Trafficking of monocytes and their differentiation to dendritic cells and macrophages in the human liver

人肝脏中单核细胞的贩运及其分化为树突状细胞和巨噬细胞

基本信息

  • 批准号:
    G0700301/1
  • 负责人:
  • 金额:
    $ 44.28万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2007
  • 资助国家:
    英国
  • 起止时间:
    2007 至 无数据
  • 项目状态:
    已结题

项目摘要

Most liver diseases occur as a consequence of uncontrolled inflammation mediated by white blood cells recruited into the liver from the blood. White blood cells enter the liver via channels or sinusoids that are lined by specialised cells called endothelial cells which the white cells must bind to and migrate between before they can enter liver tissue. We propose that this process will a) determine the nature of the cells recruited and b) determine how those cells become activated and thereby the outcome of liver injury. We have developed complex test tube models in which combinations of human liver cells are grown under particular conditions that mimic the environment within the diseased liver sinusoids. We will use these models to investigate how white cells are recruited and how interactions with sinusoidal cells can define the activation status of the cells during their recruitment. Understanding this process will elucidate why in some circumstances white blood cells can promote the repair of the damaged liver whereas in other circumstances they amplify liver injury. We hope to use this information to develop new therapies to manipulate white blood cells in the liver in favour of repair rather than continuing liver damage and thereby to reverse inflammatory liver disease and prevent liver cirrhosis.
大多数肝脏疾病的发生是由从血液中募集到肝脏中的白色血细胞介导的不受控制的炎症的结果。白色血细胞通过通道或窦状隙进入肝脏,通道或窦状隙由称为内皮细胞的特化细胞排列,白色细胞必须结合内皮细胞并在内皮细胞之间迁移,然后才能进入肝脏组织。我们认为,这一过程将a)决定招募的细胞的性质,B)决定这些细胞如何被激活,从而决定肝损伤的结果。我们已经开发了复杂的试管模型,其中人类肝细胞的组合在模拟患病肝窦内环境的特定条件下生长。我们将使用这些模型来研究白色细胞是如何募集的,以及在募集过程中与窦状隙细胞的相互作用如何定义细胞的激活状态。了解这个过程将阐明为什么在某些情况下,白色血细胞可以促进受损肝脏的修复,而在其他情况下,它们会放大肝损伤。我们希望利用这些信息来开发新的治疗方法,以操纵肝脏中的白色血细胞,有利于修复而不是继续肝损伤,从而逆转炎症性肝病并预防肝硬化。

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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David Adams其他文献

Findings in an Unusual MELAS Case Tracking, and Single-Voxel Spectroscopy MR Diffusion Tensor Imaging, Fiber
不寻常的 MELAS 病例追踪和单体素能谱 MR 扩散张量成像、光纤的发现
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    D. Ducreux;G. Nasser;Catherine Lacroix;David Adams;P. Lasjaunias
  • 通讯作者:
    P. Lasjaunias
Patients with a gene encoding a truncated ADP-ribosyl-acceptor hydrolase 3 exhibit a progressive neurodegenerative phenotype
携带编码截短 ADP-核糖基-受体水解酶 3 基因的患者表现出进行性神经退行性表型
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Masato Mashimo;Xiangning Bu;Kazumasa Aoyama;Jiro Kato;Hiroko Ishiwata-Endo;Linda A. Stevens;Atsushi Kasamatsu;Lynne A. Wolfe;Camilo Toro;David Adams;Thomas Markello;William A. Gahl;Joel Moss
  • 通讯作者:
    Joel Moss
Contesting urban monuments: future directions for the controversial monumental landscapes of civic grandeur
有争议的城市纪念碑:有争议的城市宏伟纪念碑景观的未来方向
An Integrated Approach to Developing Technical Communication Skills in Engineering Students
培养工程学生技术沟通技能的综合方法
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    R. Harichandran;D. Adams;David Adams;M. Collura
  • 通讯作者:
    M. Collura
AN ANTIFRAGILE SYSTEM FOR REDUCING PHYSICIAN BURNOUT
减少医生倦怠的抗脆弱系统
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mitchell H. Tsai;Imelda R. Muller;Shelly R. Stelzer;R. Urman;David Adams
  • 通讯作者:
    David Adams

