P1-SPATIAL REGULATION OF PROTEIN KINASE A SIGNALING DURING GROWTH CONE GUIDANCE

生长锥引导过程中蛋白激酶 A 信号传导的 P1-空间调节

• 批准号: 7959686
• 负责人: Alan K Howe
• 金额: $ 23.34万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959686
• 关键词: Cell membrane; Cells; Chemicals; Complex; Computer Retrieval of Information on Scientific Projects Database; Coupling; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; DCC gene; Embryonic Development; Funding; Grant; Growth Cones; Institution; Mediating; Nervous system structure; Neurons; Neurosciences; Pattern; Process; Proteins; Regulation; Research; Research Personnel; Resources; Signal Transduction; Source; Stretching; Surface; United States National Institutes of Health; Vascular System; Work; cell motility; ezrin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During embryonic development, nerve cells (or neurons) must stretch from their point of origin to reach their proper target in order to form the intricate, interconnected network of the nervous system. Guiding the journey from origin to target is a complex set of chemical signals that steer neurons away from wrong targets and towards the correct ones. Our proposed work will investigate the interaction of DCC (Deleted in Colorectal Cancer, a signal-receiving molecule on the surface of some neurons) and PKA (Protein Kinase A, a signal-transmitting molecule inside cells) and the importance of this interaction for steering nerve cells to their proper target. Our recent observations suggest that this interaction is mediated by Ezrin, a protein known to be important in coupling the cell membrane to the intracellular cytoskeleton during cell movement. Our proposed work will further define the interplay between DCC, Ezrin, and PKA in controlling neuronal pathfinding and in the morphological similar process of patterning of the vascular system.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在胚胎发育期间，神经细胞(或神经元)必须从它们的起始点伸展到合适的目标，才能形成复杂的、相互连接的神经系统网络。引导从起源到目标的旅程是一组复杂的化学信号，这些信号引导神经元远离错误的目标，转向正确的目标。我们的工作将研究DCC(在结直肠癌中缺失，一种位于某些神经元表面的信号接收分子)与PKA(一种细胞内的信号传递分子)的相互作用，以及这种相互作用对引导神经细胞到达合适的靶点的重要性。我们最近的观察表明，这种相互作用是由Ezrin介导的，Ezrin是一种已知在细胞运动过程中将细胞膜与细胞内细胞骨架偶联的重要蛋白质。我们拟议的工作将进一步定义DCC、Ezrin和PKA在控制神经元路径发现和血管系统模式形成的形态相似过程中的相互作用。