A population-based study of the effect of infertility and its treatment on child health and development

一项基于人群的不孕症及其治疗对儿童健康和发育影响的研究

• 批准号: G0701009/1
• 负责人: Maria Quigley
• 金额: $ 31.79万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701009%2F1
• 关键词: population; based; study; effect; infertility

Infertility affects about one in seven couples in the UK. The development of infertility treatments such as IVF has helped many couples to conceive. As well as looking at short-term success rates such as becoming pregnant and giving birth, it is important to assess the safety of infertility treatments, including any possible longer term effects on the child.Our study will look at the effects of infertility and its treatment on a range of child health and development outcomes. We will use data from a national study of over 19,000 babies born in the UK. Parents of these children were interviewed when the children were aged 9 months, 3 years and 5 years. The parents were asked about many things including the child?s health and development. The interviewers performed standard assessments on the children which assessed how well they were developing for their age.We will compare three groups of children: those who resulted from ?a usual time to conception? (those whose parents did not have difficulties conceiving); those who resulted from ?a prolonged time to conception? (those whose parents had difficulties conceiving but managed to conceive without treatment); and those who were conceived following infertility treatment. We will assess whether the health and development in these three groups of children varies.The team for this study has the experience necessary to ensure that this research will be high quality and relevant to those who are having or considering infertility treatment. The results will be published in medical journals. We will liaise with the Human Fertilisation and Embryology Authority and Infertility Network UK to ensure that our findings are reported to those who will find them useful.

在英国，大约七分之一的夫妇患有不孕症。诸如体外受精等不孕症治疗的发展帮助了许多夫妇怀孕。除了观察怀孕和分娩等短期成功率外，评估不孕症治疗的安全性也很重要，包括对孩子可能产生的长期影响。我们的研究将着眼于不孕症及其治疗对一系列儿童健康和发展结果的影响。我们将使用一项针对英国出生的19,000多名婴儿的全国性研究的数据。这些孩子的父母在孩子9个月，3岁和5岁时接受了采访。父母被问及很多事情，包括孩子？健康与发展。采访者对孩子们进行了标准的评估，以评估他们在他们的年龄中发展得如何。我们将比较三组儿童：由？受孕的正常时间？（父母没有怀孕困难的人）；那些源于？长时间受孕？（父母怀孕有困难但未经治疗成功怀孕的人）；以及那些在不孕症治疗后怀孕的人。我们将评估这三组儿童的健康和发展是否有所不同。这项研究的团队拥有必要的经验，以确保这项研究将是高质量的，并与那些正在接受或考虑接受不孕症治疗的人相关。研究结果将发表在医学杂志上。我们将与人类受精和胚胎学管理局以及英国不孕症网络保持联系，以确保我们的发现报告给那些认为它们有用的人。