COBRE: UDE CORE INFRASTRUCTURE: SHARED FACILITIES

COBRE：UDE 核心基础设施：共享设施

• 批准号: 7959536
• 负责人: ABRAHAM M LENHOFF
• 金额: $ 38.02万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959536
• 关键词: Biotechnology; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Delaware; Engineering; Funding; Grant; Institutes; Institution; Membrane Proteins; Nature; Operative Surgical Procedures; Production; Proteins; Research; Research Infrastructure; Research Personnel; Resources; Source; United States National Institutes of Health; X-Ray Crystallography; bioimaging; college; graduate student

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The COBRE supports the operation of 4 core facilties that are quite diverse in their scope and nature. Two are located at the Delaware Biotechnology Institute (DBI), viz. the Protein Production Facility and the Bioimaging Core, and are administered within the larger set of cores operated by DBI, with Drs. Wu and Czymmek as the respective managers. The Protein Production Facility was funded by the original COBRE grant and is supported primarily by the present COBRE, but the Bioimaging Core is a much larger enterprise administered by DBI, of which the COBRE provides a relatively small fraction. The X-ray Crystallography Core is located in the labs of Dr. Brian Bahnson, the only macromolecular crystallographer on campus, and is supported by COBRE in recognition of the numerous researchers seeking structural information via the facilities there. The College of Engineering Biotechnology Core Facility is a fairly inexpensive operation that is managed locally within the College by Drs. Lenhoff and Robinson with the assistance of postdocs and graduate students.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 COBRE 支持 4 个核心设施的运营，这些设施的范围和性质各不相同。 其中两个位于特拉华生物技术研究所 (DBI)，即。蛋白质生产设施和生物成像核心，并在 DBI 运营的更大的核心组内进行管理，博士。吴和奇梅克分别担任经理。 蛋白质生产设施由最初的 COBRE 拨款资助，主要由目前的 COBRE 支持，但生物成像核心是 DBI 管理的一个更大的企业，其中 COBRE 提供相对较小的部分。 X 射线晶体学核心位于校园内唯一的大分子晶体学家 Brian Bahnson 博士的实验室内，并得到 COBRE 的支持，以表彰众多研究人员通过那里的设施寻求结构信息。 工程生物技术学院核心设施的运营成本相当低廉，由学院内部的 Drs 进行本地管理。 Lenhoff 和 Robinson 在博士后和研究生的帮助下完成了这项工作。