A Novel In-Axis Beam-Splitting Common-Path Michelson Interferometer for Endoscopi

一种新型内窥镜同轴分束共光路迈克尔逊干涉仪

• 批准号: 7881870
• 负责人: Hai Xiao
• 金额: $ 22.73万
• 依托单位: MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7881870
• 关键词: Academic Research Enhancement Awards; Achievement; Biological; Biomedical Engineering; Biomedical Research; Body cavities; Catheters; Collaborations; Detection; Development; Devices; Disease; Early Diagnosis; Education; Environment; Evaluation; Exploratory/Developmental Grant; Fiber Optics; Foundations; Future; Goals; Guidelines; Hand; Heart; Human; Image; Imaging Techniques; Instruction; Length; Light; Malignant - descriptor; Malignant Neoplasms; Mechanics; Missouri; Optical Biopsy; Optical Coherence Tomography; Optics; Organ; Penetration; Performance; Phase; Principal Investigator; Recruitment Activity; Research; Resolution; Sampling; Scanning; Science; Solid; Source; Staging; Structure; Students; System; Technology; Test Result; Testing; Tissues; Training; Universities; Work; arm; base; body cavity; clinical application; design; flexibility; graduate student; image guided intervention; imaging modality; in vivo; innovation; millimeter; models and simulation; next generation; novel; optical fiber; optical imaging; photonics; professor; programs; prototype; public health relevance; sensor; simulation; success

DESCRIPTION (provided by applicant): As a noninvasive imaging modality, optical coherence tomography (OCT) has been proven useful for early diagnosis of malignant cancers as well as image-guided interventions. However, OCT is only effective for subsurface imaging due to the limited penetration depth of light. To overcome this limitation, endoscopic OCT has been developed in which a flexible OCT probe is inserted into a body cavity for imaging internal organs. Current endoscopic probes, implemented based on the fiber optic Michelson interferometer (FOMI), fiber optic Mach-Zehnder interferometer (FOMZI), or fiber optic Fizeau interferometer (FOFI), have a number of drawbacks such as poor phase stability, downlead sensitivity and non-extendable probe length for FOMI and FOMZI, limited working distance and reduced sensitivity for MOFI. These drawbacks have hindered the clinical applications of endoscopic OCT. The objective of this AREA application is to develop a new common-path OCT (CP-OCT) probe with extended and adjustable working distance, high phase stability, high spatial resolution, and negligible downlead sensitivity for in vivo endoscopic optical biopsy. The key innovation in this program is a novel ultracompact, in-axis beam-splitting, common-path Michelson interferometer that effectively circumvents the polarization and dispersion mismatch issues to achieve a high phase stability and extendable probe length. Two specific aims are designed in this program, including: 1) Development of a novel ultracompact CP- OCT endoscopic probe, and 2) Evaluation and demonstration of the developed CP-OCT probe using a swept source OCT (SSOCT) system. The optical and mechanical designs of the new OCT probe will be performed and the design results will be used to guide the implementation of a lab-style prototype. A bench-top SSOCT system will be implemented for performance evaluation and technology demonstration of the developed OCT probe. It is anticipated that this work will lay a solid foundation to expand our existing research scope and make contributions to the Nation's biomedical research and education. Upon successful achievement of the specific aims, a subsequent phase of research (through R15 or R21 mechanism) will be pursued. An important objective/task embedded in this AREA proposal is to strengthen the health-related research environment at the Missouri University of Science and Technology (MST). This AREA research topic has been carefully chosen to leverage our existing strengths in optical fiber interferometers, photonic micro structures, devices and sensors. Undergraduate and graduate students will receive direct trainings in health-related research. In addition, some of the research results will be converted to class instruction materials to expose a large student body at MST to health-related research topics. PHS 398/2590 (Rev. 11/07) Page Continuation Format Page PUBLIC HEALTH RELEVANCE: The main objective of this proposal is to develop a novel common-path OCT probe with extended and adaptable working distance, high phase stability, high spatial resolution, and negligible downlead sensitivity for in vivo endoscopic optical biopsy. The new endoscopic OCT probe has a great potential for early diagnosis of malignant cancers as well as image-guided interventions in human internal organs.

描述（由申请人提供）：作为非侵入性成像方式，光学相干断层扫描（OCT）已被证明可用于早期诊断恶性癌和图像引导的干预措施。但是，由于光穿透深度有限，OCT仅对地下成像有效。为了克服这一局限性，已经开发出内窥镜OCT，其中将柔性OCT探针插入体腔中以成像内部器官。基于光纤的米歇尔森干涉仪（FOMI），光纤手机齐汉德尔干涉仪（FOMZI）或光纤纤维纤维Fizeau fizeau干涉仪（FOFI）实施的当前内窥镜探针具有许多较差的相位稳定性，对敏感性和非远距离远距离的距离和fomi的距离有限差异，并具有多种差距。这些缺点阻碍了内窥镜OCT的临床应用。 该区域应用的目的是开发一个新的常见路径OCT（CP-OCT）探针，具有延长且可调节的工作距离，高相稳定性，高空间分辨率以及对体内内窥镜光学活检的敏感性可忽略不计。该程序中的关键创新是一种新型的超跨，轴射梁拆分，常见的米歇尔森干涉仪，可有效绕过极化和分散不匹配的问题，以达到高相位稳定性和可扩展的探头长度。 该程序设计了两个具体的目标，包括：1）开发新型的超轨迹CP- OCT内窥镜探针，以及2）使用扫描源OCT（SSOCT）系统对开发的CP-OCT探针进行评估和演示。将执行新的OCT探针的光学和机械设计，并将使用设计结果来指导实施实验室风格的原型。将实施一个台式SSOCT系统，用于开发的OCT探针的性能评估和技术演示。预计这项工作将为扩大我们现有的研究范围并为国家的生物医学研究和教育做出贡献奠定坚实的基础。在成功实现特定目标后，将追求随后的研究阶段（通过R15或R21机制）。 该领域提案中嵌入的重要目标/任务是加强密苏里科学技术大学（MST）的与健康相关的研究环境。该区域研究主题已被仔细选择，以利用我们在光纤干涉仪，光子微型结构，设备和传感器中的现有优势。本科生和研究生将接受与健康相关研究的直接培训。此外，某些研究结果将转换为课堂教学材料，以将大型学生团体在MST中暴露于与健康相关的研究主题。 PHS 398/2590（Rev. 11/07）页面延续格式页面 公共卫生相关性：该提案的主要目的是开发一种具有扩展和适应能力的工作距离，高相位稳定性，高空间分辨率和对体内内窥镜光学活检的敏感性可忽略的敏感性的新型共同路径探针。新的内窥镜OCT探针具有早期诊断恶性肿瘤以及人类内部器官的图像引导干预措施的巨大潜力。