Advanced Fabrication and Testing Core

先进的制造和测试核心

• 批准号: 10244917
• 负责人: Hai Xiao
• 金额: $ 29.98万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244917
• 关键词: 3-Dimensional; 3D Print; Animals; Area; Atomic Force Microscopy; Biological; Biomedical Engineering; Biomedical Research; Cells; Centers of Research Excellence; Ceramics; Clinical; Computer Models; Consultations; Consumption; Devices; Diagnosis; Electron Microscopy; Engineering; Environment; Equipment; Funding; Generations; Goals; Hand; Harvest; Health; Human; Image; Imaging Device; In Situ; Intervention; Laboratories; Laboratory Research; Lasers; Location; Measurement; Mechanics; Mentors; Metals; Microscope; Mind; Modeling; Musculoskeletal; Musculoskeletal Diseases; Optics; Output; Patients; Printing; Program Sustainability; Property; Research; Research Personnel; Resources; Role; Services; Solid; South Carolina; Spectroscopy, Fourier Transform Infrared; Strategic Planning; System; Technology; Testing; Therapeutic; Time; Tissues; Training; Translating; Translational Research; Translations; Universities; Validation; X ray diffraction analysis; activating transcription factor; base; cost; data acquisition; design; engineering design; experience; human model; improved; in vivo; innovation; instrument; instrumentation; member; microscopic imaging; multidisciplinary; nano; nanolithography; novel; operation; process optimization; professor; prototype; sensor; signal processing; success; three-dimensional modeling; tool; virtual human

SUMMARY As an integral part of the SC-TRIMH, the Advanced Fabrication and Testing (AFT) Core harvests and consolidates the unique engineering strengths and capabilities at Clemson University to support the junior investigator projects, and expedite the translation of their innovations to patient specific diagnosis and treatments of musculoskeletal diseases at the cell/molecule, tissue and body levels. The overall goal of the AFT Core is to establish the centralized resources of 3D model based designs, rapid prototyping and advanced testing for the TRIMH investigators to enable and perform their translational musculoskeletal research. The specific aims include: Aim 1 - Via the Design and Rapid prototyping role of the AFT, enable TRIMH researchers to quickly design and establish a simulated musculoskeletal component, system or environment that is a physical and biological replica of a human model to validate the virtual human trial models. Core services toward this end include mechanical design, CAD drawing, process optimization and rapid 3D printing (nano, micro and macro fabrications) of the designed parts. Aim 2 - Via the Sensor, Instrumentation and testing role of the AFT, allow the investigators to design, fabricate and install sensors onto the physical/biological replica for in situ measurement of various parameters and validation of the models. Core services to assist these outputs include sensor design, fabrication and installation, optical and electrical design, instrumentation, data acquisition, signal processing, and advanced testing/validation. Aim 3 - Promote AFT as a leading centralized, sustainable biomedical engineering resource, especially for musculoskeletal related research at Clemson University, South Carolina, and beyond. The AFT Core will be led by a multidisciplinary team consisting two engineering (mechanical and electrical) professors with the combined expertise in mechanical/optical/electrical designs, advanced manufacturing, rapid prototyping, sensors, instrumentation, imaging, and advanced testing. The COBRE fund will support experienced staff members to operate/maintain the consolidated facilities, to train/mentor TRIMH investigators to translate their innovations into clinical successes, and to facilitate the transition of the AFT Core to a competitive and self-sustained program.

摘要 作为SC-TRIMH的一个组成部分，先进制造和测试(AFT)核心收获和 巩固克莱姆森大学独特的工程优势和能力，以支持低年级学生 研究人员项目，并加快将其创新转化为针对患者的诊断和治疗 在细胞/分子、组织和身体层面上对肌肉骨骼疾病的研究。AFT核心的总体目标是 建立基于3D模型的设计、快速原型和高级测试的集中资源 TRIMH研究人员启用并执行他们的转译肌肉骨骼研究。具体目标 包括：目标1-通过AFT的设计和快速成型作用，使TRIMH研究人员能够快速 设计和建立模拟肌肉骨骼组件、系统或环境，该组件、系统或环境是物理和 人体模型的生物复制品，以验证虚拟人体试验模型。实现这一目标的核心服务 包括机械设计、CAD绘图、工艺优化和快速3D打印(纳米、微观和宏观 制造)设计的部件。目标2-通过AFT的传感器、仪器和测试角色，允许 研究人员设计、制造传感器并将传感器安装到物理/生物复制品上以供现场使用 各种参数的测量和模型的验证。协助这些产出的核心服务包括 传感器设计、制造和安装、光学和电气设计、仪器仪表、数据采集、信号 处理和高级测试/验证。目标3-推动AFT成为领先的集中式、可持续的 生物医学工程资源，特别是在南方克莱姆森大学的肌肉骨骼相关研究 卡罗莱纳州，以及更远的地方。AFT核心将由一个由两名工程人员组成的多学科团队领导 (机械和电气)教授，具有机械/光学/电气设计的综合专业知识， 先进制造、快速成型、传感器、仪器仪表、成像和先进测试。这个 Cobre基金将支持有经验的工作人员运营/维护综合设施，以 培训/指导TRIMH研究人员将他们的创新转化为临床成功，并促进 将AFT核心项目转变为具有竞争力和自给自足的项目。