COBRE: UDE CORE INFRASTRUCTURE: SHARED FACILITIES

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 COBRE支持4个核心设施的运作，这些设施的范围和性质相当不同。 两个位于特拉华州生物技术研究所（DBI），即蛋白质生产设施和生物成像核心，并在DBI运营的较大核心组内管理，Wu博士和Czymmek博士分别担任经理。 蛋白质生产设施由最初的COBRE拨款资助，主要由目前的COBRE提供支持，但生物成像核心是由DBI管理的一个更大的企业，其中COBRE提供的份额相对较小。 X射线晶体学核心位于Brian Bahnson博士的实验室，他是校园里唯一的大分子晶体学家，并得到COBRE的支持，以表彰许多研究人员通过那里的设施寻求结构信息。 工程生物技术核心设施的学院是一个相当便宜的操作，是由博士Lenhoff和罗宾逊在博士后和研究生的协助下，在学院内本地管理。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The COBRE supports the operation of 4 core facilties that are quite diverse in their scope and nature. Two are located at the Delaware Biotechnology Institute (DBI), viz. the Protein Production Facility and the Bioimaging Core, and are administered within the larger set of cores operated by DBI, with Drs. Wu and Czymmek as the respective managers. The Protein Production Facility was funded by the original COBRE grant and is supported primarily by the present COBRE, but the Bioimaging Core is a much larger enterprise administered by DBI, of which the COBRE provides a relatively small fraction. The X-ray Crystallography Core is located in the labs of Dr. Brian Bahnson, the only macromolecular crystallographer on campus, and is supported by COBRE in recognition of the numerous researchers seeking structural information via the facilities there. The College of Engineering Biotechnology Core Facility is a fairly inexpensive operation that is managed locally within the College by Drs. Lenhoff and Robinson with the assistance of postdocs and graduate students.