INBRE CENTRAL INSTRUMENTATION CORE

INBRE中央仪表核心

• 批准号: 7610183
• 负责人: ABRAHAM M LENHOFF
• 金额: $ 65.16万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610183
• 关键词: 5 year old; Advertising; Aging; Ally; Anatomy; Applications Grants; Archives; Arts; Atomic Force Microscopy; Award; Bioinformatics; Biological Sciences; Biology; Biomedical Research; Biotechnology; Charge; Chemical Engineering; Chemicals; Chemistry; Church; Client; Communities; Computer Retrieval of Information on Scientific Projects Database; Computer software; Computers; Core Facility; DNA Sequence; Data; Data Set; Databases; Delaware; Development; Doctor of Philosophy; Drops; Educational workshop; Effectiveness; Electrocardiogram; Ensure; Equipment; Evaluation; Event; Faculty; Fees; Fellowship; Film; Foxes; Funding; Future; Gases; Gel; Gene Chips; Genomics; Genotype; Grant; Growth; Health; Heart; Hour; Housing; Image; Improve Access; Individual; Institutes; Institution; Instruction; Internet; Investments; Joints; Laboratories; Lead; Life; Liquid substance; Mass Spectrum Analysis; Metabolic; Microscope; Mid-Atlantic Region; Nuclear Magnetic Resonance; Numbers; Occupations; Operative Surgical Procedures; Physiology; Powder dose form; Practice Management; Price; Process; Production; Professional Education; Progress Reports; Proteins; Proteomics; Qualifying; Range; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Running; Sampling; Scanning; Scanning Probe Microscopes; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Series; Services; Simulate; Solid; Source; Specialist; Specimen; Speed; Stream; Structure; Students; System; Techniques; Training; United States National Institutes of Health; Universities; Videoconferences; Videoconferencing; Vocation; Wireless Technology; base; bioimaging; college; computing resources; cost; day; density; design; digital; experience; falls; improved; instrument; instrumentation; member; microsystems; multi-photon; nanoscale; new technology; next generation; programs; research facility; respiratory; size; symposium; tissue culture; tool; university student

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Delaware INBRE Annual Progress Report (APR) 2007 Grant No. 5P20RR016472-2007 Shared Research Instrumentation Core The Delaware INBRE Shared Research Instrumentation Core provides shared, largely centralized instrumentation located at the Delaware Biotechnology Institute and at several departments of the University of Delaware to researchers throughout the statewide Network. Individual, smaller biomedical research and training laboratories are now in place at each of the academic partner institutions. The Research Instrumentation Centers are in place and operated by a cadre of highly qualified staff scientists. Utilization of these facilities continues to grow with researches throughout the Network. Evaluation mechanisms are in place to track the usage and growth of these shared facilities. Regular meetings are scheduled among the Core Center directors to share common operating strategies. Core Center fee waivers, partially funded by the INBRE grant, provide reduced cost or free center access for faculty and student researchers to launch student projects or to establish baseline data sets for grant development. The Delaware INBRE continues to support workshops for faculty, graduate students and other researchers to present available capabilities within the Network. The continuing focus for the Core Centers is on implementing best management practices to ensure efficient operation