Quality of Maternal Care Moderates the Developmental Consequences of Exposure to

孕产妇护理质量可减轻暴露于环境中的发育后果

• 批准号: 7816825
• 负责人: Elysia Poggi Davis
• 金额: $ 7.65万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7816825
• 关键词: Address; Age-Years; Animal Model; Animals; Award; Behavior; Biological; Biological Markers; Caring; Child; Child Care; Childhood; Code; Cognitive; Continuity of Patient Care; Data; Development; Disease; Endocrine; Environment; Evaluation; Exposure to; Fetus; Funding; Goals; Grant; Health; Hormones; Human; Human body; Hydrocortisone; Infant; Infant Behavior; Infant Development; Laboratories; Literature; Measures; Mother-Child Relations; Mothers; National Institute of Child Health and Human Development; Outcome; Pain; Perinatal Exposure; Play; Postnatal Care; Postpartum Period; Pregnancy; Prospective Studies; Protocols documentation; Psyche structure; Psychological Stress; Psychosocial Stress; Publishing; Questionnaires; Regulation; Reporting; Research; Risk; Role; Salivary; Shapes; Signal Transduction; Stress; Temperament; Time; Toddler; Work; cohort; design; digital video recording; early childhood; improved; indexing; infancy; infant temperament; maternal stress; postnatal; prenatal; prenatal exposure; prenatal stress; programs; prospective; psychologic; psychosocial; public health relevance; response; stressor

DESCRIPTION (provided by applicant): The goal of this proposal is to determine whether postnatal maternal care can moderate the effects of prenatal exposure to maternal stress on infant/toddler development. Accumulating data indicate that prenatal exposure to maternal psychosocial stress and stress hormones has lasting consequences for development. In the animal literature, there is evidence that postnatal maternal care can moderate the impact of these prenatal exposures. While there is a large body of human work documenting the critical role that maternal care plays in shaping a variety of developmental outcomes, little is known about whether postnatal care moderates prenatal stress exposures. The proposed project will address this question using a prospective design and objective laboratory observational measures. We have prospective data collected on mother infant/toddler pairs collected serially from 14 weeks of gestation through two years of age. Maternal psychosocial and endocrine indicators of maternal stress were collected five times during the prenatal period. Infant development was assessed four times from 3 to 24- months. The purpose of this application is to obtain funds to score existing digital video recordings of maternal child interactions to determine whether the quality of maternal care (level and stability) moderates the influence of prenatal stress on the development of (i) fearful temperament, (ii) stress regulation, and (iii) cognitive development during the first two postnatal years. Observations of mother-infant/toddler interactions were collected at 3, 6, 12 and 24-months using a standardized protocol to assess the quality of maternal care including evaluation of maternal sensitivity and responsiveness that was developed for the NICHD Early Child Care Research Network. Thus we have the unique opportunity to determine whether both the quality of maternal care and the continuity over the first two postnatal years moderate the developmental consequences of prenatal stress in human infants as it appears to in animal models.

描述（由申请人提供）：本提案的目的是确定产后孕产妇护理是否可以缓解产前暴露于母体压力对婴儿/幼儿发育的影响。越来越多的数据表明，产前暴露于母亲的心理社会压力和应激激素对发育有持久的影响。在动物文献中，有证据表明，产后产妇护理可以减轻这些产前暴露的影响。虽然有大量的人类工作记录的关键作用，孕产妇保健在塑造各种发展的结果，很少有人知道产后护理是否缓和产前压力暴露。拟议项目将采用前瞻性设计和客观的实验室观测措施来解决这一问题。我们收集了从妊娠14周到2岁的母亲婴儿/幼儿对的前瞻性数据。产妇的心理和内分泌指标的产妇压力收集五次在产前期间。婴儿发育从3个月到24个月进行了四次评估。本申请的目的是获得资金，对现有的母婴互动数字视频记录进行评分，以确定产妇护理质量（水平和稳定性）是否会调节产前压力对以下方面发展的影响：（i）恐惧气质，（ii）压力调节，（iii）出生后前两年的认知发展。在3个月、6个月、12个月和24个月时，使用标准化方案收集母婴/幼儿互动的观察结果，以评估孕产妇护理质量，包括为NICHD早期儿童护理研究网络开发的孕产妇敏感性和反应性评价。因此，我们有独特的机会，以确定是否产妇护理的质量和连续性在出生后的头两年适度的产前压力在人类婴儿的发育后果，因为它似乎在动物模型。