NEURODEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项拟议的研究旨在研究胎儿期接触甲基苯丙胺(MA)对发育中的人类神经系统的潜在解剖和代谢变化，以及这些变化与学龄前儿童行为和发育的可测量变化的关系。初步研究表明，产前MA暴露与特定中枢神经系统区域的体积和生化成分的变化有关，并与注意力和言语记忆障碍有关。该建议的具体目的是：(1)确定产前MA暴露对3岁儿童中枢神经系统结构和代谢的影响，以及(2)研究产前MA暴露、CNS结构和代谢与2岁和3岁时评估的注意力和唤醒/自我调节两个认知领域之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the proposed research is to study the potential anatomic and metabolic changes in the developing human nervous system associated with prenatal methamphetamine (MA) exposure, and the relationship of these changes to measurable alterations in child behavior and development in the preschool period. Preliminary studies suggest that prenatal MA exposure is associated with alterations in the volume and biochemical composition of specific CNS regions, and with disordered attention and verbal memory. The specific aims of the proposal are: (1) to identify the effects of prenatal MA exposure on CNS structure and metabolism in three-year-old children, and (2) to examine the relationship between prenatal MA exposure, CNS structure and metabolism, and two cognitive domains, attention and arousal/self-regulation, assessed at 2 and 3 years of age.