生物统计方法，其中包括复杂的生物测量 从以人口为基础的研究到阐明机制和途径。CE项目由Christopher领导 海曼是一位癌症和遗传流行病学家，他的研究重点是前列腺癌和前列腺癌的遗传风险。 和V.Wendy Setiawan博士，他是癌症风险因素、差异和大数据联系的专家 其研究重点是肝癌、胰腺癌和子宫内膜癌。该计划有25名成员，他们 在CE内部和整个NCCC内部合作，以实现三个特定目标：1)阐明基因的作用 癌症病因和结果的因素，重点是不同种族/民族人群；2)阐明 环境和生活方式因素在癌症病因中的作用；以及3)开发和应用综合治疗方法 癌症环境和遗传流行病学研究中组学数据的统计分析。在此期间 在资金周期中，行政长官成员取得了重大的新发现，包括：1)确定了潜在的致癌物质 电子烟使用者的分子特征；2)晚发个体患胰腺癌的风险增加 非洲裔美国人和拉美裔美国人的糖尿病；3)巨细胞病毒是急性淋巴母细胞白血病的新危险因素 白血病(ALL)和多发性骨髓瘤(MM)；4)证明暴露在空气污染中是致病的危险因素 乳腺癌和脑癌与生存率下降有关；5)多种族多基因的发展 前列腺癌的风险评分正在转化为与TACS计划合作者的临床研究； 6)确定非酒精性脂肪性肝病患病率的差异及其作为危险因素的作用 少数民族人群中的肝癌。通过有效的评估和规划，行政长官建立了新的 计划目标，促进计划内和计划间的协作，并培养有效的初级教师 师徒关系。在目前的资助期内，行政长官调查员发表了607篇论文，其中33%是内部 方案方面，20%是方案间的，76%是多机构的，26%是影响很大的(如果&>9)。 会员持有1,350万美元的癌症相关基金，其中1,220万美元为同行评审，640万美元为NCI基金 (导演)。CE计划对NCCC降低癌症负担的使命做出了至关重要的贡献 通过了解导致癌症差异的病因风险因素，在集水区开展工作。

PROJECT SUMMARY – Cancer Epidemiology (CE) Program The mission of the Cancer Epidemiology (CE) Program is to investigate the determinants of cancer risk and progression through epidemiological studies strongly grounded in the relevant biology. The program also includes the development of novel biostatistical approaches that incorporate complex biological measures from population-based studies to elucidate mechanisms and pathways. The CE program is led by Christopher Haiman ScD, a cancer and genetic epidemiologist whose research is focused on genetic risk of prostate and breast cancer, and V. Wendy Setiawan PhD, an expert on cancer risk factors, disparities, and big data linkages whose research focuses on liver, pancreas and endometrial cancer. The program has 25 members who collaborate within CE and throughout NCCC to accomplish three Specific Aims: 1) Elucidate the role of genetic factors in cancer etiology and outcomes with emphasis on different racial/ethnic populations; 2) Elucidate the role of environmental and lifestyle factors in cancer etiology; and 3) Develop and apply methods for integrative statistical analysis of ‘omics’ data in environmental and genetic epidemiology research in cancer. During this funding cycle, CE members made major novel discoveries including: 1) identification of potentially carcinogenic molecular signatures in e-cigarette users; 2) elevated risk of pancreatic cancer among individuals with late-onset diabetes in African Americans and Latinos; 3) cytomegalovirus as a novel risk factor for acute lymphoblastic leukemia (ALL) and multiple myeloma (MM); 4) demonstration that exposure to air pollution is a risk factor for breast and brain cancer and is associated with decreased survival; 5) development of a multiethnic polygenic risk score for prostate cancer that is being translated to a clinical study with collaborators in the TACS Program; and 6) identification of disparities in prevalence of non-alcoholic fatty liver disease and its role as risk factor for liver cancer among minority populations. Through effective evaluation and planning, CE established new Program goals, catalyzed intra- and inter-programmatic collaborations, and fostered effective junior faculty mentorship. During the current grant period, CE investigators published 607 papers, of which 33% are intra- programmatic, 20% are inter-programmatic, 76% are multi-institutional, and 26% are high impact (IF >9). Members hold $13.5M in cancer-relevant funding, of which $12.2M is peer reviewed and $6.4M is NCI funding (directs). The CE Program contributes critically to NCCC’s mission of decreasing the cancer burden in the catchment area through knowledge of etiologic risk factors underlying cancer disparities.