Application for a small exchange award to fund a 6-month sabbatical for Professor Wynick at the Neurology & GI CEDD, GSK

申请小额交换奖励，资助 Wynick 教授在神经科的 6 个月休假

• 批准号: G0700649/1
• 负责人: David Wynick
• 金额: $ 7.46万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700649%2F1
• 关键词: Application; small; exchange; award; fund

Most pain killers never make it to market because of side effects and/or lack of effectiveness. In the 6 months I will spend at GSK, we will focus on the reasons for those failures and focus on (a) the most appropriate use of the latest cutting-edge in-vivo and in-vitro technologies to validate new pain targets and (b) new and improved models of neuropathic and spontaneous pain that are more relevant to the human diseases associated with chronic neuropathic pain eg multiple sclerosis and Type II diabetes mellitus.

由于副作用和/或缺乏有效性，大多数止痛药从未上市。在我将在葛兰素史克工作的6个月里，我们将重点关注这些失败的原因，并关注(A)最新尖端体内和体外技术的最适当使用，以验证新的止痛靶点，以及(B)与人类慢性神经性疼痛相关疾病(如多发性硬化症和II型糖尿病)更相关的神经病理性和自发性疼痛的新模型和改进模型。