Advanced Fabrication and Testing Core

先进的制造和测试核心

• 批准号: 10244917
• 负责人: Hai Xiao
• 金额: $ 29.98万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244917
• 关键词: 3-Dimensional; 3D Print; Animals; Area; Atomic Force Microscopy; Biological; Biomedical Engineering; Biomedical Research; Cells; Centers of Research Excellence; Ceramics; Clinical; Computer Models; Consultations; Consumption; Devices; Diagnosis; Electron Microscopy; Engineering; Environment; Equipment; Funding; Generations; Goals; Hand; Harvest; Health; Human; Image; Imaging Device; In Situ; Intervention; Laboratories; Laboratory Research; Lasers; Location; Measurement; Mechanics; Mentors; Metals; Microscope; Mind; Modeling; Musculoskeletal; Musculoskeletal Diseases; Optics; Output; Patients; Printing; Program Sustainability; Property; Research; Research Personnel; Resources; Role; Services; Solid; South Carolina; Spectroscopy, Fourier Transform Infrared; Strategic Planning; System; Technology; Testing; Therapeutic; Time; Tissues; Training; Translating; Translational Research; Translations; Universities; Validation; X ray diffraction analysis; activating transcription factor; base; cost; data acquisition; design; engineering design; experience; human model; improved; in vivo; innovation; instrument; instrumentation; member; microscopic imaging; multidisciplinary; nano; nanolithography; novel; operation; process optimization; professor; prototype; sensor; signal processing; success; three-dimensional modeling; tool; virtual human

SUMMARY As an integral part of the SC-TRIMH, the Advanced Fabrication and Testing (AFT) Core harvests and consolidates the unique engineering strengths and capabilities at Clemson University to support the junior investigator projects, and expedite the translation of their innovations to patient specific diagnosis and treatments of musculoskeletal diseases at the cell/molecule, tissue and body levels. The overall goal of the AFT Core is to establish the centralized resources of 3D model based designs, rapid prototyping and advanced testing for the TRIMH investigators to enable and perform their translational musculoskeletal research. The specific aims include: Aim 1 - Via the Design and Rapid prototyping role of the AFT, enable TRIMH researchers to quickly design and establish a simulated musculoskeletal component, system or environment that is a physical and biological replica of a human model to validate the virtual human trial models. Core services toward this end include mechanical design, CAD drawing, process optimization and rapid 3D printing (nano, micro and macro fabrications) of the designed parts. Aim 2 - Via the Sensor, Instrumentation and testing role of the AFT, allow the investigators to design, fabricate and install sensors onto the physical/biological replica for in situ measurement of various parameters and validation of the models. Core services to assist these outputs include sensor design, fabrication and installation, optical and electrical design, instrumentation, data acquisition, signal processing, and advanced testing/validation. Aim 3 - Promote AFT as a leading centralized, sustainable biomedical engineering resource, especially for musculoskeletal related research at Clemson University, South Carolina, and beyond. The AFT Core will be led by a multidisciplinary team consisting two engineering (mechanical and electrical) professors with the combined expertise in mechanical/optical/electrical designs, advanced manufacturing, rapid prototyping, sensors, instrumentation, imaging, and advanced testing. The COBRE fund will support experienced staff members to operate/maintain the consolidated facilities, to train/mentor TRIMH investigators to translate their innovations into clinical successes, and to facilitate the transition of the AFT Core to a competitive and self-sustained program.

概括 作为SC-Trimh的组成部分，高级制造和测试（AFT）核心收获和 巩固克莱姆森大学独特的工程优势和能力，以支持大三 调查员项目，并加快将其创新转化为患者特定诊断和治疗 细胞/分子，组织和身体水平上的肌肉骨骼疾病。船尾核心的总体目标是 建立基于3D模型设计的集中资源，快速原型制作和高级测试 TRIMH研究人员可以启用并进行翻译肌肉骨骼研究。具体目标 包括：AIM 1-通过AFT的设计和快速原型制作作用，使Trimh研究人员能够快速 设计并建立一个模拟的肌肉骨骼组件，系统或环境，该组件是物理和环境 人类模型的生物复制品验证虚拟人类试验模型。核心服务 包括机械设计，CAD图，过程优化和快速3D打印（Nano，Micro和Macro） 设计零件的制造）。 AIM 2-通过传感器，仪器和测试作用，允许 调查人员设计，制造和安装传感器在原位的物理/生物复制品上 测量各种参数和模型验证。协助这些输出的核心服务包括 传感器设计，制造和安装，光学和电气设计，仪器，数据采集，信号 处理和高级测试/验证。目标3-促进船尾作为领先的集中式，可持续 生物医学工程资源，尤其是在南部克莱姆森大学的肌肉骨骼相关研究 卡罗来纳州及以后。船尾核心将由一个跨学科团队领导，其中两个工程 （机械和电气）具有机械/光学/电气设计的联合专业知识的教授， 高级制造，快速原型制造，传感器，仪器，成像和高级测试。这 COBRE基金将支持经验丰富的员工运营/维护合并的设施， 培训/导师Trimh调查人员将其创新转化为临床成功，并促进 将后核过渡到竞争性和自我维持的计划。