Computer-Based Training in Cognitve Behavioral Therapy

本建议书要求延长基于计算机的R37优秀奖 认知行为疗法的训练：CBT 4 CBT的第一阶段试验。在过去的三年里，我们 已完成计算机辅助培训计划，并有望完成随机试验 在基于社区的药物滥用环境中评估这种方法，如原文所述 明确的目标。我们还启动了全面的神经认知电池和功能磁共振扫描 对于随机试验中所有符合条件的参与者，以评估神经生物学可能与 对CBT的反应。 对于延长期，我们建议(1)在现有的CBT4CBT计划基础上增加一个模块， 摘自NIDA CBT手册，将解决艾滋病毒危险行为，(2)扩大患者多样性和 通过进行一项新的平行试验，评估CBT4CBT方案与新的艾滋病毒模块的效果 对80名服用美沙酮的有艾滋病毒风险的吸毒者进行的随机试验，(3)扩大 神经认知和神经成像组件目前由R37的一个补充 提出了新的美沙酮试验，以及(4)增加了一项新的行为遗传学研究，将评估 哪些COMT Met/Met与Vala/al基因型的个体预测对CBT的反应。

This proposal is a REQUEST FOR EXTENSION OF MERIT AWARD for R37 DA015969) Computer Based Training in Cognitive Behavioral Therapy: A Stage I Trial of "CBT 4 CBT". During the past 3 years, we have completed the computer-assisted training program and are on track to complete the randomized trial evaluating this approach within a community-based substance abuse setting as described in the original specific aims. We have also initiated a comprehensive neurocognitive battery and functional MRI scanning for all eligible participants in the randomized trial, in order to evaluate neurobiological possible correlates of response to CBT. For the extension period, we propose to (1) add one additional module to the existing CBT4CBT program, drawn from the NIDA CBT manual, that will address HIV risk behaviors, (2) expand patient diversity and evaluate the efficacy of the CBT4CBT program with the new HIV module by conducting a new parallel randomized trial with 80 drug -using individuals maintained on methadone who are at risk for HIV, (3) extend the neurocognitive and neuroimaging components currently funded by a supplement to the R37 to the proposed new methadone trial, and (4) add a novel behavioral genetics study that will evaluate the extent to which individuals with the COMT Met/Met versus the ValA/al genotype predict response to CBT.