and on the long-term sustainability of these facilities. The Research Instrumentation Centers in the Delaware INBRE include: Instrumentation Center Core Center Staff 2006 User Base [# of Faculty Groups] Bioimaging Kirk Czymmek, PhD 170 Elizabeth Adams, PhD (11,971 hours total) Deborah Powell, BS (42% increase over 05) Shanon Modla. MS Bioinformatics Douglas ONeal, PhD 14 Mihailo Kaplarevic, MEE (23 projects) Eric Garrison, MS (decrease of 20% due to new charge mechanism) DNA Sequencing & Genotyping Brewster Kingham, MS 75 (10,000 samples processed) (30% increase since 05) Mass Spectrometry John Dykins, MS 6 (9% usage increase over 05) Microarray Emily Huang, BS 7 (Significant drop due to change in center strategy) Nuclear Magnetic Resonance Steve Bai, PhD 11 Heather Egolf-Fox, BS (increase of 10%) Protein Production & Analysis Yu-Sung Wu, PhD, 6 Angel Huang, MS (20 researchers, no change) Accomplishments of the Instrumentation Core in the INBRE Year 3 include: 1) A statewide research infrastructure of Biomedical Core Center facilities with state-of-the-art instrumentation and professional staff is in place. 2) A Core Center Web Portal (www.dbi.udel.edu/coreinstrumentation.html) is available for faculty and students across the INBRE Network to locate research resources. The Core Center Web Portal describes available instrumentation, lists contact information for Core Center directors and staff, and provides information for pricing for services and scheduling for instrument access. 3) A Core Center Fee Waiver program is partially supported by the INBRE to provide free access for new researchers to the Core Centers for developmental projects that lead to the creation of baseline data for future grant proposals. During the current year, 12 faculty projects for a total of $30,600 have been awarded. These projects included faculty members from 3 different institutions. 4) Core Center Directors, including Dr. Katia Sol-Church from the COBRE-supported Biomolecular Core at Nemours, meet on a bi-monthly basis to discuss best practices for common issues such as scheduling, billing, advertising, and joint workshops. Professional education of scientific Core Center staff members continued through attendance at regional and national conferences and at internal workshops. 5) The Bioinformatics Center has installed a software portal to ease access to the considerable computing resources for all members in the INBRE Network. This portal allows users to submit new computing jobs into the computing server queue and improves access to a broad set of life sciences and biomedical software available to users of the Bioinformatics Center. 6) The Core Centers provided several workshops and short courses to reach out to new faculty and students across the network. " The Bioimaging Center hosted the 3rd Regional Zeiss User Meeting on January 16-18, 2007. The three-day event was attended by about 30 core center directors from the Mid-Atlantic region. Zeiss organizes these events to introduce high-end users to new technologies, in this case the next-generation confocal microscope. Based on this workshop and the access to next-generation instrumentation, UD is now considering a major upgrade to the confocal setup in the Bioimaging Center. " DSU held its first ever Internet2 day on October 24, 2006. The workshop was organized and hosted by Dr. Jaiwant Mulik and the INBRE-supported Delaware Scientific and Advanced Computing Center (DeSAC) at DSU. The program was intended to highlight the new capabilities of DSUs