MIDLIFE COGNITIVE CHANGE AND RISK OF COGNITIVE DECLINE

中年认知变化和认知衰退的风险

• 批准号: 7278502
• 负责人: SHERRY L WILLIS
• 金额: $ 3.9万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278502
• 关键词: age difference; apolipoprotein E; behavioral /social science research tag; brain imaging /visualization /scanning; brain morphology; cardiovascular disorder; clinical research; cognition; cognition disorders; dementia; diabetes mellitus; disease /disorder proneness /risk; entorhinal cortex; executive function; hippocampus; human middle age (35-64); human old age (65+); human subject; longitudinal human study; magnetic resonance imaging; memory; neural information processing; neuropsychological tests; prefrontal lobe /cortex; prognosis; psychological aspect of aging

DESCRIPTION (provided by applicant): The overall goal of this project is to examine whether cognitive status and cognitive change in middle age are predictive of rate of subsequent decline. While stability is the normative pattern for most mental abilities in midlife, longitudinal studies of normal aging have reported subgroups of middle-aged adults who show reliable decline or improvement on specific cognitive abilities. Adults who exhibit early decline in midlife on select abilities may be at higher risk for an accelerated rate of cognitive decline in old age. Study participants (N = 653) will be members from the Seattle Longitudinal Study (SLS) with longitudinal cognitive data obtained during midlife. Midlife cognitive change data will be used to identify patterns of change and to develop Midlife Cognitive Risk criteria for three domains: Episodic memory, Executive functioning, and Processing speed. The impact of midlife cognition will be studied for two cohorts. For the Older Cohort (b1914 -1941; M age = 75; N = 332) cognitive data are available in midlife and also in old age. For the Middle Age Cohort (b1942 -1962; N = 321; M age = 55) cognitive change data are available in midlife. The sample will be further characterized by neuropsychological assessment, APOE genotyping, and health histories. To examine the association of brain volume and cognitive change, baseline measures and rate of atrophy in the hippocampus, entorhinal cortex.prefrontal cortex and frontal white matter will be assessed by structural MRI at two occasions. Longitudinal data on participants' engagement in stimulating cognitive activities will also be studied as a mediator of cognitive change.

描述（由申请人提供）：该项目的总体目标是检查中年认知状况和认知变化是否可以预测随后下降的率。尽管稳定性是中年生活大多数心理能力的规范模式，但对正常衰老的纵向研究报告了中年成年人的亚组，这些中年成年人对特定认知能力表现出可靠的下降或提高。在某些能力方面表现出早期寿命早期下降的成年人可能会因老年认知能力下降的速度加速而面临更高的风险。研究参与者（n = 653）将是西雅图纵向研究（SLS）的成员，并在中年时获得了纵向认知数据。中年认知变化数据将用于识别变化模式并制定三个领域的中年认知风险标准：情节记忆，执行功能和处理速度。将研究中年认知的影响。对于较旧的队列（B1914 -1941; M Age = 75; n = 332）认知数据在中年和老年都可以使用。对于中年队列（B1942 -1962; n = 321; m age = 55）认知变化数据在中年有可用。样本将进一步以神经心理学评估，APOE基因分型和健康历史为特征。为了检查脑体积和认知变化的关联，海马，内嗅皮层的基线测量和萎缩速率。额外皮层和额叶白质将通过两次结构MRI评估。有关参与者参与刺激认知活动的纵向数据也将作为认知变化的中介。