Type 1 and Type 2 Endometrial Cancer: Have They Different Risk Factors? A Pooled

1 型和 2 型子宫内膜癌：它们有不同的危险因素吗？

• 批准号: 7659200
• 负责人: VERONICA WENDY SETIAWAN
• 金额: $ 8.15万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7659200
• 关键词: Accounting; Address; Age; Age at Menarche; Alcohol consumption; Area; Behavior; Birth; Case-Control Studies; Characteristics; Clear Cell; Clinical; Combined Oral Contraceptives; Development; Diabetes Mellitus; Diagnosis; Disease; Endometrial; Endometrial Carcinoma; Endometrioid Carcinoma; Endometrioid Tumor; Epidemiologic Studies; Epidemiology; Estrogens; Etiology; Exogenous Hormone Therapy; Family history of; Female; Gene Mutation; Goals; Histologic; Hormones; Hypertension; Individual; Knowledge; Link; Literature; Malignant Neoplasms; Medical; Menopause; National Cancer Institute; Obesity; Oral Contraceptives; Outcome; Pathogenesis; Patients; Postmenopause; Prevention strategy; Reporting; Reproductive History; Research; Risk Factors; Sample Size; Serous; Smoking; Somatic Mutation; Squamous cell carcinoma; Western World; Woman; base; cancer risk; case control; cohort; design; improved; malignant breast neoplasm; mortality; outcome forecast; parity; tumor

DESCRIPTION (provided by applicant): Endometrial cancer is the most common gynecological malignancy in the Western world. Based on differences in pathogenesis and clinical outcomes, endometrial cancer has been divided into two types. Type 1 tumors account for ~90% of endometrial cancers and are classified as endometrioid adenocarcinoma. The remaining Type 2 endometrial cancers are predominantly serous, clear cell, and squamous cell carcinomas. Women diagnosed with type 2 cancers have aggressive disease and poorer survival than those diagnosed with type 1 cancers. Differing somatic mutations implicated in endometrial cancer development have been reported suggesting that the two tumor groups may have distinct etiologies. At present, almost nothing is known about risk factors for Type 2 cancers. Since Type 2 cancers represent only about 10% of endometrial cancers, combining studies is the only way to attain large enough sample sizes to study their risk factors. In this study, we propose a pooled analysis of 24 epidemiologic studies (10 cohort and 14 case-control studies) within the National Cancer Institute's Epidemiology of Endometrial Cancer Consortium (E2C2) to assess the similarities and differences in risk factors for Types 1 and 2 endometrial cancers. Specifically we will examine the associations of menstrual characteristics, reproductive factors, obesity, exogenous hormone use, smoking, alcohol drinking, medical conditions, and family history of endometrial and breast cancer with invasive histologically confirmed Type 1 (n=13,000 cases) and Type 2 (n=1,100) endometrial cancers. The large sample size of the pooled analysis has the power to add unique information to the literature on endometrial cancer risk factors. In particular, this study has the ability to fill the current void in the knowledge about risk factors for the clinically aggressive and lethal Type 2 endometrial cancers.

描述（由申请人提供）：子宫内膜癌是西方世界最常见的妇科恶性肿瘤。根据发病机制和临床结果的差异，子宫内膜癌分为两种类型。1型肿瘤占子宫内膜癌的约90%，并被分类为子宫内膜样腺癌。其余2型子宫内膜癌主要是浆液性、透明细胞和鳞状细胞癌。被诊断患有2型癌症的女性比被诊断患有1型癌症的女性具有侵袭性疾病和更差的生存率。不同的体细胞突变涉及子宫内膜癌的发展已被报道，这表明这两个肿瘤组可能有不同的病因。目前，对2型癌症的危险因素几乎一无所知。由于2型癌症仅占子宫内膜癌的10%左右，因此联合研究是获得足够大样本量以研究其风险因素的唯一方法。在这项研究中，我们提出了一个汇总分析24流行病学研究（10个队列和14个病例对照研究）在美国国家癌症研究所的子宫内膜癌流行病学联盟（E2C2），以评估1型和2型子宫内膜癌的危险因素的相似性和差异。具体而言，我们将研究月经特征，生殖因素，肥胖，外源性激素使用，吸烟，饮酒，医疗条件和子宫内膜癌和乳腺癌家族史与浸润性组织学确诊的1型（n= 13，000例）和2型（n= 1，100）子宫内膜癌的相关性。合并分析的大样本量有能力为子宫内膜癌危险因素的文献增加独特的信息。特别是，这项研究有能力填补目前关于临床侵袭性和致死性2型子宫内膜癌风险因素的知识空白。