access to the Internet2 consortium. About 30 DSU faculty attended the event including representatives from UD, Wilmington College and Delaware Technical Community College. " A Core Center Open House was held at DBI on September 29, 2006. The Open House event included presentations by all Core Center directors and was followed by tours and demonstrations in the labs. Attendance doubled from the previous year to 62 attendees representing all institutions across the Network. Evaluations submitted by the attendees showed a very high effectiveness of the workshop and the Core Center tours, and a high appreciation for the center introductions by the core directors. " The Open House presentations were video-streamed live across the recently installed INBRE-supported videoconference system. An archived copy of the Open House and a growing number of other research presentations is available on the DBI web under www.dbi.udel.edu/events/luncheons.html. 7) Two new Staff Scientists were added to the Core Centers: " Dr. Elizabeth Adams, a newly hired expert in Atomic Force Microscopy in the Bioimaging Center gave a video-streamed presentation on September 28, 2006. Her presentation was the kickoff event of the fall luncheon seminar series and was attended by over 100 people. " Dr. Mihailo Kaplarevic has joined the Bioinformatics Center as a Database Specialist. Dr. Kaplarevic will bring much needed expertise for faculty and students in the Network to design, manage and analyze large scale genomic and proteomic databases. 8) The original investment into Core Center instrumentation has been over $7 Million. Some of the instruments are now between 3 and 5 years old. DBI has invested about $1.5 Million in 2005 and about $1M in 2006 into the replacement and upgrade of the Core center instrumentation. Funds are generated partially through INBRE funding and to a growing amount from other sources: " A fluorescent attachment for an existing microscope was installed in the tissue culture facility at DBI to enable researchers to more easily analyze their specimens. ($10k) " Two AlphaImager Mutlti-Imaging systems were installed in the Common Core facility at DBI to replace two aging instruments. The common facilities are frequently used by INBRE-supported faculty members from across the Network. ($20k) " A confocal microscope located at the UD Lewes campus has been significantly upgraded with INBRE funds and relocated to the Bioimaging Center at DBI to reduce the increasingly long waiting lines at the multi-photon confocal microscope and provide broader access to this instrument for the research community. ($30k) " A Veeco Bioscope Atomic Force Microscope (AFM) was installed in the Bioimaging Center. To support and maximize the value of this new capability, the Bioimaging Center hired Dr. Elizabeth Adams, an experienced scanning probe microscopist who joined DBI in March 2006 after completing her postdoctoral fellowship at Oxford University in the U.K. The AFM was purchased with funds provided by the NSF-EPSCoR program. ($230k) " A Rigaku small angle x-ray scattering (SAXS) camera was installed in the Chemical Engineering Department in August 2006 to support the hire of a new faculty member, Dr. Thomas Epps, III, who joined the faculty in June 2006. The SAXS instrument will be used to investigate crystalline, semi-crystalline, and amorphous materials with nanoscale features in the 1-100 nm range. Dr. Epps will provide access to and expertise for this instrument for other researchers in the Network to analyze