David Adams的其他文献

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{{ truncateString('David Adams', 18)}}的其他基金

The Genomic Atlas of Dermatological Tumours (DERMATLAS)
皮肤肿瘤基因组图谱 (DERMATLAS)
  • 批准号:
    MR/V000292/1
  • 财政年份:
    2021
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Research Grant
Identifying the drivers and vulnerabilities of acral lentiginous melanoma through the study of PDX models from Latin American patients
通过研究拉丁美洲患者的 PDX 模型来确定肢端雀斑样黑色素瘤的驱动因素和脆弱性
  • 批准号:
    MR/S01473X/1
  • 财政年份:
    2018
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Research Grant
A long term resource to maximise the potential of laboratory mouse strains for medical research
最大限度发挥实验室小鼠品系用于医学研究的潜力的长期资源
  • 批准号:
    BB/M000281/1
  • 财政年份:
    2015
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Research Grant
Integrating innovative technologies for genotyping and phenotyping in stratified medicine
在分层医学中整合基因分型和表型分型的创新技术
  • 批准号:
    MR/M009157/1
  • 财政年份:
    2015
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Research Grant
University of Birmingham MRC Proximity to Discovery: Open Innovation Through LocalIntegration
伯明翰大学 MRC 接近发现:通过本地整合进行开放式创新
  • 批准号:
    MC_PC_14123
  • 财政年份:
    2015
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Intramural
Maximising the potential of wild-derived laboratory mouse strains for medical research
最大限度地发挥野生实验室小鼠品系在医学研究中的潜力
  • 批准号:
    MR/L007428/1
  • 财政年份:
    2014
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Research Grant
The iBAC genomic DNA expression library
iBAC 基因组 DNA 表达文库
  • 批准号:
    BB/D012759/1
  • 财政年份:
    2006
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Research Grant
Issues-Directed Introductory Chemistry for Business Students
面向商科学生的问题导向化学入门课程
  • 批准号:
    9150553
  • 财政年份:
    1991
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Standard Grant
Mathematical Sciences: Theory of Capacities
数学科学:能力理论
  • 批准号:
    8702755
  • 财政年份:
    1987
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Standard Grant
Some Questions in Potential Theory and Partial Differential Equations Related to the Lp-Theory of Capacities
势论和偏微分方程中与Lp-容量理论相关的一些问题
  • 批准号:
    8002840
  • 财政年份:
    1980
  • 资助金额:
    $ 44.28万
  • 项目类别:
    Standard Grant

相似国自然基金

TLR2 通过加剧 CD14+Monocytes/Tregs 失调破 坏免疫平衡介导急性胰腺炎重症化的研究
  • 批准号:
    Q24H030030
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    2024
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    0.0 万元
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Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10531750
  • 财政年份:
    2021
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    $ 44.28万
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Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
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  • 批准号:
    10877234
  • 财政年份:
    2021
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Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
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  • 批准号:
    10440492
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    2021
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    $ 44.28万
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Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10663851
  • 财政年份:
    2021
  • 资助金额:
    $ 44.28万
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Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10526150
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    2021
  • 资助金额:
    $ 44.28万
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Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10502298
  • 财政年份:
    2021
  • 资助金额:
    $ 44.28万
  • 项目类别:
Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10616854
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    2021
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Impact of Chronic Alcohol Consumption on the Functional and Epigenetic Landscapes of Monocytes and Their Progenitors
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  • 批准号:
    10252788
  • 财政年份:
    2020
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    $ 44.28万
  • 项目类别:
Analysis of Inducers of Transformation From Monocytes to Macrophages and Their Application for vascular Protection Therapy
单核细胞向巨噬细胞转化诱导剂分析及其在血管保护治疗中的应用
  • 批准号:
    15590718
  • 财政年份:
    2003
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    $ 44.28万
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    Grant-in-Aid for Scientific Research (C)
Functional priming of inflammatory cells and modulation of their apoptosis: significance of these events in children's diseases
炎症细胞的功能启动及其细胞凋亡的调节:这些事件在儿童疾病中的意义
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    12670738
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    2000
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    $ 44.28万
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    Grant-in-Aid for Scientific Research (C)
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