IMMUNE MODULATION AND RESTORATION IN HIV-1 INFECTION

HIV-1 感染中的免疫调节和恢复

• 批准号: 7959386
• 负责人: LARISA Y POLUEKTOVA
• 金额: $ 6.69万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959386
• 关键词: Animal Model; Chronic Hepatitis B; Chronic Hepatitis C; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Generations; Grant; HIV; HIV Infections; HIV-1; Hepatitis B; Hepatitis B Virus; Hepatitis C virus; Hepatitis Viruses; Hepatocyte; Human; Immune response; Immune system; Infection; Institution; Liver; Modeling; Mus; Nebraska; Patients; Population; Research; Research Personnel; Resources; Rodent; Rodent Model; Source; United States National Institutes of Health; Viral Antigens; immunoregulation; intravenous drug user; medical complication; reconstitution; restoration; tool; vaccine development; virology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 40 million are infected with HIV-1. Worldwide 33% of HIV patients have chronic hepatitis C virus (HCV) infection and 10% of the HIV-infected population also have chronic hepatitis B (HBV). Almost 90% of intravenous drug users have HIV/HCV co-infection. The significance of such a proposal relates to the absence of an adequate animal model of hepatitis B and C, and co-infection of HIV-1,2 and hepatitis viruses, which represent the real situation in humans. The combination of two infections is related to a significant medical complication in the HIV-1-infected population. HCV, HBV and HIV infections are human infections, which cannot be distinguished in rodents. Thus, only by reconstitution of a mouse with a human immune system where the mouse liver has human hepatocytes will create an adequate model to study human immune response to viral antigens, thereby providing an excellent tool for vaccine development. This unique rodent model allows generation of data that previously could be obtained only in virally infected patients, limiting the necessity of further human studies.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 大约有4 000万人感染了艾滋病毒-1。全世界33%的HIV患者患有慢性丙型肝炎病毒（HCV）感染，10%的HIV感染人群还患有慢性B型肝炎（HBV）。几乎90%的静脉吸毒者有艾滋病毒/HCV合并感染。这一建议的重要性涉及缺乏适当的B型和C型肝炎动物模型，以及HIV-1、2和肝炎病毒的共感染，这代表了人类的真实的情况。两种感染的结合与HIV-1感染人群中的一种重大医疗并发症有关。 HCV、HBV和HIV感染是人类感染，在啮齿动物中无法区分。因此，只有通过用人免疫系统重建小鼠，其中小鼠肝脏具有人肝细胞，才能产生足够的模型来研究对病毒抗原的人免疫应答，从而为疫苗开发提供了极好的工具。这种独特的啮齿动物模型允许生成以前只能在病毒感染患者中获得的数据，限制了进一步人体研究的必要性。