powders, films, solids, liquids, and gels with structures on the relevant size-scale. Funds were provide dby the NSF EPSCoR program ($300k). " The Microarray Center was upgraded with a new scanner for the Affymetrix Gene Chip system to allow use of newer high-density gene chips with funds provided through a recently awarded USDA grant. A new Nanodrop spectrophotometer was added to the facility this year, and is heavily used by the community. ($120k) " A new Sun Microsystems bioinformatics database server with 24 Terabyte of disk space is being installed in the Bioinformatics Center with funds provided by a DOE grant. This upgrade will greatly enhance the bioinformatics capacity of the Network. ($180k) 9) Partner institutions used INBRE funds to add the following research instrumentation: " Delaware State University upgraded its the campus-wide IT structure, and builds on recent membership in the Internet 2 consortium. To that end, DSU purchased a CISCO 6509 switch to be the heart of an upgraded high-bandwidth network with wireless capability in the Science Center. The University is providing four CISCO 4503 switches to control four of the planned six sub-networks. This capability will provide high-speed connectivity to departments and research facilities across the DSU campus. " Delaware Technical & Community College (DTCC) purchased equipment to improve instruction in the Allied Health program and in the Sciences. This equipment includes an EKG Cycloergometer. The state-of-the-art cycle ergometer is computer operated and controlled and allows for extremely reliable and reproducible results. The 12 lead EKG module, combined with metabolic gas analysis, allows DTCC students to run a complete cardio-respiratory evaluation of clients, and provides DTCC students with the opportunity to simulate the types of experiences they will have within their vocation and prepares them better for the workforce. In addition, DTCC is planning to purchase and install several pieces of laboratory equipment including a fraction collector for the Biotechnology lab and a digital camera for the microscope in the Anatomy & Physiology lab. Finally, chemical storage cabinets were purchased for the renovated Biology/Chemistry stockroom. " Wesley College purchased instrumentation to expand undergraduate research experiences. This instrumentation will provide analysis techniques previously unavailable as well as training and presentation tools to provide this information to a broader audience within Wesley.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 特拉华州近交年度进度报告（4月）2007年 赠款号5P20RR016472-2007 共享研究仪器核心 特拉华州inbre共享的研究工具核心提供了位于特拉华生物技术学院和特拉华大学的多个系的共享，主要集中的仪器，向整个全州网络的研究人员提供了共享的仪器。 每个学术合作伙伴机构现在都有个人，较小的生物医学研究和培训实验室。 研究仪器中心已经到位，并由一群高素质的员工科学家进行操作。随着整个网络的研究，这些设施的利用不断增长。 正在制定评估机制，以跟踪这些共享设施的使用和增长。定期会议计划在核心中心主管之间共享共同的操作策略。 由Inbre Grant部分资助的核心中心费用豁免为教职员工和学生研究人员提供了降低的成本或免费中心访问，以启动学生项目或为赠款开发建立基线数据集。 特拉华州的近亲继续为教职员工，研究生和其他研究人员的讲习班提供支持，以在网络中提供可用的功能。 核心中心的持续重点是实施最佳管理实践，以确保有效的运营和这些设施的长期可持续性。 特拉华近亲的研究仪器中心包括： 仪器中心核心中心员工2006用户群 [教师小组的＃] 生物成像Kirk Czymmek，博士学位170 伊丽莎白·亚当斯（Elizabeth Adams）博士（总计11,971小时） 黛博拉·鲍威尔（Deborah Powell），学士学位（比05增长42％） Shanon Modla。多发性硬化症 生物信息学Douglas O Neal，博士14 Mihailo Kaplarevic，MEE（23个项目） 埃里克·加里森（Eric Garrison），MS（降低20％ 到新的电荷机制） DNA测序和基因分型Brewster Kingham，MS 75 （处理了10,000个样品） （自05以来增加30％） 质谱法约翰·迪金斯（John Dykins），MS 6 （9％的使用率超过05） 微阵列Emily Huang，BS 7 （由于中心策略的改变而大幅下降） 核磁共振史蒂夫·拜，博士11 Heather Egolf-Fox，BS（增加10％） 蛋白质生产和分析Yu-Sung Wu，博士，6 Angel Huang，MS（20名研究人员，没有变化） 在近亲3年中，仪器核心的成就包括： 1）拥有最先进的仪器和专业人员的生物医学核心中心设施的全州研究基础设施。 