MIDLIFE COGNITIVE CHANGE AND RISK OF COGNITIVE DECLINE

中年认知变化和认知衰退的风险

• 批准号: 8113913
• 负责人: SHERRY L WILLIS
• 金额: $ 50.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8113913
• 关键词: Adult; Age; Alleles; Atrophic; Biological Markers; Birth; Brain; Brain region; Cardiovascular system; Caring; Cerebrovascular Circulation; Cognition; Cognition Disorders; Cognitive; Cognitive aging; Comorbidity; Data; Dementia; Diabetes Mellitus; Early Diagnosis; Education; Elderly; Episodic memory; Equation; Exhibits; Genotype; Goals; Growth; Health; Hippocampus (Brain); Hypertension; Impaired cognition; Individual; Individual Differences; Instruction; Life Style; Longitudinal Studies; Magnetic Resonance Imaging; Mediator of activation protein; Memory; Modeling; Participant; Pattern; Performance; Phase; Prefrontal Cortex; Psyche structure; Recording of previous events; Reporting; Risk; Sampling; Societies; Speed; Structure; Subgroup; Ursidae Family; aging brain; brain volume; cerebral atrophy; cognitive change; cohort; cost; demographics; entorhinal cortex; executive function; flexibility; gray matter; high risk; interest; member; middle age; neuropsychological; normal aging; pre-clinical; processing speed; white matter

PROJECT SUMMARY (See instructions): The overall goal of this project is to examine whether cognitive status and cognitive change in middle age are predictive of rate of subsequent decline. While stability is the normative pattern for most mental abilities in midlife, longitudinal studies of normal aging have reported subgroups of middle-aged adults who show reliable decline or improvement on specific cognitive abilities. Adults who exhibit early decline in midlife on select abilities may be at higher risk for an accelerated rate of cognitive decline in old age. Study participants (N = 698) are members from the Seattle Longitudinal Study (SLS) with longitudinal cognitive data obtained during midlife. Midlife cognitive change data has been used to identify patterns of change and to develop Midlife Cognitive Risk criteria for three domains: Episodic memory. Executive functioning, and Processing Speed. The impact of midlife cognition is being studied for two cohorts. For the Older Cohort (b1914 - 1941; M age = 77; N = 270), cognitive data are available in midlife and also in old age. For the Middle Age cohort (b1942 - 1969); N = 428; M age = 59) cognitive change data are available in midlife and early old age. The sample is further characterized by neuropsychological assessment, APO-E genotyping, and health histories. To examine the association of brain volume and cognitive change, rate of atrophy in the hippocampus, entorhinal cortex, prefrontal cortex and frontal white matter are being assessed by structural MRI at.four occasions..Xongitudinal..data.on.participants' engagement in stimulating cognitive activities is also being studied as a mediator of cognitive change.

项目摘要（请参阅说明）： 该项目的总体目标是检查中年认知状况和认知变化是否 可以预测随后下降的速度。稳定性是大多数心理能力的规范模式 在中年，正常衰老的纵向研究报告了中年成年人的亚组 特定认知能力的可靠下降或改善。中年早期表现出早期下降的成年人 精选能力可能面临高年龄认知能力下降速度的较高风险。 研究参与者（n = 698）是来自西雅图纵向研究（SLS）的成员 中年获得的认知数据。中年认知变化数据已用于识别 改变并制定三个领域的中年认知风险标准：情节记忆。管理人员 功能和处理速度。正在研究两个人群中期认知的影响。为了 较旧的队列（B1914-1941; m age = 77; n = 270），认知数据在中年以及在旧的情况下提供 年龄。对于中年队列（B1942-1969）； n = 428; m age = 59）认知变化数据可在 中年和老年。样本的进一步特征是神经心理学评估，apo-e 基因分型和健康历史。为了检查大脑体积和认知变化的关联， 正在评估海马，内嗅皮层，前额叶皮层和额叶白质的萎缩 通过结构性MRI在四场比赛中 活动还作为认知变化的调解人进行了研究。