Ovarian anti-Mullerian hormone: what does it do in the normal ovary and why is it so high in polycystic ovary syndrome?

卵巢抗苗勒氏管激素：它在正常卵巢中起什么作用？为什么它在多囊卵巢综合征中如此高？

• 批准号: G0700916/1
• 负责人: Helen Mason
• 金额: $ 39.51万
• 依托单位: St George's, University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700916%2F1
• 关键词: Ovarian; anti; Mullerian; hormone; what

In the womb, boy babies develop part of their reproductive system because of the actions of a hormone called anti-Mullerian hormone (AMH). Interestingly, this hormone has now been shown to play a part in adult women in that it is involved in the working of the ovary. In the ovary each month an egg is grown and released. We have found that only those eggs which have got rid of AMH manage to grow. This is important because we have also found that the levels of this hormone are very high in a common condition which causes infertility. We now need to find out why the levels are high in these women and what exactly AMH does in the ovary. We hope that this will allow us to help these women to have better fertility in the future.

在子宫里，由于一种称为抗苗勒管激素（AMH）的激素的作用，男婴的生殖系统部分发育。有趣的是，这种激素现在已经被证明在成年女性中发挥作用，因为它参与卵巢的工作。在卵巢中，每个月都有一个卵子生长并释放出来。我们发现，只有那些已经摆脱AMH的卵子才能生长。这很重要，因为我们还发现，这种激素的水平在导致不孕的常见情况下非常高。我们现在需要找出为什么这些妇女的水平很高，以及AMH在卵巢中的确切作用。我们希望这将使我们能够帮助这些妇女在未来有更好的生育能力。