IDEAL2

理想2

• 批准号: 7725342
• 负责人: D CHRISTIAN DERAUF
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725342
• 关键词: Affect; Age; Age-Years; Area; Biological Neural Networks; Child; Child Development; Clinic; Clinical; Cohort Studies; Communities; Computer Retrieval of Information on Scientific Projects Database; Computers; Data Collection; Databases; Development; Drug abuse; Drug usage; Environment; Equipment; Exposure to; Family history of; Funding; Grant; Hair; Home visitation; House Call; Household; Infant Development; Institution; Intelligence; Interview; Knowledge; Life Style; Literature; Measures; Methamphetamine; Outcome; Pharmaceutical Preparations; Pregnancy; Problem Solving; Publishing; Range; Readiness; Records; Research; Research Personnel; Resources; Schools; Source; Specimen; Stress; Telefacsimile; Testing; Time; Toxicology; United States; United States National Institutes of Health; Update; Videotape; Violence; Visit; base; executive function; fetal methamphetamine exposure; follow-up; pre-clinical; prospective; skills

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The rapidly escalating abuse of methamphetamine (METH) in the United States, places a sense of urgency on understanding the consequences of METH use during pregnancy for the developing child. To our knowledge, IDEAL (Infant Development Environment and Lifestyle Study) is the only prospective longitudinal NIH study of prenatal METH exposure and child outcome. This project is a continuation of IDEAL for the 5-7¿ year follow-up of the original IDEAL cohort. The 5-7¿ year follow-up period covers an important age range when executive function neural networks undergo rapid development and children make the critical transition to school. The study's plan is to evaluate a relatively narrow band of executive function outcomes supported by the published preclinical and clinical literature and IDEAL's own preliminary findings. We plan to study how these executive function domains affect school related academic skills. There are five data collection points based on the age of the child. There is a visit to the clinic at 5 years to examine school readiness and three annual visits to the clinic when the child is 5.5, 6.5, and 7¿ years and a home visit at 7 years. At annual follow up visits, caretakers provide updates of demographic information, CPS involvement, and ongoing drug use. At various visits, caretakers provide information on their psychiatric status, stress, intelligence, family history of psychiatric illness and drug abuse, household and community violence, and participate in a problem solving task with their child. At specific visits, children's executive function abilities, academic skills, and IQ are assessed by age-appropriate tests and tasks. IQ is measured as a control variable for executive function. New to the study is toxicology analysis of the child's hair for passive exposure to METH and other drugs and for the first time the child is interviewed about exposure to violence at 7¿ years of age. CRC assistance is requested in the following areas: providing office space for four staff, use of office equipment (e.g. fax, copier, scanner, computer), storage space for study records and materials, use of exam rooms to conduct study visits, facilities to maintain videotaping equipment, and access to CRC staff to provide guidance and support in areas of expertise that support the study (e.g. guidance with fiscal matters, storage of specimens, development of databases).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在美国，甲基苯丙胺（METH）滥用的迅速升级，迫切需要了解怀孕期间使用METH对发育中儿童的后果。 据我们所知，IDEAL（婴儿发育环境和生活方式研究）是唯一一项关于产前METH暴露和儿童结局的前瞻性纵向NIH研究。 该项目是IDEAL的延续，对原始IDEAL队列进行5-7年随访。 5-7？一年的随访期涵盖了一个重要的年龄段，此时执行功能神经网络正在快速发展，儿童正在向学校过渡。 这项研究的计划是评估一个相对狭窄的乐队执行功能的结果支持发表的临床前和临床文献和IDEAL自己的初步研究结果。 我们计划研究这些执行功能领域如何影响学校相关的学术技能。 根据儿童的年龄，有五个数据收集点。 5岁时到诊所检查入学准备情况，5岁半、6岁半和7岁时每年到诊所检查三次，7岁时到家中检查一次。 在每年的随访中，看护人员提供人口统计信息，CPS参与和持续药物使用的更新。 在各种探访中，照料者提供有关他们的精神状况、压力、智力、精神病和药物滥用的家族史、家庭和社区暴力的信息，并与他们的孩子一起参与解决问题的任务。 在特定的访问中，儿童的执行功能能力，学术技能和智商是通过适合年龄的测试和任务来评估的。 智商是作为执行功能的控制变量来测量的。 这项研究的新内容是对儿童被动接触甲基苯丙胺和其他药物的头发进行毒理学分析，并首次对儿童7岁时接触暴力的情况进行采访。 要求儿童权利委员会在以下领域提供援助：为4名工作人员提供办公空间，使用办公设备（例如传真机、复印机、扫描仪、计算机）、研究记录和材料的存储空间、使用检查室进行研究访视、维护录像设备的设施以及接触CRC工作人员以在支持研究的专业领域提供指导和支持（例如，财务事项指导、标本储存、数据库开发）。