Imaging Dopamine Mediated Neurovascular Coupling
Imaging Dopamine Mediated Neurovascular Coupling
批准号:
7908867
负责人:
Bruce G Jenkins
金额:
$37.69万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-09-20 至 2012-02-29
关键词:
AbstinenceAgonistAmphetaminesAnimalsAttenuatedAutoradiographyBehaviorBindingBiological AssayBlood VolumeBrain regionCerebrumCocaineCompanionsContrast MediaCouplingDataDetectionDopamineDopamine AgonistsDopamine D2 ReceptorDopamine ReceptorDopaminergic AgentsDropsDrug abuseFamilyFundingGleanGoalsImageIndividualLeadLigandsMagnetic Resonance ImagingMagnetismMapsMeasurementMeasuresMediatingMetabolicMethodsMicrodialysisModelingMusNeuronsNoiseOxidopaminePharmaceutical PreparationsPositron-Emission TomographyPredispositionRacloprideRattusRelative (related person)Research PersonnelRoleSelf AdministrationSelf-AdministeredSignal TransductionStagingStimulusSubstance abuse problemSynapsesTechniquesTestingTimeWithdrawalbasecocaine exposuredensitydrug of abusehemodynamicsimprovedmRNA Expressionmagnetic fieldnovelprogramsputamenreceptorreceptor densityreceptor functionresponsereuptaketool
中文摘要
描述(由申请人提供):本次竞争性更新旨在继续为我们的研究提供资金,以了解与多巴胺能药物相关的MRI信号变化背后的机制。在本申请中,我们将寻求确定与各种多巴胺受体亚型的刺激相关的信号变化的组分。此外,我们将这些变化与多巴胺释放的变化相关联,这些变化是使用微透析技术测定的,并使用正电子发射断层扫描(PET)和放射自显影技术定量测量多巴胺受体。此外,我们将探讨阻断不同多巴胺受体亚型对滥用药物(如可卡因和安非他明)引起的血流动力学变化的影响。然后,我们将分析这些受体亚型如何在两种不同的多巴胺能调节模型中变化。首先,我们将研究可卡因自我管理后随之而来的变化。因此,我们将对多巴胺受体亚型的变化进行纵向测量,作为可卡因暴露和戒断的函数。将使用真实的时间PCR、PET成像、MRI和微透析来分析这些变化。我们还将使用6-OHDA多巴胺模型进行伴随研究,以检查多巴胺能耗竭对多巴胺受体亚型的影响,以及它们对可卡因和安非他明等药物引起的信号变化的影响。最后,我们将提高我们的定量能力,使用更高的对比度噪声技术获取数据,以及使用多巴胺能释放和再摄取曲线模拟信号变化。
英文摘要
DESCRIPTION (provided by applicant): This competing renewal seeks to continue funding for our studies to understand the mechanisms behind MRI signal changes associated with dopaminergic drugs. In this application we will seek to determine the components of the signal changes that are related to stimulation of the various dopamine receptor sub-types. In addition, we will correlate these changes with changes that are noted in dopamine release as determined using microdialysis techniques and with quantitative measurements of dopamine receptors using positron emission tomography (PET) and autoradiographic techniques. Further, we will probe the effects that blocking different dopamine receptor sub-types will have on the hemodynamic changes elicited by drugs of abuse such as cocaine and amphetamines. Then we will assay how these receptor sub-types change in two different models of dopaminergic modulation. In the first, we will examine changes that are attendant upon cocaine self-administration. Thus, we will perform longitudinal measurements of changes in dopamine receptor sub- types as a function of cocaine exposure and withdrawal. These changes will be assayed using both real time PCR, PET imaging, MRI and microdialysis. We will also perform companion studies using the 6-OHDA dopamine model to examine the effects of dopaminergic depletion on dopamine receptor subtypes, and their effects on signal changes evoked by drugs such as cocaine and amphetamine. Finally, we will improve both our quantitative ability to acquire the data using higher contrast to noise techniques as well as model the signal changes using dopaminergic release and reuptake curves.
