CHARACTERIZATION OF SATB1 MODIFICATIONS FOLLOWING IONIZATION RADIATION
电离辐射后 SATB1 修饰的表征
基本信息
- 批准号:8170703
- 负责人:
- 金额:$ 3.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-01 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAffinityBinding ProteinsComputer Retrieval of Information on Scientific Projects DatabaseDNAFundingGenesGoalsGrantHistone CodeInstitutionLaboratoriesModificationNuclearPost-Translational Protein ProcessingProteinsRadiationRegulator GenesResearchResearch PersonnelResourcesSignal TransductionSourceStagingStem cellsTestingUnited States National Institutes of Healthadult stem cellbasecell typeembryonic stem cellionizationirradiationresponsethymocyte
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Introduction and Rationale A major goal of my laboratory has been to understand the fundamental mechanisms by which a large body of genes is directed to be either expressed or repressed in a cell-type or stage-specific manner or in response to signals from outside. In this context, we identified a nuclear architectural protein, SATB1, which functions as a global gene regulator, expressed in embryonic stem (ES) cells and adult progenitor cells, such as thymocytes. Using a DNA affinity column containing BUR (base unpairing region) specifically recognized by SATB1, we wish to identify SATB1 associated proteins as well as new BUR-binding proteins in stem cells and adult progenitor cells. Furthermore, we wish to test a hypothesis that the SATB1 protein undergoes changes in post-translational modification during differentiation or upon irradiation. The goal of the project is to assign specific functions to each type of post-translational modification of the SATB1 protein, similar to the concept of the 'histone code'.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Terumi Kohwi-Shigematsu其他文献
Terumi Kohwi-Shigematsu的其他文献
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{{ truncateString('Terumi Kohwi-Shigematsu', 18)}}的其他基金
Genome organizer SATB1 function in salivary gland and development and growth
基因组组织者 SATB1 在唾液腺及其发育和生长中的功能
- 批准号:
10593721 - 财政年份:2023
- 资助金额:
$ 3.21万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9244030 - 财政年份:2014
- 资助金额:
$ 3.21万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
8675078 - 财政年份:2014
- 资助金额:
$ 3.21万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
8865636 - 财政年份:2014
- 资助金额:
$ 3.21万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9213517 - 财政年份:2014
- 资助金额:
$ 3.21万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9484083 - 财政年份:2014
- 资助金额:
$ 3.21万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9043728 - 财政年份:2014
- 资助金额:
$ 3.21万 - 项目类别:
Determinants for genome-wide epigenomics in metastatic breast cancer
转移性乳腺癌全基因组表观基因组学的决定因素
- 批准号:
7726410 - 财政年份:2009
- 资助金额:
$ 3.21万 - 项目类别:
Non B DNA Structure with Chemical Carcinogens
含有化学致癌物质的非 B DNA 结构
- 批准号:
7909158 - 财政年份:2009
- 资助金额:
$ 3.21万 - 项目类别:
Determinants for genome-wide epigenomics in metastatic breast cancer
转移性乳腺癌全基因组表观基因组学的决定因素
- 批准号:
8525100 - 财政年份:2009
- 资助金额:
$ 3.21万 - 项目类别:
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