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Low-cost High-resolution fundus camera

低成本高分辨率眼底相机

基本信息

批准号：
7863186
负责人：
Peter none Soliz
金额：
$ 3.21万
依托单位：
VISIONQUEST BIOMEDICAL
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-30 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7863186
关键词：
Address Adopted Age related macular degeneration Astigmatism Beds Blood capillaries Caring Clinical Coupled Development Devices Diabetic Retinopathy Diagnosis Diagnostic Disease Doctor of Philosophy Early Diagnosis Engineering Ensure Entropy Excision Eye Eye diseases Fundus Glaucoma Goals Grant Healthcare Systems Human Image Imagery Imaging technology Individual Iowa Laboratories Lasers Masks Measurement Methods Metric Modification Monitor Mydriatics Nerve Fibers Operative Surgical Procedures Ophthalmologist Ophthalmoscopes Optic Disk Optics Performance Phase Price Prospective Studies Radial Research Research Personnel Resolution Retina Retinal Retinal Diseases Scanning Scientist Screening procedure Source Structure System Techniques Technology Testing Time Training Universities abstracting adaptive optics base capillary clinical application commercialization cost design experience human subject improved insight instrument lens optical sensor performance tests prototype research study sensor standard of care tool

项目摘要

SUMMARY ABSTRACT The principal objective is to demonstrate clinically a commercially viable, low-cost, high-resolution fundus camera that: is easy to use, i.e., consistent with the operation of current fundus cameras; has a field of view (FOV) that is typical of current fundus cameras (15 to 30 degrees); has a factor of five or more improvement in resolution as compared to existing clinical instruments; and, will be priced below that of today's clinical devices. In Phase I, a low-cost means for removing low-order aberrations, focus and astigmatism, was demonstrated. It was shown that removal of low-order aberrations would result in significantly better resolution images. In Phase II, the specific aims are to integrate the low-cost low-order aberrations compensator into a scanning laser ophthalmoscope (SLO). This new SLO would produce retinal and optic disc images that have five times better resolution when compared to today's commercial cameras. Researchers have sought to gain greater insight into the mechanisms of the retina and the optic disc at high spatial resolutions that would enable the visualization of structures (4 to 8 micrometers) such as capillaries and nerve fiber bundles. Major sources of retinal image quality degradation are aberrations within the human eye. The presence of these ocular aberrations, many of them random and non deterministic, limits the achievable resolution and the contrast of small image details due to diffraction effects. To overcome these fundamental limitations, researchers have been applying adaptive optics techniques to correct for the aberrations. Today, deformable mirror based adaptive optics devices have been developed to overcome the limitations of standard fundus cameras, but at prices in excess of $500,000. The device proposed by VisionQuest addresses the same goals as the above research grade adaptive optics instruments but does so in a manner which will ultimately be better suited for clinical use because of its similarity to current retinal photographic techniques and its lower cost technology. Our proposed device avoids the high costs, complexity, and limited FOV by adopting unique and notably less expensive wavefront measurement and aberration correction techniques. VisionQuest's goal is to demonstrate an advanced imaging technology that introduces an effective and low cost ($10,000 or less) diagnostic tool to the healthcare system. NARRATIVE Retinal imaging for the purposes of diagnosis of retinal diseases or for monitoring the treatment and/or progression of retinal diseases is standard of care. Greatly improved images of the retina, especially at costs that are lower than current fundus cameras, would have a significant impact on our ability to implement broad-scale screening throughout the U.S. for retinal disease. A low-cost retinal camera would enable the early detection and care of individuals with any of the three major eye diseases, i.e., age-related macular degeneration, diabetic retinopathy, or glaucoma.

摘要文摘