A Stage I Study of Computer Based Training in CBT for Alcohol Use Disorders

基于计算机的酒精使用障碍 CBT 培训的第一阶段研究

• 批准号: 8503575
• 负责人: KATHLEEN M. CARROLL
• 金额: $ 18.97万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-05 至 2014-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8503575
• 关键词: Address; Alcohol consumption; Alcohol dependence; Alcohols; Back; Behavior Therapy; Behavioral; Benchmarking; Case Management; Characteristics; Clinical; Cognitive Therapy; Computer Assisted; Computer-Assisted Therapy; Coping Skills; Counseling; Dependence; Development; Drug Addiction; Drug usage; Enhancers; Evaluation; Evidence based treatment; Exploratory/Developmental Grant; Funding; Heavy Drinking; Illicit Drugs; Individual; Interview; Measures; Mediator of activation protein; Methods; Monitor; National Institute on Alcohol Abuse and Alcoholism; Online Systems; Outcome; Outcome Measure; Outpatients; Participant; Population; Program Development; Program Evaluation; Public Health; Randomized; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Research; Safety; Security; Specific qualifier value; Specificity; Staging; Testing; Time; TimeLine; Training; Treatment Cost; Underserved Population; alcohol abuse therapy; alcohol use disorder; base; clinical practice; computer assisted patient care; computer studies; design; drinking; evidence base; follow-up; meetings; novel; primary outcome; programs; psychosocial; randomized trial; secondary outcome; standard care; three-arm study; treatment effect; treatment strategy; virtual; web site

DESCRIPTION (provided by applicant): Computer-assisted treatments have tremendous potential for making evidence based therapies more widely available to those who may benefit from them, standardizing treatment delivery, extending and freeing up the time of busy clinicians, and reducing the costs of treatment. Despite their enormous promise, however, well- controlled randomized clinical trials of computer-assisted therapies remain rare, and there are fewer still that would meet established methodological standards for the evaluation of clinician-delivered behavioral therapies. We have developed a computer-assisted version of CBT (CBT4CBT) and have demonstrated its efficacy, durability, and specificity as an adjunct to outpatient treatment for illicit drug dependence. In 2009, we were approached by NIAAA to develop a web-based version of CBT4CBT specifically for individuals with alcohol use disorders, as there are no existing full-scale computer-assisted CBT programs for alcohol use disorders with demonstrated efficacy. Funded through ARRA, development of the web based CBT4CBT alcohol program was completed in 2011, within our specified timeline. We now propose an exploratory, Stage I study to evaluate the program's feasibility and preliminary efficacy with treatment-seeking alcohol dependent individuals. We propose to conduct an 8-week randomized clinical trial with 90 treatment-seeking individuals meeting current criteria for alcoho dependence. Participants will be randomized to one of three conditions: (1) standard outpatient counseling, (2) counseling plus CBT4CBT (the website delivered as an add-on to standard counseling, or (3) web-based CBT4CBT as a virtual standalone (CBT4CBT plus minimal clinical monitoring). This design is novel for a Stage 1 study in that it will allow evaluation of the program in two of the forms in which it is most likely to be implemented clinically (add-on and stand alone). The primary outcome measures will be reduction in alcohol use (percent days abstinent, heavy drinking days by week). Measures of treatment utilization and other secondary outcomes will be used to evaluate whether web-based CBT4CBT retains key characteristics of traditional clinician-delivered CBT (e.g., acquisition of coping skills, use of change strategies).

描述（由申请人提供）：计算机辅助治疗具有使可能从中受益的人更广泛地使用基于证据的疗法，标准化治疗，延长和释放忙碌的临床医生的时间，并降低治疗费用。但是，尽管有巨大的希望，但控制良好的计算机辅助疗法的随机临床试验仍然很少见，而且较少的方法符合既定的方法论标准，以评估临床医生分娩的行为疗法。我们已经开发了CBT（CBT4CBT）的计算机辅助版本，并证明了其功效，耐用性和特异性是门诊治疗非法药物依赖性的辅助性。在2009年，NIAAA与我们联系，开发了专门针对酒精使用障碍个体的基于网络的CBT4CBT版本，因为没有现有的用于酒精使用障碍的全面计算机辅助CBT程序具有效果。通过ARRA资助，基于Web的CBT4CBT酒精计划的开发在我们指定的时间表中于2011年完成。现在，我们提出了一项探索性，我的研究，以评估该计划的可行性和初步疗效，以寻求治疗的依赖酒精。我们建议进行为期8周的随机临床试验，其中90个寻求治疗的人满足酒精依赖的当前标准。参与者将被随机分配到以下三个条件之一：（1）标准的门诊咨询，（2）咨询加上CBT4CBT（作为标准咨询的附加方式提供的网站，或（3）基于Web的CBT4CBT作为虚拟独立酮（CBT4CBT Plus最小临床监测），这将允许Is Is Is Is Is Is Is Is Is Is In Is Is Is In Is Iss in Stage in Specation。可能会在临床上实施（单独的附加组件和独立措施）。

项目成果

Identification and expression profile analysis of NUCLEAR FACTOR-Y families in Physcomitrella patens.

小立碗藓核因子-Y 家族的鉴定和表达谱分析。

• DOI: 10.3389/fpls.2015.00642
• 发表时间: 2015
• 期刊: Frontiers in plant science
• 影响因子: 5.6
• 作者: Zhang F;Han M;Lv Q;Bao F;He Y
• 通讯作者: He Y

High-yield production of extracellular type-I cellulose by the cyanobacterium Synechococcus sp. PCC 7002.

• DOI: 10.1038/celldisc.2015.4
• 发表时间: 2015
• 期刊: Cell discovery
• 影响因子: 33.5
• 作者: Zhao C;Li Z;Li T;Zhang Y;Bryant DA;Zhao J
• 通讯作者: Zhao J

Preparation and characterization of a highly stable phenoxazinone synthase nanogel.

• DOI: 10.1186/s13065-016-0178-8
• 发表时间: 2016
• 期刊: Chemistry Central journal
• 作者: Jia H;Gao Z;Ma Y;Zhong C;Wang C;Zhou H;Wei P
• 通讯作者: Wei P

Kinetics of Inactivation of Bacillus subtilis subsp. niger Spores and Staphylococcus albus on Paper by Chlorine Dioxide Gas in an Enclosed Space.

枯草芽孢杆菌亚种灭活动力学。

• DOI: 10.1128/aem.03940-15
• 发表时间: 2016
• 期刊: Applied and environmental microbiology
• 影响因子: 4.4
• 作者: Wang,Tao;Wu,Jinhui;Qi,Jiancheng;Hao,Limei;Yi,Ying;Zhang,Zongxing
• 通讯作者: Zhang,Zongxing

A pilot study on using chlorine dioxide gas for disinfection of gastrointestinal endoscopes.

二氧化氯气体用于胃肠内窥镜消毒的初步研究

• DOI: 10.1631/jzus.b1500327
• 发表时间: 2016
• 期刊: Journal of Zhejiang University. Science. B
• 作者: Yi,Ying;Hao,Li-Mei;Ma,Shu-Ren;Wu,Jin-Hui;Wang,Tao;Lin,Song;Zhang,Zong-Xing;Qi,Jian-Cheng
• 通讯作者: Qi,Jian-Cheng