IDEAL2

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 美国甲基苯丙胺(冰毒)滥用迅速升级，迫切需要了解怀孕期间使用冰毒对发育中儿童的影响。据我们所知，IDEA(婴儿发育环境和生活方式研究)是NIH关于产前冰毒暴露和儿童结局的唯一前瞻性纵向研究。 这个项目是对最初的理想队列的5-7年后续行动的延续。5-7年的随访期涵盖了一个重要的年龄范围，此时执行功能神经网络经历了快速发展，儿童进入了关键的学校过渡阶段。这项研究的计划是评估相对较窄的执行功能结果，这一结果得到了已发表的临床前和临床文献以及IDEA自己的初步发现的支持。我们计划研究这些执行功能领域如何影响与学校相关的学术技能。 根据儿童的年龄，有五个数据采集点。在孩子5岁、6.5岁和7岁时，每年去诊所一次，检查孩子是否准备好上学；在孩子7岁时，每年去诊所三次，在7岁时进行家访。在每年的随访中，照顾者提供最新的人口统计信息、CPS参与情况和持续的药物使用情况。在不同的探视中，照顾者提供关于他们的精神状态、压力、智力、精神疾病和药物滥用的家族史、家庭和社区暴力的信息，并参与与他们的孩子一起解决问题的任务。在特定的访问中，通过适合年龄的测试和任务来评估儿童的执行功能能力、学习技能和智商。智商作为执行功能的控制变量进行测量。这项研究的新内容是对被动接触冰毒和其他毒品的儿童头发进行毒理学分析，并首次就儿童在7岁时接触暴力的情况进行了采访。 儿童权利委员会请求在以下领域提供援助：为四名工作人员提供办公场所，使用办公设备(如传真机、复印机、扫描仪、计算机)，储存研究记录和材料，使用考察室进行考察访问，使用设施维护录像设备，并与儿童权利委员会工作人员接触，以便在支持研究的专门知识领域提供指导和支持(例如，财务事项指导、标本储存、数据库开发)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The rapidly escalating abuse of methamphetamine (METH) in the United States, places a sense of urgency on understanding the consequences of METH use during pregnancy for the developing child. To our knowledge, IDEAL (Infant Development Environment and Lifestyle Study) is the only prospective longitudinal NIH study of prenatal METH exposure and child outcome. This project is a continuation of IDEAL for the 5-7¿ year follow-up of the original IDEAL cohort. The 5-7¿ year follow-up period covers an important age range when executive function neural networks undergo rapid development and children make the critical transition to school. The study's plan is to evaluate a relatively narrow band of executive function outcomes supported by the published preclinical and clinical literature and IDEAL's own preliminary findings. We plan to study how these executive function domains affect school related academic skills. There are five data collection points based on the age of the child. There is a visit to the clinic at 5 years to examine school readiness and three annual visits to the clinic when the child is 5.5, 6.5, and 7¿ years and a home visit at 7 years. At annual follow up visits, caretakers provide updates of demographic information, CPS involvement, and ongoing drug use. At various visits, caretakers provide information on their psychiatric status, stress, intelligence, family history of psychiatric illness and drug abuse, household and community violence, and participate in a problem solving task with their child. At specific visits, children's executive function abilities, academic skills, and IQ are assessed by age-appropriate tests and tasks. IQ is measured as a control variable for executive function. New to the study is toxicology analysis of the child's hair for passive exposure to METH and other drugs and for the first time the child is interviewed about exposure to violence at 7¿ years of age. CRC assistance is requested in the following areas: providing office space for four staff, use of office equipment (e.g. fax, copier, scanner, computer), storage space for study records and materials, use of exam rooms to conduct study visits, facilities to maintain videotaping equipment, and access to CRC staff to provide guidance and support in areas of expertise that support the study (e.g. guidance with fiscal matters, storage of specimens, development of databases).