Advanced Fabrication and Testing Core (AFT)

先进制造和测试核心 (AFT)

• 批准号: 10714165
• 负责人: Hai Xiao
• 金额: $ 28.96万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714165
• 关键词: 3-Dimensional; 3D Print; Applications Grants; Area; Automation; Award; Biocompatible Materials; Biological; Biomedical Engineering; Centers of Research Excellence; Ceramics; Client; Clinical; Complex; Diagnosis; Discipline; Engineering; Equipment; Event; Funding; Generations; Glass; Goals; Grant; Hand; Harvest; Health; Image; Imaging technology; In Situ; Industrialization; Lasers; Light; Measurement; Mechanics; Mentors; Metals; Mind; Molecular; Musculoskeletal; Musculoskeletal Diseases; Optics; Patients; Phase; Physical environment; Pilot Projects; Procedures; Process; Program Sustainability; Publications; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Secure; Services; Source; South Carolina; Standardization; Strategic Planning; System; Technology; Testing; Time; Tissues; Training; Training Activity; Translating; Translations; United States National Institutes of Health; Universities; Validation; Work; data acquisition; design; engineering design; experience; fabrication; graphical user interface; human model; improved; innovation; instrument; instrumentation; manufacture; manufacturing systems; meetings; member; models and simulation; multidisciplinary; operation; programs; prototype; second harmonic; sensor; signal processing; success; technological innovation; tool; virtual human

SUMMARY The Advanced Fabrication and Testing (AFT) Core is the enabling technological engine of the SC-TRIMH. It harvests the unique engineering strengths and capabilities at Clemson University to support the research projects and expedite the translation of their innovations to patient-specific diagnosis and treatments of musculoskeletal diseases at the molecular, cellular, tissue, and body levels. In Phase I, the AFT Core expanded to now cover over 4,400 sq ft when it consolidated all its services in a new building in order to provide more centralized services for electrical, mechanical, optical, and material designs, rapid prototyping, sensors and instrumentation, and advanced testing for the TRIMH investigators. The core also expanded its instrumentation (e.g. integrated additive and subtractive manufacturing, plus femtosecond laser for ultrafast micromachining) via awards from DOE and a TRIMH supplement. During this time the AFT Core provided services to all 8 TRIMH Research Project Leaders (RPL), 8 other TRIMH Pilot Project Leaders, and 12 Clemson PIs. Seven other PIs from the state of South Carolina (SC) and 6 others outside SC used this core; along with three industrial clients. This core is especially important to those who do not have primary expertise in the engineering disciplines, as we have both turnkey services and tailored “hand holding”/mentoring. The AFT core in Phase I has supported nearly 50 PIs, contributed to 30 grant applications, and generated more than 30 publications. In Phase II, we will be supporting the research projects of all 4 RPLs while we continue to expand and sustain the engineering capabilities and strive to build the AFT Core into a leading biomedical engineering resource, especially for musculoskeletal related research at Clemson University, South Carolina, and beyond. The goal will be achieved by three specific aims: Aim 1: expand and sustain the design and rapid prototyping capabilities to enable TRIMH researchers to quickly design and build simulated musculoskeletal components, systems or environments that are physical and biological replica of the human models, Aim 2: expand and sustain the sensor, instrumentation, and testing capabilities to enable the investigators to design, fabricate and install sensors onto the physical and biological replica for in situ measurement of various parameters and validation of the virtual human models, and Aim 3: promote and sustain the AFT core as a leading biomedical engineering “go-to-place” for musculoskeletal research at Clemson University, the state of South Carolina, and beyond. The AFT Core will be led by a multidisciplinary team with the combined expertise in engineering designs (mechanical, optical, electrical, and material), advanced manufacturing, rapid prototyping, sensors, instrumentation, imaging, and advanced testing. The COBRE funds will continue to support experienced staff members to operate/maintain the consolidated facilities, to train/mentor TRIMH investigators to translate their innovations into clinical successes, to further enhance the capability of the core, and to facilitate the transition of the AFT Core to a competitive and self- sustained program.

概括 高级制造和测试（AFT）核心是SC-Trimh的启用技术引擎。它 收获克莱姆森大学独特的工程优势和能力来支持这项研究 项目并加快将其创新转化为患者特定的诊断和治疗 分子，细胞，组织和身体水平的肌肉骨骼疾病。在第一阶段，船尾芯扩展了 现在，当它在新建筑物中合并其所有服务时，覆盖了4,400平方英尺以上 电气，机械，光学和材料设计，快速原型制作，传感器和 仪器和Trimh研究人员的高级测试。核心还扩大了其仪器 （例如，集成添加剂和减法制造，以及超快微加工的飞秒激光） 通过DOE和TRIMH补充剂的奖项。在此期间，AFT核心为所有8个Trimh提供服务 研究项目负责人（RPL），其他8位TRIMH试点项目领导者和12名Clemson PI。其他七个pis 来自南卡罗来纳州（SC）和SC以外的6个核心使用此核心；以及三个工业客户。 对于那些在工程学科中没有主要专业知识的人来说，此核心尤其重要，因为 我们既有交钥匙服务，又有量身定制的“手持”/指导。第一阶段的船尾核心支持 将近50个PI，贡献了30份赠款申请，并生成了30多个出版物。在第二阶段，我们 在我们继续扩展和维持工程学的同时，将支持所有4个RPL的研究项目 能力并努力将船尾核心建立为领先的生物医学工程资源，尤其是 南卡罗来纳州克莱姆森大学及其他地区的肌肉骨骼相关研究。目标将实现 通过三个具体目标：目标1：扩展和维持设计和快速原型制作功能，以实现Trimh 研究人员快速设计和建立模拟的肌肉骨骼组件，系统或环境 是人类模型的物理和生物学复制品，目标2：扩展和维持传感器，仪器， 以及测试功能，使研究人员能够设计，制造和安装传感器 用于原位测量各种参数和验证虚拟人类模型的生物复制品，以及 AIM 3：促进和维持船尾的领先生物医学工程的“肌肉骨骼” 克莱姆森大学，南卡罗来纳州及其他地区的研究。船尾核心将由 具有工程设计的联合专业知识（机械，光学，电气和 材料），高级制造，快速原型制造，传感器，仪器，成像和高级测试。 COBRE资金将继续支持经验丰富的员工运营/维护合并的 设施，培训/导师Trimh调查人员，将其创新转化为临床成功，以进一步 增强核心的能力，并促进船尾核心向竞争性和自我 持续计划。