BIOINFORMATICS AND BIOSTATISTICS CORE FACILITY

生物信息学和生物统计学核心设施

• 批准号: 7960378
• 负责人: JAMES HARNER
• 金额: $ 13.34万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960378
• 关键词: Bioinformatics; Biometry; Biostatistics Core; Cancer Biology; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Computers; Core Facility; DNA Microarray Chip; Data; Data Set; Emerging Technologies; Experimental Designs; Faculty; Funding; Genetic; Goals; Grant; Institution; Malignant Neoplasms; Mass Spectrum Analysis; Modeling; Proteomics; Research; Research Personnel; Research Project Grants; Resources; Scientist; Seeds; Signal Transduction; Software Engineering; Source; Specialist; Statistical Data Interpretation; Structure; Techniques; Training; United States National Institutes of Health; Vision; Work; base; computer based statistical methods; forest; markov model; member; network models; novel strategies; programs; statistics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The analysis of datasets requires statistics in order to validate the findings. The department of statistics supports HSC and MBRCC research efforts through collaborations with HSC scientists providing faculty for statistical analysis of data and input to experimental design and interpretation. The emerging technologies of DNA microarray and Proteomics require advanced biostatistical applications, such as Hidden Markov Modeling and Random Forest techniques, respectively. Faculty members in the Department of Statistics have these expertise, as well. Thus, we set up a dedicated facility in the WVU HSC whereby faculty members from Statistics work in the HSC and provide support for our research program. Additionally, the fields of cancer biology, proteomics and genetics, require bioinformatics support. To this end, the MBRCC and Cobre program hired Lan Guo, a computer scienctist and bioinformatics specialist with advanced training in computer software development. Dr. Guo's developed a novel approach to bioinformatics based on the Dempsey-Shaffer model, which is superior to the currently employed Bayesian Networks model. In turn, the Statistics department has hired a bioinformatics specialist who specializes in analysis of mass spectrometry data. It is our long term goal to establish a Bioinformatics and Biostatistics Program at WVU and this core facility and our new faculty hires will seed this endeavor. In this proposal, we discuss the structure of this core facility, priority use and billing mechanisms, support for faculty research projects, research initiatives, as well as our long term vision of establishing an active bioinformatics program at WVU HSC.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 对数据集的分析需要统计数据，以验证调查结果。 统计部门通过与HSC科学家合作支持HSC和MBRCC的研究工作，为数据的统计分析和实验设计和解释提供教师。 新兴的DNA微阵列和蛋白质组学技术需要先进的生物统计应用，如隐马尔可夫模型和随机森林技术，分别。 统计系的教员也有这些专门知识。 因此，我们在西弗吉尼亚大学HSC建立了一个专门的设施，统计学教师在HSC工作，并为我们的研究计划提供支持。 此外，癌症生物学、蛋白质组学和遗传学领域需要生物信息学的支持。 为此，MBRCC和Cobre项目聘请了一位计算机科学家和生物信息学专家，他在计算机软件开发方面受过高级培训。 郭博士开发了一种基于Dempsey-Shaffer模型的生物信息学新方法，该模型上级目前采用的贝叶斯网络模型。 反过来，统计部门聘请了一位专门从事质谱数据分析的生物信息学专家。 这是我们的长期目标，建立一个生物信息学和生物统计学计划在西弗吉尼亚大学和这个核心设施，我们的新教师聘用将种子这一奋进。 在本提案中，我们讨论了这一核心设施的结构，优先使用和计费机制，支持教师的研究项目，研究计划，以及我们在西弗吉尼亚大学HSC建立一个积极的生物信息学计划的长期愿景。