MIDLIFE COGNITIVE CHANGE AND RISK OF COGNITIVE DECLINE

中年认知变化和认知衰退的风险

• 批准号: 7848504
• 负责人: SHERRY L WILLIS
• 金额: $ 13.12万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2011-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7848504
• 关键词: Accounting; Adult; Age; Age-Years; Alleles; Alzheimer' s Disease; Alzheimer' s disease risk; Apolipoprotein E; Atrophic; Brain; Brain region; Chronic Disease; Clinical; Cognition; Cognitive; Data; Dementia; Development; Diabetes Mellitus; Diagnosis; Disease; Elderly; Episodic memory; Exhibits; Generations; Genotype; Goals; Growth; Health; Health Policy; Health behavior; Hippocampus (Brain); Hypertension; Impaired cognition; Impairment; Lead; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediator of activation protein; Medical History; Memory; Participant; Pathology; Pattern; Prospective Studies; Psyche structure; Psychometrics; Public Health; Recording of previous events; Reporting; Research; Research Personnel; Risk; Sampling; Speed; Subgroup; Testing; Vascular Diseases; brain volume; cognitive change; cognitive function; cognitive reserve; cohort; cost; effective therapy; episodic memory impairment; executive function; experience; frontal lobe; high risk; interest; member; middle age; neuropsychological; normal aging; policy implication; processing speed; programs; prospective; white matter

The overall goal of this project is to examine whether cognitive status and cognitive change in middle age are predictive of rate of subsequent decline. While stability is the normative pattern for most mental abilities in midlife, longitudinal studies of normal aging have reported subgroups of middle-aged adults who show reliable decline or improvement on specific cognitive abilities. Adults who exhibit early decline in midlife on select abilities may be at higher risk for an accelerated rate of cognitive decline in old age. Study participants (N = 653) will be members from the Seattle Longitudinal Study (SLS) with longitudinal cognitive data obtained during midlife. Midlife cognitive change data will be used to identify patterns of change and to develop Midlife Cognitive Risk criteria for three domains: Episodic memory, Executive functioning, and Processing speed. The impact of midlife cognition will be studied for two cohorts. For the Older Cohort (b1914 -1941; M age = 75; N = 332) cognitive data are available in midlife and also in old age. For the Middle Age Cohort (b1942 -1962; N = 321; M age = 55) cognitive change data are available in midlife. The sample will be further characterized by neuropsychological assessment, APOE genotyping, and health histories. To examine the association of brain volume and cognitive change, baseline measures and rate of atrophy in the hippocampus, entorhinal cortex.prefrontal cortex and frontal white matter will be assessed by structural MRI at two occasions. Longitudinal data on participants' engagement in stimulating cognitive activities will also be studied as a mediator of cognitive change.

该项目的总体目标是检查认知状况和认知变化是否 中年可以预测随后下降的速度。稳定性是规范模式 中年的大多数心理能力，正常衰老的纵向研究报告了 在特定认知能力上表现出可靠下降或改善的中年成年人。成年人 在某些能力方面表现出中年早期下降的人可能会加速率更高的风险 老年认知能力下降。研究参与者（n = 653）将是西雅图的成员 纵向研究（SLS）具有中年期间获得的纵向认知数据。中年认知 变更数据将用于识别变化模式并制定中年认知风险标准 对于三个领域：情节记忆，执行功能和处理速度。的影响 将研究两个人群的中年认知。对于较旧的队列（B1914 -1941; m age = 75; n = 332）认知数据可在中年和老年中获得。对于中年队列 （B1942 -1962; n = 321; m age = 55）认知变化数据可在中年使用。样本将 进一步以神经心理学评估，APOE基因分型和健康为特征 历史。为了检查大脑体积和认知变化的关联，基线测量 海马，内嗅皮层的萎缩率和萎缩。 将两次通过结构MRI评估。参与者参与的纵向数据 在刺激认知活动中，还将作为认知变化的调解人进行研究。