2）核心中心网站（www.dbi.udel.edu/coreinstrumentation.html）可用于整个INBRE网络的教职员工，以找到研究资源。 Core Center Web门户网站描述了可用的仪器，列出了核心中心主管和员工的联系信息，并提供了用于服务和安排仪器访问的信息。 3）核心费用豁免计划得到了INBRE的部分支持，为新研究人员提供了开发项目的自由访问，从而为未来的赠款提案创建基线数据。 在本年度，已授予12项总计30,600美元的教职项目。 这些项目包括来自3个不同机构的教职员工。 4）核心中心主任，包括Nemours的毛皮支持的生物分子核心的Katia Sol-Church博士，每两月开会，讨论针对日程安排，计费，广告和联合工作坊等常见问题的最佳实践。 科学核心中心工作人员的专业教育继续参加区域和民族会议以及内部研讨会。 5）生物信息学中心已经安装了一个软件门户，以简化近亲网络中所有成员的大量计算资源的访问。 该门户网站允许用户将新的计算作业提交到计算服务器队列中，并改善对生物信息学中心用户可用的广泛生命科学和生物医学软件的访问。 6）核心中心提供了几个研讨会和短期课程，可以与整个网络的新教师和学生接触。 “生物成像中心于2007年1月16日至187日举行了第三次区域Zeiss用户会议。为期三天的活动是由中大西洋地区的大约30个核心中心主管参加。生物成像中心的共聚焦设置。 “ DSU在2006年10月24日举行了有史以来的第一个Internet2日。该研讨会由Jaiwant Mulik博士和DSU的Inbre供您的inbre养育的特拉华州科学和高级计算中心（DESAC）组织和主持。该计划旨在强调DSU访问Wil Internet2 Atty and the dsuult的新能力。特拉华技术社区学院。 “ 2006年9月29日在DBI举行了一个核心中心开放日。开放日活动包括所有核心中心主管的演讲，随后在实验室进行了参观和示威。上一年的出勤率从上一年翻了一番，达到了62名参与者，代表了整个网络的所有机构。与与会者的评估相关的核心中心和核心中心的高度效果和核心中心的兴趣和核心中心的兴趣，并在核心中心介绍了一位，并且是一个较高的参与者，并且是该集团的高度效果。 “开放式演示文稿是在最近安装的inbre支持的视频会议系统中现场直播的。开放日的归档副本，越来越多的其他研究演示可以在www.dbi.udel.udel.edu/events/events/luncheons.html上使用DBI Web上提供。 7）将两名新的员工科学家添加到核心中心： “生物成像中心的新雇用的原子力显微镜专家伊丽莎白·亚当斯（Elizabeth Adams）博士在2006年9月28日进行了视频流的演讲。她的演讲是秋季午餐研讨会系列的开球活动，并有100多人参加。 “ Mihailo Kaplarevic博士已加入了生物信息学中心，担任数据库专家。Kaplarevic博士将为网络中的教职员工和学生带来急需的专业知识，以设计，管理和分析大型基因组和蛋白质组学数据库。 8）对核心中心仪器的原始投资已超过700万美元。 现在有些乐器在3到5岁之间。 DBI在2005年投资了约150万美元，并在2006年投资了约100万美元，以替换和升级核心中心仪器。 资金是通过Inbre资金部分产生的，并从其他来源获得了越来越多的资金： “在DBI的组织培养设施中安装了现有显微镜的荧光附件，以使研究人员可以更轻松地分析其标本。（$ 10K） “在DBI的Common Core设施中安装了两个Alphaimager mutltimaging系统，以替换两种老化的仪器。共同的设施经常由整个网络的Inbre支持的教职员工经常使用。（$ 20K）（$ 20K） “位于UD Lewes校园的共聚焦显微镜已通过INBRE资金进行了显着升级，并搬到了DBI的生物成像中心，以减少多个Photon共聚焦显微镜的越来越长的等待线，并为该乐器提供了更广泛的访问该乐器的研究社区（$ 30K）。（$ 30K）（$ 30K）。 " A Veeco Bioscope Atomic Force Microscope (AFM) was installed in the Bioimaging Center. To support and maximize the value of this new capability, the Bioimaging Center hired Dr. Elizabeth Adams, an experienced scanning probe microscopist who joined DBI in March 2006 after completing her postdoctoral fellowship at Oxford University in the U.K. The AFM was purchased with funds provided by the NSF-EPSCOR计划（$ 230K） " A Rigaku small angle x-ray scattering (SAXS) camera was installed in the Chemical Engineering Department in August 2006 to support the hire of a new faculty member, Dr. Thomas Epps, III, who joined the faculty in June 2006. The SAXS instrument will be used to investigate crystalline, semi-crystalline, and amorphous materials with nanoscale features in the 1-100 nm range. Dr. Epps will provide access to and该工具的专业知识用于网络中的其他研究人员，可以在相关尺寸尺度上分析粉末，胶片，液体和凝胶，并提供NSF EPSCOR计划（$ 300K）。 “微阵列中心用新的扫描仪升级了Affymetrix基因芯片系统的新扫描仪，以允许使用新的高密度基因芯片，该基因芯片和通过最近授予的USDA Grant提供的资金提供了。 “新的Sun Microsystems生物信息学数据库服务器服务器具有24 TRABYTE的磁盘空间，并在生物信息学中心安装了DOE Grant提供的资金。此升级将极大地增强网络的生物信息性能。（$ 180K）（$ 180K） 9）合作伙伴机构使用inbre资金添加以下研究工具： “特拉华州立大学升级了其校园范围内的IT结构，并建立在互联网2财团的最新成员身份。为此，DSU购买了Cisco 6509的转换，是一个具有升级的高频网络的核心，该网络具有升级的高无线网络，该网络在科学中心提供了无线能力。 DSU校园的部门和研究设施。 " Delaware Technical & Community College (DTCC) purchased equipment to improve instruction in the Allied Health program and in the Sciences. This equipment includes an EKG Cycloergometer. The state-of-the-art cycle ergometer is computer operated and controlled and allows for extremely reliable and reproducible results. The 12 lead EKG module, combined with metabolic gas analysis, allows DTCC students to run a complete cardio-respiratory evaluation of clients, and provides DTCC的学生有机会模拟他们在职业中的经验类型，并为劳动力做好准备。 “卫斯理学院购买了仪器以扩大本科研究经验。该仪器将提供以前无法使用的分析技术以及培训和演示工具，以向卫斯理的更广泛的受众提供此信息。