Early Cortical Processing In Schizophrenia

精神分裂症传统上与涉及皮层的高阶处理缺陷有关， 例如前额或颞海马脑区。然而，最近， 感觉加工的早期阶段也已被证实。在听觉系统中，精神分裂症 患者表现出不匹配负波（MMN）的产生受损，MMN是神经生理学指标， 听觉感觉皮层水平的功能障碍，沿着听觉N1的产生受损。赤字 在MMN产生中与音调匹配测试中的表现缺陷相关，反映了受损的 听觉感觉记忆（ASM）类似的缺陷现在已经记录在视觉 系统因此，精神分裂症患者显示出关闭碎片图像的能力受损，反映了 外侧枕叶皮质（LO）水平的功能障碍。此外，P1视觉成分的振幅是 在背侧流区域减少，而腹侧流P1和N1分量的振幅是 相对完整。视觉结果与视觉处理受损一致，特别是在 大细胞视觉通路和受损的背/腹系统相互作用。的总体目标 本研究的目的是进一步明确听觉和听觉系统神经生理功能障碍的机制， 视觉系统缺陷并评估单个潜在缺陷（例如，NMDA 功能障碍）可以解释观察到的功能障碍的模式。最后，该项目将开始， 评估听觉和视觉处理中的单独缺陷导致以下损害的程度： 高阶过程。 与公共卫生的相关性：精神分裂症是一种严重的精神障碍， 全球人口。认知功能的缺陷预示着不良的结果和持续的残疾。这 该项目将分析认知功能障碍的神经基础。

Schizophrenia has traditionally been associated with deficits in high order processing involving cortical regions such as prefrontal or temporohippocampal brain regions. More recently, however, dysfunction of early stages of sensory processing have been demonstrated as well. In the auditory system, schizophrenia patients show impaired generation of mismatch negativity (MMN), an index of neurophysiological dysfunction at the level of auditory sensory cortex, along with impaired generation of auditory N1. Deficits in MMN generation correlate with deficits in performance on tests of tone matching, reflecting impaired auditory sensory memory(ASM) performance. Similar deficits have now been documented in the visual system. Thus, patients with schizophrenia show impaired ability to close fragmented images, reflecting dysfunction at the level of lateral occipital cortex (LO). In addition, amplitude of the P1 visual component is reduced over dorsal stream regions, whereas amplitudes of the ventral stream P1 and N1 components are relatively intact. Visual findings are consistent with impaired visual processing particularly within the magnocellular visual pathway and with impaired dorsal/ventral system interaction. The overall goals of the present study are to further define mechanisms of neurophysiological dysfunction within the auditory and visual systems deficits and to evaluate the degree to which a single underlying deficit (e.g., NMDA dysfunction) could account for the pattern of dysfunction observed. Finally, this project will begin to evaluate the degree to which separate deficits in auditory and visual processing lead to impairments in higher order processes. Relevance to public health: Schizophrenia is a severe mental disorder that affects up to 1% of the population worldwide. Deficits in cognitive function predict poor out come and continued disability. This project will analyze neural basis of cognitive dysfunction.