期刊论文(11)
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DOI:
10.1038/npp.2011.1
发表时间:
2011-05
期刊:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1002/syn.20659
发表时间:
2009-09
期刊:
SYNAPSE
影响因子:
2.3
作者:
[Ren, Jiaqian, Xu, Haibo, Choi, Ji-Kyung, Jenkins, Bruce G., Chen, Y. Iris]
通讯作者:
Chen, Y. Iris
DOI:
10.1016/j.neuroimage.2012.03.075
发表时间:
2012-08-15
期刊:
NeuroImage
影响因子:
5.7
作者:
[Jenkins BG]
通讯作者:
Jenkins BG
DOI:
10.1016/j.neuroimage.2018.02.059
发表时间:
2018-07-01
期刊:
NeuroImage
影响因子:
5.7
作者:
[Choi JK, Lim G, Chen YI, Jenkins BG]
通讯作者:
Jenkins BG
Longitudinal monitoring of motor neuron circuitry in FALS rats using in-vivo phMRI.
使用体内 phMRI 纵向监测 FALS 大鼠的运动神经元回路。
DOI:
10.1097/wnr.0b013e328330eb9e
发表时间:
2010
期刊:
Neuroreport
影响因子:
1.7
作者:
[Choi,Ji-Kyung, Dedeoglu,Alpaslan, Jenkins,BruceG]
通讯作者:
Jenkins,BruceG
Combined MRI/PET Imager for Simultaneous Acquisition of PET/MRI Data
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批准号:7125804
-
项目类别:
-
资助金额:$200.0万
-
财政年份:2007
-
负责人:Bruce G Jenkins
-
依托单位:
Imaging Dopamine-Mediated Neuro-Vascular Coupling
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批准号:6549321
-
项目类别:
-
资助金额:$41.49万
-
财政年份:2002
-
负责人:Bruce G Jenkins
-
依托单位:
Imaging Dopamine-Mediated Neuro-Vascular Coupling
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批准号:6659710
-
项目类别:
-
资助金额:$43.14万
-
财政年份:2002
-
负责人:Bruce G Jenkins
-
依托单位:
Imaging Dopamine-Mediated Neuro-Vascular Coupling
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批准号:6761969
-
项目类别:
-
资助金额:$43.14万
-
财政年份:2002
-
负责人:Bruce G Jenkins
-
依托单位:
Imaging Dopamine Mediated Neurovascular Coupling
-
批准号:7675241
-
项目类别:
-
资助金额:$37.74万
-
财政年份:2002
-
负责人:Bruce G Jenkins
-
依托单位:
Imaging Dopamine-Mediated Neuro-Vascular Coupling
-
批准号:6926287
-
项目类别:
-
资助金额:$43.14万
-
财政年份:2002
-
负责人:Bruce G Jenkins
-
依托单位:
Imaging Dopamine Mediated Neurovascular Coupling
-
批准号:7495028
-
项目类别:
-
资助金额:$37.74万
-
财政年份:2002
-
负责人:Bruce G Jenkins
-
依托单位:
Imaging Dopamine Mediated Neurovascular Coupling
-
批准号:7320302
-
项目类别:
-
资助金额:$36.48万
-
财政年份:2002
-
负责人:Bruce G Jenkins
-
依托单位:
Synaptic Mechanisms of Dopaminergically Mediated MRI Signal Changes
-
批准号:6358943
-
项目类别:
-
资助金额:$16.18万
-
财政年份:2000
-
负责人:Bruce G Jenkins
-
依托单位:
NMR STUDIES OF TRANSGENIC MOUSE MODELS OF HUNTINGTONS DISEASE & ALS
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批准号:6355127
-
项目类别:
-
资助金额:$2.03万
-
财政年份:2000
-
负责人:Bruce G Jenkins
-
依托单位:
NMR STUDIES OF TRANSGENIC MOUSE MODELS OF HUNTINGTONS DISEASE & ALS
-
批准号:6118670
-
项目类别:
-
资助金额:$2.03万
-
财政年份:1999
-
负责人:Bruce G Jenkins
-
依托单位:
Synaptic Mechanisms of Dopaminergically Mediated MRI Signal Changes
-
批准号:6227719
-
项目类别:
-
资助金额:$16.18万
-
财政年份:1994
-
负责人:Bruce G Jenkins
-
依托单位:
国内基金
海外基金
Agonist-GPR119-Gs复合物的结构生物学研究
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批准号:32000851
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项目类别:青年科学基金项目
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资助金额:24.0万元
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批准年份:2020
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负责人:乔安娜
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依托单位: