BIOINFORMATICS AND BIOSTATISTICS CORE FACILITY

生物信息学和生物统计学核心设施

• 批准号: 7609890
• 负责人: JAMES HARNER
• 金额: $ 13.61万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609890
• 关键词: Bioinformatics; Biometry; Biostatistics Core; Cancer Biology; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Computers; Core Facility; DNA Microarray Chip; DNA Microarray format; Data; Data Set; Emerging Technologies; Experimental Designs; Faculty; Funding; Genetic; Goals; Grant; Institution; Mass Spectrum Analysis; Modeling; Proteomics; Research; Research Personnel; Research Project Grants; Resources; Scientist; Seeds; Software Engineering; Source; Specialist; Statistical Data Interpretation; Structure; Techniques; Training; United States National Institutes of Health; Vision; Work; base; computer based statistical methods; forest; markov model; member; network models; novel strategies; programs; statistics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The analysis of datasets requires statistics in order to validate the findings. The department of statistics supports HSC and MBRCC research efforts through collaborations with HSC scientists providing faculty for statistical analysis of data and input to experimental design and interpretation. The emerging technologies of DNA microarray and Proteomics require advanced biostatistical applications, such as Hidden Markov Modeling and Random Forest techniques, respectively. Faculty members in the Department of Statistics have these expertise, as well. Thus, we set up a dedicated facility in the WVU HSC whereby faculty members from Statistics work in the HSC and provide support for our research program. Additionally, the fields of cancer biology, proteomics and genetics, require bioinformatics support. To this end, the MBRCC and Cobre program hired Lan Guo, a computer scienctist and bioinformatics specialist with advanced training in computer software development. Dr. Guos developed a novel approach to bioinformatics based on the Dempsey-Shaffer model, which is superior to the currently employed Bayesian Networks model. In turn, the Statistics department has hired a bioinformatics specialist who specializes in analysis of mass spectrometry data. It is our long term goal to establish a Bioinformatics and Biostatistics Program at WVU and this core facility and our new faculty hires will seed this endeavor. In this proposal, we discuss the structure of this core facility, priority use and billing mechanisms, support for faculty research projects, research initiatives, as well as our long term vision of establishing an active bioinformatics program at WVU HSC.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对数据集的分析需要统计数据来验证研究结果。统计系通过与HSC科学家合作，为HSC和MBRCC的研究工作提供支持，为HSC的数据统计分析和实验设计和解释提供意见。DNA微阵列和蛋白质组学的新兴技术需要先进的生物统计学应用，如隐马尔可夫模型和随机森林技术。统计系的教职员工也拥有这些专业知识。因此，我们在西弗吉尼亚大学HSC设立了一个专门的设施，由统计部门的教职员工在HSC工作，并为我们的研究计划提供支持。此外，癌症生物学、蛋白质组学和遗传学领域需要生物信息学支持。为此，MBRCC和Cobre项目聘请了计算机科学学家和生物信息学专家郭兰，他在计算机软件开发方面接受过高级培训。郭博士开发了一种基于Dempsey-Shaffer模型的生物信息学新方法，该方法优于目前使用的贝叶斯网络模型。反过来，统计部门聘请了一名生物信息学专家，专门分析质谱学数据。在西弗吉尼亚大学建立生物信息学和生物统计学课程是我们的长期目标，这一核心设施和我们新招聘的教职员工将为这一努力提供种子。在这份提案中，我们讨论了这一核心设施的结构、优先使用和计费机制、对教师研究项目的支持、研究计划以及我们在西弗吉尼亚大学HSC建立一个积极的生物信息学项目的长期愿景。