The Conte Center for Schizophrenia Research

康特精神分裂症研究中心

• 批准号: 8502370
• 负责人: DANIEL C. JAVITT
• 金额: $ 191.78万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-23 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8502370
• 关键词: Affect; Agonist; Animal Model; Auditory; Auditory system; Autopsy; Biometry; Brain; Collaborations; D Aspartate; Development; Disease; Dopamine; Effectiveness; Face; Functional disorder; Generations; Genes; Glutamates; Goals; Hospitals; Human; Image; Impairment; Institutes; Intervention; Investigation; Lasers; Mediating; Mental disorders; Methods; Microscopy; Modeling; Neurocognitive Deficit; New York; Patient Recruitments; Patients; Pharmaceutical Preparations; Physiological; Population; Primates; Process; Research; Research Personnel; Sarcosine; Schizophrenia; Sensory; Sensory Process; Symptoms; Universities; Vision; Visual system structure; aspartate receptor; base; data management; medical schools; neurochemistry; neurogenetics; neurophysiology; neurotransmission; novel; object recognition

This is an application for a new Conte Center for Schizophrenia Research based at the New York University School of Medicine (NYUSoM) and the affiliated Nathan Kline Institute for Psychiatric Research (NKI). Schizophrenia (SZ) is associated with sensory processing deficits that represent a core, but understudied, connponent of the disorder. In the auditory system, patients show deficits in basic processes such as tone matching and auditory mismatch negativity (MMN) generation. In the visual system, patients show deficits in processes such as contrast gain and integration that contribute to higher order impairments in processes such as object recognition and face recognition. Sensory deficits may relate specifically to impairments in Nmethyl- D-aspartate (NMDA) receptor-mediated neurotransmission, and are especially amenable to translational investigation using human and animal models. The Center consists of 6 projects and 3 cores, which build from pre-existing collaborations among Center investigators. Projects 1, 2 and 4 are based at NKI/NYSoM and utilize human (Javitt) and primate (Schroeder) neurophysiological, and human postmortem/laser capture microscopy/gene array (Ginsberg/Smiley) approaches to the study of sensory cortical dysfunction and impaired functional connectivity in SZ. Project 3 (Hlllyard) is based at UCSD and investigates modulatory processes underlying normal visual function. Project 5 (Cornblatt) is based at Zucker Hillside Hospital and investigates sensory processing dysfunction within the SZ prodrome. Finally, Project 6 (Weiser) is based at Sheba Hospital/Tel Aviv University and evaluates effectiveness of sarcosine (N-methylglycine), a naturally occurring NMDA agonist not currently available in the US. Cores are devoted to administration (Javitt), patient recruitment/assessment (Butler) and data management/biostatistics (Robinson/Petkova). Although traditional models of SZ focus on dopamine, more recent models focus on underlying glutamatergic dysfunction, and have received support from neurogenetic, imaging, and treatment studies, as well as challenge studies with putative NMDA antagonists. The overall goal of the Center is to develop new assessment and intervention approaches for schizophrenia based upon glutamatergic models.

这是一个新的精神分裂症研究中心的申请，该中心位于纽约大学医学院（NYUSoM）和附属的内森克莱恩精神病学研究所（NKI）。精神分裂症（SZ）与感觉处理缺陷有关，这是该疾病的一个核心组成部分，但尚未得到充分研究。在听觉系统中，患者表现出音调匹配和听觉失配负性（MMN）产生等基本过程的缺陷。在视觉系统中，患者表现出对比度增益和整合等过程的缺陷，这些缺陷导致了物体识别和面部识别等过程的高阶损伤。感觉缺陷可能与Nmethyl-的损伤有关

项目成果

Gamma band activity and the P3 reflect post-perceptual processes, not visual awareness.

• DOI: 10.1016/j.neuroimage.2014.07.024
• 发表时间: 2014-11-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Pitts MA;Padwal J;Fennelly D;Martínez A;Hillyard SA
• 通讯作者: Hillyard SA

Audio-visual synchrony modulates the ventriloquist illusion and its neural/spatial representation in the auditory cortex

• DOI: 10.1016/j.neuroimage.2014.04.077
• 发表时间: 2014-09-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Bonath, Bjoern;Noesselt, Toemme;Hillyard, Steven A.
• 通讯作者: Hillyard, Steven A.

Spatio-temporal patterns of brain activity distinguish strategies of multiple-object tracking.

大脑活动的时空模式区分了多目标跟踪的策略。

• DOI: 10.1162/jocn_a_00455
• 发表时间: 2014
• 期刊: Journal of cognitive neuroscience
• 影响因子: 3.2
• 作者: Merkel,Christian;Stoppel,ChristianM;Hillyard,StevenA;Heinze,Hans-Jochen;Hopf,Jens-Max;Schoenfeld,MirceaAriel
• 通讯作者: Schoenfeld,MirceaAriel

Intrinsic brain subsystem associated with dietary restraint, disinhibition and hunger: an fMRI study.

与饮食限制、去抑制和饥饿相关的内在大脑子系统：一项功能磁共振成像研究。

• DOI: 10.1007/s11682-015-9491-4
• 发表时间: 2017
• 期刊: Brain imaging and behavior
• 影响因子: 3.2
• 作者: Zhao,Jizheng;Li,Mintong;Zhang,Yi;Song,Huaibo;vonDeneen,KarenM;Shi,Yinggang;Liu,Yijun;He,Dongjian
• 通讯作者: He,Dongjian

Modulating NMDA Receptor Function with D-Amino Acid Oxidase Inhibitors: Understanding Functional Activity in PCP-Treated Mouse Model.

用D-氨基酸氧化酶抑制剂调节NMDA受体功能：了解PCP处理的小鼠模型中的功能活性。

• DOI: 10.1007/s11064-016-1838-8
• 发表时间: 2016-02
• 期刊: Neurochemical research
• 影响因子: 4.4
• 作者: Sershen H;Hashim A;Dunlop DS;Suckow RF;Cooper TB;Javitt DC
• 通讯作者: Javitt DC