Non B DNA Structure with Chemical Carcinogens
含有化学致癌物质的非 B DNA 结构
基本信息
- 批准号:7909158
- 负责人:
- 金额:$ 32.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-01 至 2011-07-31
- 项目状态:已结题
- 来源:
- 关键词:AdultArchitectureCell NucleusCellsChromatinComplexDNA SequenceDNA StructureDataDevelopmentGene ExpressionGenesGenomeGenomicsHeterochromatinKnockout MiceMemoryNuclearNuclear ProteinNuclear ProteinsResearchRoleStem cellscancer typecell typechemical carcinogenchromatin remodelingprogramsprotein distributionprotein folding
项目摘要
Accumulated evidence suggests that higher-order organization of chromatin is important in gene
expression. However, little is known about how genomes are folded and organized in the cell so
that specific genes are properly regulated in a cell-type specific manner. Our research group
identified a nuclear protein SATB1, which has a unique function as a 'genome organizer'. We
found that SATB1 has a 'cage-like' protein distribution surrounding the heterochromatin, and this
protein folds chromatin by tethering specialized DNA sequences. SATB1 serves as a landing
platform for the assembly of chromatin remodeling/modifying complexes with the specialized
DNA sequences, thereby regulating expression of a large body of genes. Thus, SATB1 sets up
a functional nuclear architecture, referred to as 'the SATB1 network', since it establishes a
regulatory network with the capacity to re-program gene expression. In fact, our most recent
data show that the SATB1 nuclear architecture is important in cells acquiring new functions. We
plan to investigate the roles of SATB1 in the progression of different types of cancer and in
development of some adult progenitor cells using conditional SATB1 knockout mice. We will
also study how SATB1 spatially organizes genomic loci in the nuclei and whether it contributes
in the mechanisms underlying cell memory.
越来越多的证据表明,染色质的高级结构在基因表达中起着重要的作用。
表情然而,人们对基因组在细胞中是如何折叠和组织的知之甚少,
特定的基因以细胞类型特异性的方式被适当地调节。本课题组
鉴定了核蛋白SATB 1,其具有作为“基因组组织者”的独特功能。我们
发现SATB 1在异染色质周围有一个“笼状”蛋白分布,
蛋白质通过固定特殊的DNA序列折叠染色质。SATB 1用作着陆点
用于组装染色质重塑/修饰复合物的平台,
DNA序列,从而调节大量基因的表达。因此,SATB 1设置
一个功能性的核架构,被称为“SATB 1网络”,因为它建立了一个
具有重新编程基因表达能力的调控网络。事实上,我们最近的
数据显示SATB 1核结构在细胞获得新功能中是重要的。我们
计划研究SATB 1在不同类型癌症进展中的作用,
使用条件性SATB 1敲除小鼠开发一些成体祖细胞。我们将
我还研究了SATB 1如何在细胞核中空间组织基因组位点,以及它是否有助于
细胞记忆的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Terumi Kohwi-Shigematsu其他文献
Terumi Kohwi-Shigematsu的其他文献
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{{ truncateString('Terumi Kohwi-Shigematsu', 18)}}的其他基金
Genome organizer SATB1 function in salivary gland and development and growth
基因组组织者 SATB1 在唾液腺及其发育和生长中的功能
- 批准号:
10593721 - 财政年份:2023
- 资助金额:
$ 32.6万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9244030 - 财政年份:2014
- 资助金额:
$ 32.6万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
8675078 - 财政年份:2014
- 资助金额:
$ 32.6万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
8865636 - 财政年份:2014
- 资助金额:
$ 32.6万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9213517 - 财政年份:2014
- 资助金额:
$ 32.6万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9484083 - 财政年份:2014
- 资助金额:
$ 32.6万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9043728 - 财政年份:2014
- 资助金额:
$ 32.6万 - 项目类别:
CHARACTERIZATION OF SATB1 MODIFICATIONS FOLLOWING IONIZATION RADIATION
电离辐射后 SATB1 修饰的表征
- 批准号:
8170703 - 财政年份:2010
- 资助金额:
$ 32.6万 - 项目类别:
Determinants for genome-wide epigenomics in metastatic breast cancer
转移性乳腺癌全基因组表观基因组学的决定因素
- 批准号:
7726410 - 财政年份:2009
- 资助金额:
$ 32.6万 - 项目类别:
Determinants for genome-wide epigenomics in metastatic breast cancer
转移性乳腺癌全基因组表观基因组学的决定因素
- 批准号:
8301480 - 财政年份:2009
- 资助金额:
$ 32.6万 - 项目类别:
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