Advanced Fabrication and Testing Core (AFT)

先进制造和测试核心 (AFT)

• 批准号: 10714165
• 负责人: Hai Xiao
• 金额: $ 28.96万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714165
• 关键词: 3-Dimensional; 3D Print; Applications Grants; Area; Automation; Award; Biocompatible Materials; Biological; Biomedical Engineering; Centers of Research Excellence; Ceramics; Client; Clinical; Complex; Diagnosis; Discipline; Engineering; Equipment; Event; Funding; Generations; Glass; Goals; Grant; Hand; Harvest; Health; Image; Imaging technology; In Situ; Industrialization; Lasers; Light; Measurement; Mechanics; Mentors; Metals; Mind; Molecular; Musculoskeletal; Musculoskeletal Diseases; Optics; Patients; Phase; Physical environment; Pilot Projects; Procedures; Process; Program Sustainability; Publications; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Secure; Services; Source; South Carolina; Standardization; Strategic Planning; System; Technology; Testing; Time; Tissues; Training; Training Activity; Translating; Translations; United States National Institutes of Health; Universities; Validation; Work; data acquisition; design; engineering design; experience; fabrication; graphical user interface; human model; improved; innovation; instrument; instrumentation; manufacture; manufacturing systems; meetings; member; models and simulation; multidisciplinary; operation; programs; prototype; second harmonic; sensor; signal processing; success; technological innovation; tool; virtual human

SUMMARY The Advanced Fabrication and Testing (AFT) Core is the enabling technological engine of the SC-TRIMH. It harvests the unique engineering strengths and capabilities at Clemson University to support the research projects and expedite the translation of their innovations to patient-specific diagnosis and treatments of musculoskeletal diseases at the molecular, cellular, tissue, and body levels. In Phase I, the AFT Core expanded to now cover over 4,400 sq ft when it consolidated all its services in a new building in order to provide more centralized services for electrical, mechanical, optical, and material designs, rapid prototyping, sensors and instrumentation, and advanced testing for the TRIMH investigators. The core also expanded its instrumentation (e.g. integrated additive and subtractive manufacturing, plus femtosecond laser for ultrafast micromachining) via awards from DOE and a TRIMH supplement. During this time the AFT Core provided services to all 8 TRIMH Research Project Leaders (RPL), 8 other TRIMH Pilot Project Leaders, and 12 Clemson PIs. Seven other PIs from the state of South Carolina (SC) and 6 others outside SC used this core; along with three industrial clients. This core is especially important to those who do not have primary expertise in the engineering disciplines, as we have both turnkey services and tailored “hand holding”/mentoring. The AFT core in Phase I has supported nearly 50 PIs, contributed to 30 grant applications, and generated more than 30 publications. In Phase II, we will be supporting the research projects of all 4 RPLs while we continue to expand and sustain the engineering capabilities and strive to build the AFT Core into a leading biomedical engineering resource, especially for musculoskeletal related research at Clemson University, South Carolina, and beyond. The goal will be achieved by three specific aims: Aim 1: expand and sustain the design and rapid prototyping capabilities to enable TRIMH researchers to quickly design and build simulated musculoskeletal components, systems or environments that are physical and biological replica of the human models, Aim 2: expand and sustain the sensor, instrumentation, and testing capabilities to enable the investigators to design, fabricate and install sensors onto the physical and biological replica for in situ measurement of various parameters and validation of the virtual human models, and Aim 3: promote and sustain the AFT core as a leading biomedical engineering “go-to-place” for musculoskeletal research at Clemson University, the state of South Carolina, and beyond. The AFT Core will be led by a multidisciplinary team with the combined expertise in engineering designs (mechanical, optical, electrical, and material), advanced manufacturing, rapid prototyping, sensors, instrumentation, imaging, and advanced testing. The COBRE funds will continue to support experienced staff members to operate/maintain the consolidated facilities, to train/mentor TRIMH investigators to translate their innovations into clinical successes, to further enhance the capability of the core, and to facilitate the transition of the AFT Core to a competitive and self- sustained program.

摘要 先进制造和测试(AFT)核心是SC-TRIMH的启动技术引擎。它 在克莱姆森大学收获独特的工程优势和能力来支持这项研究 项目，并加快将其创新转化为针对患者的诊断和治疗 分子、细胞、组织和身体层面的肌肉骨骼疾病。在第一阶段，AFT核心扩展 现在占地超过4,400平方英尺，将所有服务整合到一座新大楼中，以提供更多 为电气、机械、光学和材料设计、快速成型、传感器和 仪器，以及为TRIMH调查人员提供的高级测试。核心还扩展了它的仪器 (例如，集成的加法和减法制造，加上用于超快微加工的飞秒激光) 通过美国能源部颁发的奖项和TRIMH增刊。在此期间，AFT核心向所有8个TRIMH提供服务 研究项目负责人(RPL)、其他8名TRIMH试点项目负责人和12名克莱姆森项目负责人。其他七个PI 南卡罗来纳州(SC)和其他6个州以外的SC使用此核心；以及三个工业客户。 这一核心对于那些在工程学科中没有主要专业知识的人尤其重要，因为 我们既有交钥匙服务，也有量身定做的“牵手”/指导。第一阶段的AFT核心支持 近50个私人投资机构，为30个赠款申请作出了贡献，并出版了30多份出版物。在第二阶段，我们 将支持所有4个RPL的研究项目，同时我们将继续扩大和维持工程 能力，并努力将AFT核心打造成领先的生物医学工程资源，特别是 南卡罗来纳州克莱姆森大学和其他地方的肌肉骨骼相关研究。目标一定会实现的 通过三个具体目标：目标1：扩大和维持设计和快速成型能力，以实现TRIMH 研究人员快速设计和构建模拟肌肉骨骼组件、系统或环境 是人体模型的物理和生物复制品，目标2：扩展和维持传感器、仪器、 和测试能力，使调查人员能够设计、制造和安装传感器到物理和 用于各种参数的现场测量和虚拟人体模型的验证的生物复制品，以及 目标3：促进和维持AFT核心作为肌肉骨骼领域领先的生物医学工程 在克莱姆森大学、南卡罗来纳州和更远的地方进行的研究。AFT核心将由一名 多学科团队，拥有工程设计(机械、光学、电气和 先进制造、快速成型、传感器、仪器仪表、成像和先进测试。 科布雷基金将继续支持有经验的工作人员运营/维护合并后的 设施，培训/指导TRIMH研究人员将他们的创新转化为临床成功，以进一步 提升核心能力，促进AFT核心向具有竞争力和自主性的转型 持续的计划。